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Dr Htoon Hla Myint

Dr Htoon Hla Myint

BDS, PhD

Academic Appointments

  • Assistant Professor SingHealth Duke-NUS Ophthalmology ＆ Visual Sciences Academic Clinical Programme

Profile

​Dr Hla Myint Htoon, is a clinical outcomes research scientist. His work with SERI entails statistical and health economic evaluation research work for clinical outcomes.

Education

  • PhD (2007)
  • BDS (1975)

Professional Appointments and Committee Memberships

  • Member (statistical advisor), Institutional Animal Care and Use Committee, SingHealth (2016 – present)
  • Editorial Board member (statistical advisor), Proceedings Journal Editorial Board (Singapore General Hospital (2013 – present)
  • Statistical Advisor, Education Research Committee, Singapore National Eye Centre (2016 – present)

Awards

Research Interests

  • APP development ( PI, working on  development of Glaucoma Progression Application Tool using a modelling approach)
  • Discrete Event Simulation modelling ( PI, modelling the lifetime management of Primary Angle Closure Glaucoma in Singapore)
  • Utility Index development(  research member of Glaucoma Utility Index for Singapore using discrete choice experiments methodology)
  • Clinical trials: design, sample size, statistical analyses
  • Clinical outcomes research for retrospective and prospective ophthalmology therapeutics (medications, surgical treatments, etc.)
  • AI related Ophthalmology applications
  • Other clinical outcomes research (diagnostics, meta-analysis, cochrane reviews, etc.. )

Publications

  1. Randomized Clinical Trial Comparing Femtosecond LASIK and Small-Incision Lenticule Extraction. Ang M, Farook M, Htoon HM, Mehta JS. Ophthalmology. 2020;127(6):724-730.

  2. Part-time use of 1% atropine eye drops for prevention of myopia progression in children. Foo LL, Htoon H, Farooqui SZ, Chia A . Int Ophthalmol. 2020 Apr 7. [Epub ahead of print]

  3. Effect of Pharmacological Pupil Dilatation on Angle Configuration in Untreated Primary Angle Closure Suspects: A Swept Source Anterior Segment Optical CoherenceTomography Study. Narayanaswamy A, Baskaran M, Tun TA, Htoon HM, Aung T.  J Glaucoma. 2020 Mar 27. [Epub ahead of print]

  4. Visual field progression 8 years after trabeculectomy in Asian eyes: results from The Singapore 5-Fluorouracil Study. Ang BCH, Seen S, Kumaran A, De Leon JMS, Seah SKL, Foster PJ, Gazzard G, Htoon HM, Khaw PT, Aung T, Husain R.  Br J Ophthalmol. 2020 Mar 5. pii: bjophthalmol-2019-314121. doi: 10.1136/bjophthalmol-2019-314121. [Epub ahead of print] PubMed PMID: 32139502.

  5. Hybrid Descemet Membrane Endothelial Keratoplasty (H-DMEK): results of a donor insertion pull-through technique using donor stroma as carrier. Woo JH, Htoon HM, Tan D.Br J Ophthalmol. 2020 Jan 16. pii: bjophthalmol-2019-314932. doi:10.1136/bjophthalmol-2019-314932. [Epub ahead of print] PubMed PMID: 31949091

  6. MRI of posterior eye shape and its associations with myopia and ethnicity. Lim LS, Matsumura S, Htoon HM, Tian J, Lim SB, Sensaki S, Chen C, Hilal S,Wong TY, Cheng CY, Kuo A, Saw SM. Br J Ophthalmol. 2019 Dec 2. pii:bjophthalmol-2019-315020. doi: 10.1136/bjophthalmol-2019-315020. [Epub ahead of print] PubMed PMID: 31791940.

  7. Investigating the neuroprotective effect of Copolymer-1 in acute primary angle closure - Interim report of a randomized placebo-controlled double-masked clinical trial. Fan KR, Baskaran M, Nongpiur ME, Htoon HM, de Leon JMS, Perera SA, Belkin M, Aung T. Acta Ophthalmol. 2019 Sep;97(6):e827-e832.

  8. Protective Action of Linear Polyethylenimine against Staphylococcus aureus Colonization and Exaggerated Inflammation in Vitro and in Vivo. Mayandi V, Sridhar S, Fazil MHUT, Goh ETL, Htoon HM, Orive G, Choong YK,Saravanan R, Beuerman RW, Barkham TMS, Yang L, Baskaran M, Jhanji V, Loh XJ,Verma NK, Lakshminarayanan R.  ACS Infect Dis. 2019 Aug 9;5(8):1411-1422. doi:10.1021/acsinfecdis.9b00102. Epub 2019 Jun 5. PubMed PMID: 31099239.

