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Disopyramide

Drug Class: Commonly Known As: Category:
Cardiovascular Agent Adult

Disopyramide - What is it for

Disopyramide is used to treat a condition called Hypertrophic Cardiomyopathy (HCM), which is thickening of the heart muscle. This results in obstruction to blood flowing out of the heart, which may cause breathlessness and chest discomfort during exertion.

Disopyramide slows the heart rate and makes the heart contract less forcefully, which helps reduce obstruction of blood flow in the heart in patients with HCM. This may help to improve symptoms such as breathlessness and chest discomfort. It is usually combined with other heart medications such as a beta- blocker (e.g. Bisoprolol, Atenolol) or a calcium channel- blocker (e.g. Diltiazem, Verapamil).

Disopyramide - Side Effects, Precautions, and Contraindications

What side effects can Disopyramide cause?

Common side effects include dry mouth and eyes, blurred vision, constipation and difficulty passing urine. Patients may also experience headache, sensation of fast heartbeat, dizziness and abdominal bloating. If you experience any of these, inform your Cardiologist in-charge who has prescribed this medication for you.

Disopyramide may affect the heart rhythm, namely the QT-interval which is monitored using an electrocardiogram (ECG). To reduce the likelihood of a severely abnormal heart rhythm, patients should avoid other medications which also prolong the QT-interval.

These include:

  • Certain antibiotics & antifungal medications e.g. Erythromycin, Clarithromycin, Azithromycin, Levofloxacin, Moxifloxacin, Ciprofloxacin, Ofloxacin, Fluconazole, Voriconazole, etc.
  • Domperidone (high doses exceeding 30mg per day)
  • Certain mood stabilizers e.g. Citalopram, Escitalopram, Fluoxetine, Quetiapine, etc

Before taking Disopyramide, what precautions must I follow?

What food or medicine must I avoid when I take Disopyramide?

  • Certain antibiotics & antifungal medications e.g. Erythromycin, Clarithromycin, Azithromycin, Levofloxacin, Moxifloxacin, Ciprofloxacin, Ofloxacin, Fluconazole, Voriconazole, etc.
  • Domperidone (high doses exceeding 30mg per day)
  • Certain mood stabilizers e.g. Citalopram, Escitalopram, Fluoxetine, Quetiapine, etc

Disopyramide - Dosage and How to Use

How should Disopyramide be used?

Disopyramide is available as a 100mg capsule. Follow the dosing instructions given by your Cardiologist. Take this medication before food, on an empty stomach.

What should I do if I miss a dose?

What should I do if I overdose?

Disopyramide - Handling

How should I handle Disopyramide safely?

Disopyramide - Storage

How should I store Disopyramide?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#

How should I dispose of Disopyramide safely?

Disopyramide - Additional Information

You are strongly advised to inform the Cardiologist/Doctor or Pharmacist that you are taking Disopyramide, so that they can ensure that your combination of medications is safe for you.

  • Updated on Thursday, June 9, 2016
  • Article contributed by Department of Pharmacy National Heart Centre Singapore

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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