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Drug Class: Commonly Known As: Category:
Cyclin-Dependent Kinase Inhibitor Kisqali® Cancer-related

Ribociclib - Side Effects, Precautions, and Contraindications

What side effects can Ribociclib cause?

  • Nausea and vomiting
    • Take small, frequent meals throughout the day.
  • Decreased appetite
  • Diarrhea or constipation
    • To manage diarrhoea:
      • Drink plenty of clear fluids to replace those lost (2 litres everyday).
      • Avoid oily or spicy food and milk or dairy products.
    • To manage constipation:
      • Drink more water or clear fluids (if you do not have a limit on the amount that you can take each day).
      • Add more fibre to your diet by eating more fruits and vegetables.
  • Rash
    • Avoid taking hot showers.
  • Hair loss
    • Use a gentle shampoo to wash your hair.
  • Feeling tired and lack of energy
    • Do not drive or operate machinery when you feel tired.
  • Headache
  • Decreased white blood cells
    • This may put you at higher risk of infections.
    • To reduce your risk of infection:
      • Avoid crowds and people who are sick. Wear a face mask when you are going out.
      • Wash your hands after using the toilet and before handling food.
      • Eat food that is fresh and completely cooked, and avoid raw or half-cooked food.

Please see your healthcare professional immediately if any of the following occur:

  • Side effects listed above are very bad
  • Signs of infection - fever of 38° C and above, chills, cough, sore throat, pain or burning feeling on passing urine
  • Unusual bleeding, bruising, black sticky stools or blood in urine
  • Cough with chest pain or breathing difficulty
  • Dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin
  • Fast or irregular heartbeat, chest discomfort or if you feel faint, light-headed, or dizzy
  • Symptoms of a drug allergy including one or more of the following:
    • Swollen face/eyes/lips/tongue
    • Difficulty in breathing
    • Itchy skin rashes over your whole body

Before taking Ribociclib, what precautions must I follow?

Inform your healthcare professional if:

  • You are allergic to this medication
  • You or your partner becomes pregnant or is planning for pregnancy
    • You should use effective birth control during and for 3 weeks after stopping Ribociclib.
  • You are breastfeeding
    • Do not breastfeed during treatment
  • You have any other medical conditions such as heart disease
  • You are taking or intend to take any other medication, supplements, traditional medications or herbal remedies

What food or medicine must I avoid when I take Ribociclib?

​Avoid taking grapefruit and pomegranate when you are taking this medication as these may interact with your medication and increase the risk of side-effects.

Ribociclib - Additional Information

​You may refer to the following website if you need more information:

  • Tags: Palbociclib
  • Updated on Monday, September 30, 2019
  • Article contributed by PSS National Medication Information Workgroup

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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