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Prof Aung Tin

Prof Aung Tin from Singapore National Eye Centre

Prof Aung Tin

MBBS, M Med(Ophth), FRCS(Ed), FRCOphth, FAMS, PhD (Lond)

Senior Consultant

Singapore National Eye Centre

Specialty: Glaucoma

Sub-specialties: Glaucoma

Conditions Treated by this Doctor:
Glaucoma.

Clinical Appointments

  • Deputy Medical Director (Research) Singapore National Eye CentreSingapore National Eye Centre
  • Senior Consultant Glaucoma Department Singapore National Eye CentreSingapore National Eye Centre

Academic Appointments

  • Academic Vice-Chair (Research) SingHealth Duke-NUS Ophthalmology & Visual Sciences Academic Clinical Programme
  • Professor SingHealth Duke-NUS Ophthalmology & Visual Sciences Academic Clinical Programme
  • Professor, SingHealth Duke-NUS Kwan Im Thong Hood Cho Temple Professorship in Ophthalmology

Profile

Professor Aung Tin is a clinician scientist in ophthalmology and currently Executive Director of the Singapore Eye Research Institute (SERI); Senior Consultant, Glaucoma Department and Deputy Medical Director (Research) of the Singapore National Eye Centre (SNEC). He is also a full tenured Professor with the Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, and in 2018, he was conferred the Kwan Im Thong Hood Cho Temple Professorship of Ophthalmology, Duke-NUS Medical School, Singapore.

Professor Aung’s research has secured more than S$20 million in competitive research grant funding. He is a NMRC STAR Investigator since 2015, previously CSA (Junior) from 2007-2010 and CSA (Senior) from 2008-2013. He was awarded the Nakajima Award (2007) and De Campo Award (2013) by the Asia Pacific Academy of Ophthalmology, the Alcon Research Institute Award (2013), the Singapore Translational Research (STaR) Investigator Award (2014), the Robert Ritch Award for Excellence and Innovation in Ophthalmology by the Glaucoma Foundation (2017), as well as numerous other awards/medals.

Professor Aung Tin currently has more than 600 publications including 15 major papers in Nature Genetics (6 as First or last author) as well as papers in JAMA and Lancet. He has delivered more than 100 Invited Lectures at many international meetings. He is on the Editorial Board of 7 journals (including Ophthalmology, Progress in Retinal and Eye Research, Journal Of Glaucoma, Eye and Graefe’s Archive for Clinical Exp Ophthalmology; and a regular reviewer for more than 20 journals.

Professor Aung was President of the World Glaucoma Association from 2016-2017, and also serves as Board Member of the WGA and Asia Pacific Glaucoma Society. He was President of the College of Ophthalmologists of Singapore from 2012-2014 and President of the Singapore Society of Ophthalmology from 2009-2011.
Professor Aung is actively involved in medical education of undergraduates and post graduates. He supervises and mentors Research Fellows, Trainees and Students, especially in the areas of glaucoma and translational research.

Education

  • PhD (Lond) (2004)
  • FAMS (2003)
  • FRCOphth (1997)
  • FRCS(Ed) (1997)
  • M Med(Ophth) (1997)
  • MBBS (1990)

Professional Appointments and Committee Memberships

  • Professor, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore (2006 - Present)
  • Director, Centre for Vision Research (CVR), Duke-NUS Medical School, Singapore (2017-present)
  • Chair, SNEC/SERI Business Innovation and Transformation Committee, Singapore National Eye Centre & Singapore Eye Research Institute (2018 – present)
  • President, World Glaucoma Association (2016 – 2017)
  • Member, Academia Ophthalmologica Internationalis (2016 – present)
  • Chairman, National Medical Research Council CS-IRG Local Review Panel (2014 - 2018
  • Board of Governors, World Glaucoma Association (2013 - present)
  • Member, Glaucoma Research Society (2009 – present)
  • Board member, Asia-Pacific Glaucoma Society and President, Asian Angle Closure Glaucoma Club
  • Member, Editorial Boards of Ophthalmology, Progress in Retina and Eye Research, Journal of Glaucoma, Eye,
  • Graefe’s Archive for Clinical and Experimental Ophthalmology, and 6 other journals

