Assoc Prof Wang Xiaomeng

​Assoc Prof Xiaomeng Wang is an Associate Professor at the Centre for Vision Research, Duke-NUS Medical School. Prior to this appointment, she worked as an Associate Professor at the Lee Kong Chian School of Medicine, Nanyang Technological University Singapore. She holds a BSc. in Biology from Beijing Normal University, China and a PhD in Genetics from Newcastle University, UK. She subsequently underwent post-doctoral training at Manchester University and University College London, UK.

• ​PhD (2006)
• BSc (2000)

• Senior Principal Investigator, Institute of Molecular and Cell Biology, A*STAR (2022 – Present)
• Member, International Society for Eye Research (ISER) (2020 – Present)
• Member, European Association for Vision and Eye Research (EVER) (2013 – Present)
• ​Member, The Association for Research in Vision and Ophthalmology (ARVO) (2008 – Present)

• ​UK Overseas Research Scholarship (2001)
• London Business School Bursary (2008)
• Wellcome Trust Advanced Course Bursary (2009)
• Koh Boon Hwee Scholars Award (2016)

• NRC Central Gap Fund (2026 – 2027)
• STDR Pilot Grant (2022 – 2024, 2025 – 2027)
• NHIC I2D (2022 – 2023)
• STDR Pre-pilot Grant (2022 – 2023)
• NMRC-IRG (2014 – 2018, 2023 – 2027)
• ​NMRC-LCG: Translational Asian Age-related Macular Degeneration Program (2018 – 2023, 2024 – 2029)
• MOE Tier 1 (2018 – 2020)
• NMRC-LCG: DYNAMO: Diabetes Study in Nephropathy and Other Microvascular Complications (2017 – 2022, 2023 – 2028)
• BMRC SPF-A*STAR-P&G Collaboration Grant (2016 – 2018)
• BMRC SPF SERI-IMCB Programme In Retinal Angiogenic Diseases (2015 – 2021)
• MOE Tier 2 (2015 – 2018)
• MRC (2013 – 2018)

1. Chen CJ, Zhou L, Gunaratne J, Chen HT, Barathi VA, Qiu B, Alli-Shaik A, Chia RN, Lim ST, Joo C, Cheung N, Chan CM, Koh SK, Tan A, Verma RK, Fan H, Song W, Virshup D, Wong TY, Cheung GCM, Hong W, Wang X. FRZB-induced Anti-angiogenic Effect via Caveolin-1-mediated TGFβ Signalling. Nature Communications. 17, 4947 (2026). doi: 10.1038/s41467-026-71326-x.

2. Ang KH, Thura M, Gupta A, Tan QSW, Kuan KY, Li J, Chia PL, Qiu B, Hong JM, Guo K, Wang X, Su X, Zeng Q. Antibody Therapy Against PRL3 as a Treatment for Angiogenic Eye Diseases. Nature Communications. 16, 4791 (2025).

3. Lim ST, Zhao X, Liu S, Zhang W, Tan Y, Mullappilly N, Swain SM, Leong ML, Rajarethinam R, Wan KF, C Ruedl, Liddle RA, Li L, Wang X. LRG1 Inhibition Promotes Acute Pancreatitis Recovery by Inducing Cholecystokinin Type 1 Receptor Expression via Akt. Theranostics. 2025 Mar 18;15(10):4247–4269. doi: 10.7150/thno.110116.

4. Fan Q #, Li H #, Wang X # Tham YC, Teo KYC, Yasuda M, Lim WK, Kwan YP, Teo JX, Chen CJ, Chen LJ, Ahn J, Davila S, Miyake M, Tan P, Park KH, Pang CP, Khor CC, Wong TY, Yanagi Y, Cheung GCM, Cheng C. Contribution of Common and Rare Variants to Asian Neovascular Age-related Macular Degeneration Subtypes. Nat Commun. 2023 Sep 11;14(1):5574. doi: 10.1038/s41467-023-41256-z.

5. Do TC†, Lau JW†, Sun C†, Liu S†, Kha KT, Lim ST, Oon Y, Kwan YP, Ma JJ, Mu Y, Liu X, Carney TJ, Wang X* & Xing B*. Hypoxia Deactivates Epigenetic Feedbacks via Enzyme-derived Clicking Proteolysis Targeting Chimeras. Science Advances 14 Dec 2022. Vol 8, Issue 50. DOI: 10.1126/sciadv.abq2216.

6. Alli-Shaik A†, Qiu B†, Lai SL, Cheung N, Tan G, Neo SP, Tan A, Cheung CMG, Hong W, Wong TY, Wang X*, Gunaratne J*. System-wide Vitreous Proteome Dissection Reveals Impaired Sheddase Activity in Diabetic Retinopathy. Theranostics. 2022 Sep 11;12(15):6682-6704. doi: 10.7150/thno.72947.

