Dr Najjar obtained his PhD in Neuroscience from the University of Lyon, France and did his postdoctoral training at Stanford University, USA. He has a broad background in neuroscience, circadian rhythms, photobiology, and vision and sleep research, with specific expertise in key techniques in these fields. Dr Najjar’s research focused not only on understanding the non-visual impact of light on physiology and behaviour, but also on technical applications related to this matter. Within that framework, he contributed to the contemporary understanding of the non-image-forming impacts of light detected by the retina, and led studies in the Antarctic, Stanford and France, to successfully implement spectrally and temporally tuned light regimens, to alleviate chronobiological disorders and associated health decrements.
Dr Najjar’s current clinical projects revolve around the development and implementation of original strategies utilizing artificial intelligence and custom-built handheld devices for screening and diagnosing ocular and neurological diseases. His ongoing experimental work focuses on understanding the neurobiology behind the light-based control of myopia and the development of non-invasive photic countermeasures to the worldwide myopia epidemic.
Dr Najjar has received several merit awards and was invited to lecture in various international meetings. He has also assumed different teaching responsibilities in sleep and vision.
Biousse V, Newman NJ, Najjar RP*, Vasseneix C, …, Milea D, for the BONSAI Group, Optic disc classification by deep learning versus expert neuro‐ophthalmologists. Annals of Neurology 2020. JIF : 9.8, Times Cited: NA * Equal contribution.
Milea, D*, Najjar RP*, …, Wong TY*, Biousse V*, for the BONSAI Group, Artificial Intelligence to Detect Papilledema from Ocular Fundus Photographs. N Engl J Med. 2020; 382:1687-1695. JIF : 70.8, Times Cited: 13 * Equal contribution.
Milea D, Singhal S, Najjar RP. Artificial intelligence for detection of optic disc abnormalities. Current Opinion in Neurology. 2020; 33, 1, 106-110. JIF: 4.6, Times Cited: 2.
Teikari P, Najjar RP, Schmetterer L, Milea D. Embedded deep learning in ophthalmology: Making ophthalmic imaging smarter. Therapeutic Advances in Ophthalmology. 2019 11:2515841419827172. JIF: NA, Times Cited: 7.
Chougule P, Najjar RP, Finkelstein M, Nagaendran K, Milea D. Light-Induced Pupillary Responses in Alzheimer’s Disease. 2019, Front. Neurol. 10, 360. JIF: 3.5, Times Cited: 4.
Rukmini AV, Chew M, Finkelstein M, Atalay E, Baskaran M, Nongpiur ME, Gooley JJ, Aung T, Milea D, Najjar RP. Effects of low and moderate refractive errors on chromatic pupillometry. Sci Reports. Mar 2019;7(1):10190 JIF: 4.3, Times Cited: 0.
Calligaro H, Coutanson C, Najjar RP, Mazzaro N, Cooper HM, Haddjeri N, Felder-Schmittbuhl M-P, Dkhissi-Benyahya O. Rod photoreceptors are required for the light-induced phase shift of the retinal clock in mammals. PloS Biology. 2019, 1;17(3):e2006211. JIF: 9.2, Times Cited: 5.
Prayag A, Najjar RP, Gronfier C. Melatonin suppression is exquisitely sensitive to light and primarily driven by melanopsin in humans. Journal of Pineal Research. 2019 May;66(4):e12562. JIF: 15.2, Times Cited: 27.
Najjar RP, Reynier P, Caignard A, Procaccio V, Amati-Bonneau P, Mack H, Milea D. Retinal Neuronal Loss in Visually Asymptomatic Patients with Myoclonic Epilepsy with Ragged-Red Fibers (MERRF) Journal of Neuro-ophthalmology. 2019 Mar;39(1):18-22. JIF: 2.0, Times Cited: 2.
Najjar RP, Sharma S, Atalay E, Rukmini AV, Sun C, Lock J-Z, Baskaran M, Perera SA, Husain R, Gooley JJ, Lamoureux E, Aung T, Milea D. Pupillary responses to full-field chromatic stimuli are reduced in patients with early-stage primary open-angle glaucoma. Ophthalmology. Sept 2018;125(9):1362-71. JIF: 8.2, Times Cited: 16.
Rukmini AV, Najjar RP, Atalay E, Sharma S, Lock JZ, Baskaran M, Nongpiur M, Gooley JJ, Aung T, Milea D. Pupillary responses to light are not affected by narrow irido-corneal angles. Sci Reports. Aug 2017;7(1):10190 JIF: 4.3, Times Cited: 3.
Najjar RP, Sharma S, Drouet M, Leruez S, Baskaran M, Nongpiur ME, White O, Fielding J, Lamirel C, Milea D. Disrupted Eye Movements in Preperimetric Primary Open-Angle Glaucoma. Invest Ophthalmol Vis Sci. Apr 2017;58: 2430–37. JIF: 3.7, Times Cited: 10.
Najjar RP, Zeitzer JM, 2017, Anatomy and Physiology of the Circadian System, Mitchell G. Miglis, in Sleep and Neurologic Disease, San Diego: Academic Press, 1, 29–53. Times Cited: 4.
Sharma S, Ang M, Najjar RP, Sng C, Cheung CY, Rukmini AV, Schmetterer L, Milea D. Optical coherence tomography angiography in acute non-arteritic anterior ischaemic optic neuropathy. Br J Ophthalmol. Aug 2017;101: 1045–51; JIF: 3.8, Times Cited: 55.
Hung SM, Milea D, Rukmini DV, Najjar RP, Tan JH, Viénot F, Dubail M, Tow SLC, Aung T, Gooley JJ, Hsieh P-J. Cerebral Neural Correlates of Melanopsin-based Photoreception in Humans, Neuroimage, Feb 2017;146: 763–69, JIF: 6.8, Times Cited: 15.
McBean AL*, Najjar RP*, Schuchard RA, Hall CD, Wang C-A, Ku B, Zeitzer JM. Standing Balance and Spatiotemporal Aspects of Gait Are Impaired Upon Nocturnal Awakening in Healthy Late Middle-Aged and Older Adults. J Clin Sleep Med. Nov 2016; 12(11): 1477–86. JIF: 2.7, Times Cited: 6.
Najjar RP, Teikari P, Cornut PL, Knoblauch K, Denis P, Cooper HM, Gronfier C. Heterochromatic Flicker Photometry for Objective Lens Density Quantification. Invest Ophthalmol Vis Sci. Mar 2016;57(3):1063-71. JIF: 3.7, Times Cited: 17.
Najjar RP, Zeitzer JM. Temporal integration of light flashes by the human circadian system (Clinical Trial). J Clin Invest. Feb 2016;126(3):938-47. JIF: 14.1, Times Cited: 40.
Najjar RP, Wolf L, Taillard J, Schlangen LJM, Salam A, Cajochen C, Gronfier C. Chronic artificial blue-enriched white light is an effective countermeasure to delayed circadian phase and neurobehavioral decrements. PLoS ONE, Jul 2014; 9:e102827. JIF: 4.24, Times Cited: 65.
Najjar RP, Chiquet C, Teikari P, Cornut P-L, Claustrat B, Denis P, Cooper HM, Gronfier C. Aging of non-visual spectral sensitivity to light in humans: compensatory mechanisms? PLoS ONE, Jan 2014; 9:e85837. JIF: 4.2, Times Cited: 81.
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