Awards

  • Singapore Translational Research (STaR) Investigator Award, National Medical Research Council, Singapore (2020)
  • Fellow, ARVO (FARVO, Gold) (2019)
  • College Medal and Lecture, 28th Annual Scientific Congress of the College of Ophthalmologists of Sri Lanka (2019)
  • Visionary Award, Eye and Vision Health Award (2018)
  • Manuel B. Agulto Award, Philippine Glaucoma Society (2018)
  • SingHealth Duke-NUS Kwan Im Thong Hood Cho Temple Professorship in Ophthalmology (2018)
  • 33rd Asia Pacific Academy Ophthalmology (APAO) Senior Achievement Award (2018)
  • Dr Robert Ritch Award for Excellence & Innovation in Glaucoma, The Glaucoma Foundation, USA (2017)
  • Distinguished Visionary Leader Award, SingHealth Excellence Awards (2016) 
  • Outstanding Researcher Award, NUS University Awards (2016) 
  • Silver Award, ARVO Fellow (2016) 
  • Singapore Translational Research (STaR) Investigator Award, National Medical Research Council, Singapore (2014) 
  • Senior Achievement Award, American Academy of Ophthalmology (AAO) (2014) 
  • Alcon Research Institute Award (2013) 
  • De Campo Lecture Award, Asia-Pacific Academy of Ophthalmology (2013)
  • Faculty Outstanding Researcher Award, Yong Loo Lin School of Medicine, National University of Singapore (2012)
  • Achievement Award, Asia-Pacific Academy of Ophthalmology (APAO) (2010)
  • President’s Science Award, A-STAR, Singapore (2009)
  • GCEO Excellence Award in Biomedical Research, SingHealth (2009) 
  • Biomedical Research Council Clinician Scientist Award (Senior Category), National Medical Research Council (2008)
  • Distinguished Achievement Award, American Academy of Ophthalmology (AAO) (2008)
  • Nakajima Award and Lecture, Asia-Pacific Academy of Ophthalmology (APAO) (2007)
  • Biomedical Research Council Clinician Scientist Investigator Award (Junior Category), National Medical Research Council (2005)
  • ARVO / Santen Pharmaceutical Travel Fellowship Award, ARVO (2001) 
  • Medical Research Fellowship, National Medical Research Council Singapore Totalisator Board (2000)
  • Grace Ballas Travelling Fellowship, National Medical Research Council, Singapore (1997)

Research Interests

  • Ophthalmic Genetics
  • Glaucoma: angle closure glaucoma, glaucoma imaging, clinical trials in glaucoma

Publications

  1. Genetics of Glaucoma in People of African Descent (GGLAD) Consortium., Hauser MA, Allingham RR, Aung T, Van Der Heide CJ, Taylor KD, Rotter JI, Wang SJ, Bonnemaijer PWM, Williams SE, Abdullahi SM, Abu-Amero KK, Anderson MG, Akafo S, Alhassan MB, Asimadu I, Ayyagari R, Bakayoko S, Nyamsi PB, Bowden DW, Bromley WC, Budenz DL, et al. Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry. JAMA. 2019 Nov 5;322(17):1682-1691.

  2. He M, Jiang Y, Huang S, Chang DS, Munoz B, Aung T, Foster PJ, Friedman DS.
    Laser peripheral iridotomy for the prevention of angle closure: a single-centre, randomised controlled trial. Lancet. 2019 Apr 20;393(10181):1609-1618.

  3. Jonas JB, Aung T, Bourne RR, Bron AM, Ritch R, Panda-Jonas S. Glaucoma. Lancet. 2017 Nov 11;390(10108):2183-2193.

  4. Aung T, Ozaki M, Lee MC, Schlötzer-Schrehardt U, ……… Khor CC. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.
    Nature Genetics. 2017 Jul;49(7):993-1004.

