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Marfan's Syndrome - Symptoms

Marfan's Syndrome - How to prevent?

Marfan's Syndrome - Causes and Risk Factors


Marfan's syndrome is caused by a genetic defect of chromosome 15, which is responsible for the production of fibrillin, an essential protein of connective tissue. Individuals with Marfan syndrome have defective fibrillin genes resulting in specific organ abnormalities. The severity of the abnormalities differs among individuals.


Adults with Marfan's syndrome are advised against lifting heavy objects and to avoid any strenuous exercises because of the malformed heart valves, underlying weakness of the major blood vessels, skeleton and eyes.

Regular eye examination is important and enables early treatment to lessen any eye problems.

Pregnant women with Marfan’s syndrome may be at high risk due to increased stress of the aortic wall especially during delivery.

Those with Marfan’s syndrome should be educated on the specific defects associated with this disorder. Regular check-ups with your cardiologist will help to detect any early complications.

Prevention of Infective Endocarditis (IE)

The incident of IE in congenital patient is higher than general population. Therefore it is important for congenital patient to maintain good oral, dental and skin hygiene as primary prevention. Cosmetic tattooing and piercing are discouraged due to the risk of IE. Antibiotic prophylaxis is considered for patient at highest risk for IE before surgery and dental procedures. Please discuss with your congenital team for the latest update on the antibiotic prophylaxis.

Marfan's Syndrome - Preparing for surgery

Marfan's Syndrome - Post-surgery care

Marfan's Syndrome - Other Information

The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth