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Dr Ti Seng Ei

Dr Ti Seng Ei

MBBS, M Med(Ophth), FRCS(Ed)

Senior Consultant

Singapore National Eye Centre

Specialty: Corneal & External Eye Disease, Refractive Surgery, Cataract & Comprehensive Ophthalmology

Sub-specialties: Corneal & External Eye Disease, Refractive Surgery, Cataract & Comprehensive Ophthalmology

Clinical Appointments

  • Senior Consultant SingHealth Duke-NUS Transplant Centre
  • Senior Consultant Corneal & External Eye Disease Department Singapore National Eye CentreSingapore National Eye Centre
  • Senior Consultant Refractive Surgery Department Singapore National Eye CentreSingapore National Eye Centre
  • Senior Consultant Cataract & Comprehensive Ophthalmology Department Singapore National Eye CentreSingapore National Eye Centre

Academic Appointments

  • Clinical Asst Professor SingHealth Duke-NUS Ophthalmology & Visual Sciences Academic Clinical Programme


Dr Ti Seng Ei trained as a Cornea surgeon at Singapore National Eye Centre (SNEC), and completed further training and research on ocular surface disease and amniotic membrane transplantation at Bascom Palmer Eye Institute, Miami, USA.  In 2015, she completed an observership at University of Antwerp, Belgium (Prof. M. Tassignon), for improved understanding on intraocular lens implant centration, technique of lens exchange, quality of vision measurements and cornea surgery. 
Dr Ti’s current clinical interests revolves around complex cataract techniques, cornea transplantation and ocular surface disease.   Her international publications include work on femtosecond laser cataract surgery, surgical techniques, cornea transplantation outcomes and ocular surface disease.
Dr Ti has been actively involved in teaching, at both local, regional and international training courses. Since 2012, as one of the pioneer users of femtosecond laser for cataract surgery (FLACS) in SNEC, she has been part of the SNEC teaching faculty for FLACS for other SNEC doctors.  On the regional front, she is an invited speaker at the Asia-Pacific Academy of Ophthalmology (APAO) meetings and trained attendee doctors from Southeast Asia during the SNEC Intermediate and Advanced Cataract Teaching Courses. For international meetings, she has been a regular cataract course instructor at the annual meeting of American Society Cataract Refractive Surgeons (ASCRS) and also taught at several instruction courses at the European Cataract and Refractive Surgeons (ESCRS) meetings.


  • FRCS(Ed) (1997)
  • M Med(Ophth) (1997)
  • MBBS

Professional Appointments and Committee Memberships

  • Member, Fellowship Committee, Singapore National Eye Centre (2016 - present)
  • Clinician Advisory Committee, Medical Assistance Fund (MAF) plus (2011 - present)


  •  Appreciation Award, Asia-Pacific Academy of Ophthalmology (APAO) (2018)

Research Interests


  1. Chan NS, Ti SE, Chee SP. Decision-making and management of the uveitic cataract. Indian J Ophthalmol. 2017 Dec;65(12):1329-1339. doi: 10.4103/ijo.IJO_740_17. Review

  2. Ti SE, Chee SP. Endoillumination-assisted epithelial down growth management with 5-FU under air tamponade. JCRS Online Case Reports Vol 5, Issue 3, July 2017, pages 41-43

  3. Ti SE, Chee SP. Book Chapter: Capsular Tension Segment Technique for IOL Fixation and Centration. (In preparation - Book: Advanced IOL Fixation Techniques, Publisher SLACK)

  4. Ti SE, Chee SP: Current Concepts in Managing the Posterior Polar Cataract. DOS Times, May-June 2017

  5. Chee SP, Yang YN, Ti SE. Clinical Outcomes in the first 2 years of femtosecond laser-assisted cataract surgery. Am J Ophthal 2015 Apr;159(4):714-719 