  5. Khor CC, Do T, Jia H, Nakano M, George R, …. Aung T. Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nature Genetics 2016 May;48(5):556-62.

  6. Aung T, Ozaki M, Mizoguchi T, Allingham RR, …. Khor CC. A common variant mapping to CACNA1A is associated with susceptibility to Exfoliation syndrome. Nature Genetics 2015 Apr;47(4):387-92.

  7. Chen Y, Lin Y, Vithana EN, Jia L, Zuo X, Wong TY, Chen LJ, Zhu X, Tam POS, Gong B, Qian S, Li Z, Liu X, Mani B, Luo Q, Guzman C, Leung CKS, Li X, Cao W, Yang Q, Tham CCY, ChengY, Zhang X, Wang N, Aung T, Khor CC, Pang CP, Sun X, Yang Z. Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma. Nature Genetics 2014; 46(10): 1115-9.

  8. Weinreb RN, Aung T, Medeiros FA. The Pathophysiology and Treatment of Glaucoma: A Review.
    JAMA. 2014 May 14;311(18):1901-11

  9. Hysi PG, Cheng CY, Springelkamp H, Macgregor S, ………..Aung T. Genome-wide Analysis of Multiethnic Cohorts Identifies Four New Loci Influencing Susceptibility to Increased Intraocular Pressure and Susceptibility to Glaucoma. Nature Genetics- 2014; 46(10): 1126-30.

  10. Nongpiur ME, Khor CC, Jia H, Nair KS, …. Aung T. ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma. PLoS Genet. 2014; 10(3): e1004089.

  11. Vithana EN, Khor CC, Qiao C, Nongpiur ME, ……… Aung T. Genome-wide association analyses identify three new susceptibility loci for Primary Angle Closure Glaucoma. Nature Genetics. 2012 Oct;44(10):1142-6.

  12. Vithana EV, Morgan P, Sundaresan P, Ebenezer N…….., Aung T. Mutations in Na-borate co-transporter SLC4A11 cause recessive Congenital Hereditary Endothelial Dystrophy, CHED2. Nature Genetics, 2006; 38: 755-7.

Research Trials

Current Research Funding Support

  • Singapore Angle Closure Glaucoma Program: From Genetics to Precision Medicine and Therapy (NMRC): PI.
  • Whole Exome Sequencing of Indian Subjects with Primary Angle Closure Glaucoma (SingHealth): PI.
  • Lamina Cribrosa Biomechanics: A Diagnostic Biomarker for Glaucoma? (Ministry of Education): PI.
  • Harnessing LOXL1 as a therapeutic candidate for exfoliation syndrome and exfoliation glaucoma (NMRC): PI.
  • SERI Santen Strategic Collaboration and Joint Ophthalmic Research Laboratory (NMRC-IAF): Lead PI.
  • Singapore Imaging Eye Network SIENA (NMRC): Co-PI.
  • Whole Exome Sequencing to Identify Actionable Mutations Causative of Primary Angle Closure Glaucoma (NMRC): PI.
  • Roles of regulatory variants for LOXL1 in Pseudoexfoliation Glaucoma (Duke-NUS): Co-PI.
  • Characterizing the role of CACNA1 in exfoliation syndrome and glaucoma (NMRC): PI.
  • Singapore Angle Closure Glaucoma Program: characterization, prevention and management (NMRC): PI.

 

Commercial Research Grants

  • A phase III, randomized, observer-masked, active-controlled, parallel-group, multinational and multicentre study assessing the safety and efficacy of DE-117 ophthalmic solution 0.002% compared with latanoprost ophthalmic solution 0.005% in subjects with open-angle glaucoma or ocular hypertension- PEONY study (Santen Pharmaceutical Co., Ltd.)