  9. Characterization of Human Transition Zone Reveals a Putative Progenitor-Enriched Niche of Corneal Endothelium. Yam GH, Seah X, Yusoff NZBM, Setiawan M, Wahlig S, Htoon HM, Peh GSL, Kocaba V, Mehta JS.  Cells. 2019 Oct 12;8(10). pii: E1244. doi: 10.3390/cells8101244. PubMed PMID: 31614883; PubMed Central PMCID:PMC6829622.

  10. Eighteen-year  prospective audit of LASIK outcomes for myopia in 53 731 eyes. Chua D, Htoon HM, Lim L, Chan CM, Mehta JS, Tan DTH, Rosman M.  Br J Ophthalmol.2019 Sep;103(9):1228-1234. doi:1136/bjophthalmol-2018-312587. Epub 2018 Oct24. PubMed PMID: 30355717

  11. Argon Laser Peripheral Iridoplasty for Primary Angle-Closure Glaucoma: A Randomized Controlled Trial. Narayanaswamy A, Baskaran M, Perera SA, Nongpiur ME, Htoon HM, Tun TA, WongTT, Goh D, Su DH, Chew PT, Ho CL, Aung T. Ophthalmology. 2016 Mar; 123(3):514-21

  12. Sustained drug release in nanomedicine: a long-acting nanocarrier-based formulation for glaucoma. Natarajan JV, Darwitan A, Barathi VA, Ang M, Htoon HM, Boey F, Tam KC, Wong TT, Venkatraman SS. ACS Nano. 2014 Aug; 4(4):303-9

  13. The Singapore 5-Fluorouracil trial: intraocular pressure outcomes at 8 years. Wong MH, Husain R, Ang BC, Gazzard G, Foster PJ, Htoon HM, Wong TT, Oen FT, Khaw PT, Seah SK, Aung T. Ophthalmology 2013 Jun;120(6):1127-34

  14. Indications, outcomes, and risk factors for failure in tectonic keratoplasty. Ang M, Mehta JS, Sng CC, Htoon HM, Tan DT. Ophthalmology. 2012 Jul; 119(7):1311-9. Epub 2012 Apr 27. PubMed PMID: 22541633

  15. Diagnosis of tuberculous uveitis: clinical application of an interferon-gamma release assay.Ang M, Htoon HM, Chee SP. Ophthalmology. 2009 Jul; 116(7):1391

  16. Outcomes of therapeutic deep lamellar keratoplasty and penetrating keratoplasty for advanced infectious keratitis: a comparative study. Anshu A, Parthasarathy A, Mehta JS, Htoon HM, Tan DT. Ophthalmology. 2009 Apr; 116(4):615-2315

  17. The Singapore 5-Fluorouracil trabeculectomy study: effects on intraocular pressure control and disease progression at 3 years. Wong TT, Khaw PT, Aung T, Foster PJ, Htoon HM, Oen FT, Gazzard G, Husain R, Devereux JG, Minassian D, Tan SB, Chew PT, Seah SK.  Ophthalmology. 2009 Feb;116(2):175-84 Ophthalmology. 2009 Jul; 116(7): 1391

  18. Comparison of Outcomes of Lamellar Keratoplasty and Penetrating Keratoplasty in Keratoconus. Han DC, Mehta JS, Por YM, Htoon HM, Tan DT. Am J Ophthalmol. 2009 Nov; 148(5):744-751. Ophthalmology. 2009 Jul; 116(7): 1391

  19. Penetrating keratoplasty in Asian eyes: the Singapore Corneal Transplant Study.Tan DT,    Janardhanan P, Zhou H, Chan YH, Htoon HM, Ang LP, Lim LS. Ophthalmology. 2008 Jun; 115(6):975-982. 1391

  20. Assessment criteria for compliance with oral hygiene: application of ROC analysis. Htoon HM, Peng   LL, Huak CY. Oral Health Prev Dent. 2007; 5(2):83-8. 13

Research Trials

  • ​Development of Glaucoma Progression Application Tool using a modelling approach (2017 – 2020)
  • Discrete Event Simulation of a Primary Angle Closure Glaucoma Model in Singapore (2015 – 2021)
  • Development of a novel utility measure using discrete choice experiments to assess the impact of glaucoma treatments from the patient’s perspective (2015 – 2018)
  • Development of Glaucoma Utility Index (GUI-S) in Singapore (2009 – 2013)

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