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Probenecid - Additional Information

When do I seek IMMEDIATE medical attention?

  • As with any other medications, a very small number of patients using probenecid may experience RARE but serious side effects. Do seek medical attention if the following occur:
    •  Wheezing or trouble breathing
    •  Swelling around the eyes or eyelids
    •  Skin rash, severe itching or hives
    •  Unexplained fever or sore throat
    •  Bloody urine or painful urination
    •  Feeling very tired or weak


  • Your doctor may prescribe pain-relieving treatments to reduce inflammation and pain quickly and to prevent gout flare during the initial treatment.
  • Always check with the doctor or pharmacist first before self-treatment with any over-the-counter medicines.
  • DO NOT take any supplements, alternative or herbal medicines without informing your doctor or pharmacist.

What is the TIME to EFFECT?

  • It usually takes months to notice any improvement in symptoms after starting probenecid.

What special DIETARY instructions should I follow?

  • Maintain adequate hydration (2-3 liters of fluid a day, unless otherwise advised by your doctor).


  • Please tell your doctor if you are breast-feeding, pregnant or likely to become pregnant during the course of treatment with the medication.

In SUMMARY… what you need to know about Probenecid?

  • Take probenecid approximately at the same time every day, unless instructed otherwise by your doctor.
  • Always come for your BLOOD TESTS on the scheduled date.
  • Beware of the SIDE EFFECTS and when to get immediate medical attention.
  • Never take medicines, supplements or herbal treatments OVER-THE-COUNTER without checking with your doctor or pharmacist first.
  • If you have further questions about Probenecid, please call ______________________ (office number) to discuss with your doctor / pharmacist / specialty nurse (please circle as appropriate).
  • Updated on 6/12/2015 12:00:00 AM
  • Article contributed by Pharmacy Singapore General Hospital
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth


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