7. Pang KT, Ghim M, Liu C, Tay HM, Fhu CW, Chia RN, Qiu B, Sarathchandra P, Chester A, Yacoub M, Wilkinson F, Weston R, Warboys C, Hou HH, P Weinberg P, Wang X. Leucine-rich α-2-glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-mediated Shedding of TNF-α Receptor. Front. Cell Dev. Biol., 05 July 2021. doi.org/10.3389/fcell.2021.706143.

8. Kwan YP, Teo MHY, Lim JCW, Tan MS, Rosellinny G, Wahli W, Wang X. LRG1 Promotes Metastatic Dissemination of Melanoma through Regulating EGFR/STAT3 Signalling. Cancers 2021, 13(13), 3279; https://doi.org/10.3390/cancers13133279.

9. Qiu B, Tan A, Tan YZ, Chen QY, Luesch H, Wang X. Largazole Inhibits Ocular Angiogenesis by Modulating the Expression of VEGFR2 and P21. Mar Drugs. 2021 Aug 22;19(8):471. doi: 10.3390/md19080471.

10. Murray H, Qiu B, Ho SY, Wang X. Complement Factor B Mediates Ocular Angiogenesis Through Regulating the VEGF Signalling Pathway. Int J Mol Sci. 2021 Sep 3;22(17):9580. doi: 10.3390/ijms22179580.

11. Liu C, Teo M, Pek SLT, Wu X, Leong ML, Tay HM, Hou HW, Ruedl C, Moss SE, Greenwood J, Tavintharan S, Hong W, Wang X. A Multifunctional Role of Leucine-rich α-2-glycoprotein 1 in Cutaneous Wound Healing Under Normal and Diabetic Conditions. Diabertes.2020 Nov; 69(11): 2467-2480.

12. Lio D, Chia R, Kwek M, Wiraja C, Chang H, Khadir SMA, Wang X*, Becker DL*, Xu C*. Temporal Pressure Enhanced Topical Drug Delivery Through Micropore Formation. Science Advances. 2020 May 29;6(22):eaaz6919. doi: 10.1126/sciadv.aaz6919.

13. Liu C, Lim ST, Teo M, Tan M, Kulkarni MD, Qiu B, Li A, Lal S, dos Remedios CG, Tan NS, Wahli W, Ferenczi MA, Song W, Hong W, Wang X. Collaborative Regulation of LRG1 by TGFβ1 and PPARβ/δ Modulates Chronic Pressure-overload-induced Cardiac Fibrosis. Circulation: Heart Failure. 2019 Dec;12(12):e005962. doi: 10.1161/CIRCHEARTFAILURE.119.005962.

14. Qiu B, Tan A, Barathi AV, Li Y, Liu C, Murray H, Cheng W, Busoy JM, Chen QY, Sistla S, Hunziker W, Cheung CMG, Wong TY, Hong W, Luesch H, Wang X. Apratoxin S4 Inspired by A Marine Natural Product, a New Treatment Option for Ocular Angiogenic Diseases. IOVS. 2019;60:3254–3263.

15. Njah K, Chakraborty S, Qiu B, Arumugam S, Raju A, Pobatti A, Lakshmanan M, Tergaonkar V, Thibault G, Wang X*, Hong W*. A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 During Tumor Angiogenesis. Cell Report. 2019 July 23; 28 (4): 949-965.

16. Than A, Liu C, Cheng H, Duong PK, Xu C*, Wang X*, Chen P*. Self-implantable Double-layered Micro-drug-reservoirs for Efficient and Controlled Ocular Drug Delivery. Nature Communications. (2018) 9:4433 | DOI: 10.1038/s41467-018-0698.

17. Lio D, Liu C, Wiraja C, Qiu B, Fhu CW, Wang X*, Xu C*. Molecular Beacon-gold Nanosensors for Leucine-rich Alpha-2-glycoprotein-1 (LRG1) Detection in Pathological Angiogenesis. Nature Communications. (2018) 9:4433 | DOI: 10.1038/s41467-018-0698.

18. Song WH, Fhu CW, Ang KW, Liu CH, Nurul ABJ, Lio CS, Abraham S, Moss SE, Greenwood J, Hong WJ, Wang X. The Foetal Mouse Metatarsal Bone Explant as a Model of Angiogenesis. Nature Protocols. 2015 10,1459–1473.

19. Wang X, Abraham S, McKenzie JAG, Jeffs N, Swire M, Lange CAK, Luhmann U, Bainbridge J, Zhai Z, Arthur H, Moss SE, Greenwood J. LRG1 Promotes Angiogenesis by Modulating Endothelial TGFβ Signalling. Nature. 2013 July 18; 499 (7458):306-311.

20. Wang X, Harris RE, Bayston, LJ, Ashe HL. Type IV Collagens Regulate BMP Signalling in Drosophila. Nature. 2008. 455: 72-77.