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Zolmitriptan

Drug Class: Commonly Known As: Category:
Serotonin Receptor Antagonist, 5-HT3 Adult

Zolmitriptan - What is it for

​Zolmitriptan is a selective serotonin receptor agonist. It works by reducing inflammation and reversing  the widening of blood vessels in the brain, thereby stopping a migraine headache. It is often used to treat a migraine attack after it begins. It will not prevent a migraine.

Zolmitriptan - Side Effects, Precautions, and Contraindications

What side effects can Zolmitriptan cause?

  • Feeling sleepy, dizziness, tiredness, muscle weakness
    • Do not drive or use machinery
    • Do not drink alcohol when taking this medication
  • Pain or tightness in your throat or jaw
    • If pain is intense and does not go away, please seek medical attention
  • Tingling sensation in your fingers and toes
  • Nausea, vomiting
  • Dry mouth

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body


Signs and symptoms of serotonin syndrome such as:

  • Feeling agitated and restless, other mental changes such as hallucination
  • Heavy sweating, shivering
  • Fast heart rate, irregular heartbeat
  • Rigid or twitching muscles
  • Nausea, vomiting or diarrhoea


Signs and symptoms of a heart attack:

  • Discomfort in the middle of your chest that lasts for a few minutes or goes away and comes back
  • Shortness of breath with or without chest discomfort
  • Chest pain or chest discomfort that feels like an uncomfortable heavy pressure, squeezing, fullness or pain

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

 

Before taking Zolmitriptan, what precautions must I follow?

​Inform your healthcare professional if:
• You are allergic to this medication or any of the other ingredients of this medication.
• You have history of heart condition or stroke, uncontrolled blood pressure, liver or kidney diseases.
• You are taking medications under the class of selective serotonin reuptake inhibitors (SSRI) e.g. fluoxetine, serotonin and norepinephrine reuptake inhibitors (SNRI) e.g. venlafaxine, monoamine oxidase inhibitors (MAOI) e.g. isocarboxazid, phenelzine, tranylcypromine.
• You are pregnant, planning to become pregnant, or breastfeeding.
• You are taking any other medications, including supplements, traditional medications and herbal remedies.

What food or medicine must I avoid when I take Zolmitriptan?

​Avoid taking different triptans or triptan combination products (e.g. eletriptan, sumatriptan etc.), or medications containing ergotamine (e.g. Caffox, Cafergot) or dihydroergotamine within 24 hours after taking zolmitriptan.

Zolmitriptan - Dosage and How to Use

How should Zolmitriptan be used?

  • ​Follow your doctor’s instructions as to how many tablets to take when the attack starts. It should work within 1 hour.
  • If your migraine improves but comes back, wait at least 2 hours before taking the next dose. Do not take more than (4 tablets) 10mg per day.
  • However, if you are taking a medication called cimetidine (for indigestion or stomach ulcers), the maximum dose per day is (2 tablets) 5mg.
  • Do not use zolmitriptan too frequently (limit of 10 days use per month), as it may cause medication overuse headache (migraine/headache may worsen).
  • Zomig Rapimelt is designed to dissolve on the tongue rather than be swallowed. Peel open the foil packaging and gently remove a tablet. Do not push the tablet through the foil. Place it on your tongue and allow it to dissolve before you swallow.
  • You may take this medication with or without food.
  • If the tablets did not give you enough help with your migraine, consult your doctor.

What should I do if I miss a dose?

What should I do if I overdose?

Zolmitriptan - Handling

How should I handle Zolmitriptan safely?

Zolmitriptan - Storage

How should I store Zolmitriptan?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#

How should I dispose of Zolmitriptan safely?

​Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.

Zolmitriptan - Additional Information

  • Updated on Sunday, February 28, 2021
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

    ​If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

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