  6. Ti SE, Yang YN, Lang S, Chee SP. A 5-year Audit of Cataract Surgery Outcomes after Posterior Capsule Rupture and Risk factors affecting Visual Acuity. Am J Ophthal. 2014 Jan; 157(1):180-185.Epub 2013 Oct31

  7. Chee SP, Jap A, Ling EC, Ti SE. Cytomegalovirus-positive corneal stromal edema with keratic precipitates after penetrating keratoplasty: a case-control study. Cornea. 2013 Aug;32(8):1094-8

  8. Ti SE, Chee SP, Tan DT, Yang YN, Shuang SL. Descemet Membrane detachment after Phacoemulsification surgery: Risk factors and Success of Air Bubble Tamponade. Cornea. 2013 Apr;32(4):454-9 

  9. Ang M, Ti SE, Loh R, Farzavandi S, Zhang R, Tan D, Chan C. Steroid-induced ocular hypertension in Asian children with severe vernal keratoconjunctivitis. Clin Ophthalmol. 2012;6:1253-8.Epub 2012 Aug 3

  10. Li J, Riau AK, Setiawan M, Mehta JS, Ti SE, Tong L, Tan DT, Beuerman RW. S100A expression in normal corneal-limbal epithelial cells and ocular surface squamous cell carcinoma tissue. Mol.Vis. 2011;17:2263-71.Epub 2011, Aug 20

  11. Chee SP, Ti SE, Lim L, Chan AS, Jap A. Anterior segment optical coherence tomography evaluation of the integrity of incisions: a comparison between 2.2-mm and 2.65-mm main incisions. Am J Ophthalmol. 2010 May;149 (5):768-76.e1. Epub 2010 Feb 26

  12. Loh RS, Chan CM, Ti SE, Lim L, Chan KS, Tan DT. Emerging prevalence of microsporidial keratitis in Singapore :epidemiology, clinical features, and management. Ophthalmology. 2009 Dec;116(12):2348-53. Epub 2009 Oct 7 

  13. Parthasarathy A. Theng J, Ti SE, Tan DT. Infectious keratitis after Laser Epithelial Keratomileusis. J Refract Surg. 2007 Oct;23(8):832-Ti SE, Scott JA, Janardhanan P, Tan DT

  14. Ti SE, Scott JA, Janardhanan P, Tan DT. Therapeutic Keratoplasty for Advanced Suppurative Keratitis. Am J Ophthalmol. 2007 Feb 27; [Epub ahead of print]

  15. Ti SE, Chee SP. Cataract surgery in patients with Fuchs'. Ophthalmology. 2006 Oct;113(10):1883-4 

  16. Ti SE, Grueterich M, Espana EM, Touhami A, Anderson DF, Tseng SC. Correlation of long term phenotypic and clinical outcomes following limbal epithelial transplantation cultivated on amniotic membrane in rabbits. Br J Ophthalmol. 2004 Mar;88(3):422-7

  17. Espana EM, Ti SE, Grueterich M, Touhami A, Tseng SC. Corneal stromal changes following reconstruction by ex vivo expanded limbal epithelial cells in rabbits with total limbal stem cell deficiency. Br J Ophthalmol. 2003 Dec;87(12):1509-14 

  18. Theng JT, Ti SE, Zhou L, Lam KW, Chee SP, Tan D. Pharmacokinetic and toxicity study of an intraocular cyclosporine DDS in the anterior segment of rabbit eyes. Invest Ophthalmol Vis Sci. 2003 Nov;44(11):4895-9

  19. Meallet MA, Espana EM, Grueterich M, Ti SE, Goto E, Tseng SC. Amniotic membrane transplantation with conjunctival limbal autograft for total limbal stem cell deficiency. Ophthalmology. 2003 Aug;110(8):1585-92 

  20. Ti SE, Tan DT. Tectonic corneal lamellar grafting for severe scleral melting after pterygium surgery. Ophthalmology. 2003 Jun;110(6):1126-36

Research Trials