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Sulphasalazine - Side Effects, Precautions, and Contraindications

What side effects can Sulphasalazine cause?

Common side effects of this medication include:

  • Gastrointestinal discomfort
  • Nausea and vomiting
  • Diarrhoea
  • Muscle pain
  • Reduced appetite
  • Insomnia
  • Dizziness
  • Headache
  • Ringing in the ears
  • Itchiness
  • Cough

If symptoms persist or cause significant discomfort, please consult your healthcare professional.

Some Rare but Serious Side Effects:

This medication may affect the blood particularly in the first few months of treatment. Report to your healthcare professional any unexplained bleeding, bruising, sore throat, fever or malaise that occur during treatment. You may be required to have your blood checked regularly while taking this medication.

This medication may affect the liver. Report to your healthcare professional signs of liver problems including persistent dark urine or light coloured stool with abdominal discomfort and nausea and vomiting and/or yellowing of the skin or eyes. Your healthcare professional will require you to have your blood checked at intervals to monitor your liver.

This medication may affect the kidney. Inform your healthcare professional if you are passing less or no urine or if there is blood in the urine.

In rare cases, serious skin reactions may occur with this medication such as Stevens-Johnson syndrome and toxic epidermal necrolysis. If you develop symptoms such as a red, swollen, peeling and/or a blistering rash, please consult your healthcare professional immediately.

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking Sulphasalazine , what precautions must I follow?

Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication. This includes a sulphur allergy or allergy to sulfur antibiotics / sulfonamides.
  • You have glucose-6-phosphate dehydrogenase deficiency (G6PD). If you take this medication, there is a risk you may develop anaemia.
  • You have low white blood cell counts.
  • Inform your doctor if you have a history of liver or kidney disease.
  • You are pregnant, planning to become pregnant, or breastfeeding.
  • You are taking any other medications, including supplements, traditional medications and herbal remedies.
  • Some soft contact lenses may be stained when using this medication.

What food or medicine must I avoid when I take Sulphasalazine ?

​Inform your healthcare professional if you intend to take any medication over the counter.

  • Updated on 1/31/2021 12:00:00 AM
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

​​​​​​​​​​If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

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