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Drug Class: Commonly Known As: Category:
Cardiovascular Agent Ranexa® Adult

Ranolazine - Side Effects, Precautions, and Contraindications

What side effects can Ranolazine cause?

  • Headache, dizziness
    • Try to avoid sudden changes in posture – stand up slowly from sitting or lying position, and sit or lie down if you feel giddy
  • Constipation, vomiting, nausea
  • Abnormal physical weakness or lack of energy

Ranolazine may slow down your heartbeats, or cause new irregular heartbeats. Symptoms of abnormal heart rhythm include one or more of the following:

  • Irregular heartbeat e.g. slowed heartbeat or palpitations (feels like your heart is racing, pounding, skipping a beat)
  • Severe dizziness or fainting spells

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking Ranolazine , what precautions must I follow?

Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication.
  • You are pregnant, planning to become pregnant, or breastfeeding.
  • You are taking any other medications, including supplements, traditional medications and herbal remedies.
  • You have an abnormal heart condition known as acquired QT interval prolongation.
  • You have liver or kidney problems.

What food or medicine must I avoid when I take Ranolazine ?

Avoid taking grapefruit or its juice when you are taking this medication as grapefruit may interact with your medication and increase the risk of side-effects.

Some medications may interact with ranolazine and affect their effectiveness or increase the risk of side-effects. However, these medications may also be important for your treatment. Inform your healthcare professional of the other medications you are currently taking. Examples include:

  • Certain medications used in the treatment of other heart conditions (e.g. verapamil, diltiazem, sotalol, simvastatin)
  • Cyclosporine, a medication for suppression of the immune system
  • Medications for viral infections (e.g. ritonavir)
  • Medications for bacterial infections (e.g. clarithromycin, erythromycin)
  • Medications for fungal infections (e.g. itraconazole, ketoconazole)

Consult your healthcare professional if you are unsure whether your existing medications can be taken together with this medication.

Ranolazine - Additional Information

The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

​If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

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