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Dr Liu Yu Chi from Singapore National Eye Centre

Dr Liu Yu-Chi


Clinician Scientist

Singapore National Eye Centre

Specialty: Corneal & External Eye Disease

Sub-specialties: Corneal & External Eye Disease

Clinical Appointments

  • Clinician Scientist Corneal & External Eye Disease Department Singapore National Eye CentreSingapore National Eye Centre

Academic Appointments

  • Assistant Professor SingHealth Duke-NUS Ophthalmology & Visual Sciences Academic Clinical Programme


Dr Liu Yu-Chi obtained her medical degree (MD) from Taipei Medical University, Taiwan in 2005. She gained her specialist accreditation in Ophthalmology in 2009 and completed her fellowship training in Cornea and External Eye Diseases in Taiwan as well as her Master of Clinical Investigation (MCI) from National University of Singapore (NUS) in 2015.

Dr Liu was awarded Dean’s List for academic excellence in 2001-2004, the Best Intern Award in 2005, and Best Poster Award in 2007-2009 in Taiwan. Her clinical and research work were also recognized with national awards in Singapore, including the Ministry of Health (MOH) Healthcare Research Award (MOH, Singapore, 2013), the ExxonMobil-NUS Research Fellowship for Clinician Award (NUS, Singapore, 2013), and the Transition Award for clinician scientists (National Medical Research Council, Singapore, 2017); as well as international awards, such as the World Ophthalmology Congress (WOC) Travel Grant Award (2014), and the 1st Prize Presentation Award, European Society of Cataract and Refractive Surgeons Congress (ESCRS, 2015).

Dr Liu’s clinical and research interests are in the areas of corneal diseases, corneal transplantation and refractive surgery. She is the author of the international textbooks on Cornea and Refractive surgery, and the editor and reviewer of ophthalmology journals. She has published more than 45 papers spanning from clinical studies to translational research in peer-reviewed, international journals, including one publication in the prestigious journal “Lancet”. Dr Liu also has given more than 50 invited talks or presentations in international meetings.

Dr Liu has been awarded multiple research grants from the National Medical Research Council, SingHealth, NUS and Duke-NUS Medical School. She also actively mentors medical students, residents and fellows and currently holds the appointment as Instructor at the Duke-NUS Medical School.


  • MCI (2015)
  • MD (2005)

Professional Appointments and Committee Memberships

  • Woman in Ophthalmology, USA (2018 - present)

  • Member, Asian Dry Eye Society (2016 – present)

  • Member, European Society of Cataract & Refractive Surgeons (2015 – present)

  • Member, Asian Corneal Society (2014 – present)

  • Member, American Society of Cataract and Refractive Surgeons (USA) (2013 – present)

  • Member, American Academy of Ophthalmology (USA) (2012 – present)

  • Member, Association for Research in Vision and Ophthalmology (USA) (2010 – present)


  • Achievement Award, Asia-Pacific Academy of Ophthalmology(2019)

  • Distinguished Young Researcher Award, SingHealth(2019)

  • National Medical Research Council Fellowship/Scholarship, Singapore(2018)

  • Transition Award, National Medical Research Council, Singapore(2017)

  • 1st Prize Presentation Award, European Society of Cataract and Refractive Surgeons (ESCRS) Congress(2015)

  • Outstanding Fellow Award, Singapore Eye Research Institute(2015)

  • Travel Grant Award, World Ophthalmology Congress (WOC) (2014)

  • ExxonMobil-NUS Research Fellowship for Clinicians Award(2013)

  • Healthcare Research Scholarship Award, Ministry of Health(2013)

  • First in National Board Ophthalmology Examination, Taiwan (2009)

  • Best Resident Oral Presentation, 48th Annual Meeting of Taiwan Ophthalmological Society(2008)

  • Academic Top Scholarship (class standing: number one), Taipei Medical University, Taiwan(2003)

  • Excellent Scholarship (class standing: top five), Shui-Wang Ho Medical Foundation, Taipei Medical University, Taiwan (2001-2004)

Research Interests

  • Cornea and External Eye Diseases

  • Refractive surgery

  • Clinical Trial


  1. Liu YC, Jung A, Jia AJS, Yang LWY, Mehta JS. Cross-sectional study on denervation in contralateral eyes following small incision lenticule extraction versus laser-assisted in-situ keratomileusis.  J Refract Surg 2020; In Press.

  2. Chin JY, Yang LWY, Ji AJS, Nubile M, Mastropasqua L, Allen JC, Mehta JS, Liu YC. Validation of the use of automated and manual quantitative analysis of corneal nerve plexus following refractive surgery. Diagnostics 2020; 10(7):493.

  3. Liu YC, Ang M, Ong HS, Wong TY, Mehta JS. SARS-CoV-2 infection in conjunctival tissue. Lancet Respir Med 2020;87(7):e57.

  4. Yi Teo HY, Ong HS, Liu YC, Tong L. Meibomian gland dysfunction is the primary determinant of dry eye symptoms: Analysis of 2346 patients. Ocul Surf 2020; S1542-0124(20)30105-1.

  5. Liu YC, TY Lin, Mehta JS. Analysis of corneal nerve plexus in corneal confocal microscopy images. Neural Regen Res 2020; doi: 10.4103/1673-5374.289435.

  6. Liu YC, Jung SJ, Tan TE, Fuest M, Mehta JS. Femtosecond laser-assisted preparation of conjunctival autograft for pterygium surgery. Sci Rep 2020;10(1):2674.

  7. Liu YC, Hall B, Lwin NC, Teo EPW, Yam GHF, Hipsley A, Mehta JS. Tissue responses and wound healing following laser scleral microporation for presbyopia therapy. Trans Vis Sci Tech 2020; 9(4):6.

  8. Riau AK, Liu YC, Yam GYH, Mehta JS. Stromal keratophakia: corneal inlay implantation. Prog Retin Eye Res 2020;75:100780.

  9. F Bandeira, Yam GYH, Liu YC, Devarajan K. Mehta JS. Three dimensional neurite characterization of small incision lenticule extraction derived lenticules. Invest Ophthal Vis Sci  2019; 60(13):4408-15.

  10. Liu YC, Devarajan K, Tan TE, Ang M, Mehta JS. Optical coherence tomography angiography for evaluation of reperfusion following pterygium surgery. Am J Ophthalmol 2019;pii: S0002-9394(19)30152-7.

  11. Liu YC, Vittwer VV, Yusoff NZB, Lwin CN, Seah XY, Mehta JS. Intraoperative optical coherence tomography-guided femtosecond laser-assisted deep anterior lamellar keratoplasty. Cornea 2019;38(5):648-653.

  12. Liu YC, Setiawan M, Ang M, Yam GYH, Mehta JS. Changes in aqueous oxidative stress, prostaglandin, and cytokines: comparisons of low-energy femtosecond laser-assisted cataract surgery versus conventional phacoemulsification. J Cataract Refract Surg 2019;45:196-203.

  13. Liu YC, Teo EPW, Ang HP, Seah XY, Lwin NC, Yam GH, Mehta JS. Biological corneal inlay for presbyopia derived from small incision lenticule extraction. Sci Rep 2018;8:1831.

  14. Liu YC, Ng XW, Teo EPW, Ang HP, Nyein CL, Chan SW, Venkatraman SS, Wong TT, Mehta JS. A biodegradable, sustained-released, tacrolimus microfilm drug delivery system for the management of allergic conjunctivitis in a mouse model. Invest Ophthalmol Vis Sci 2018,59:675-684. 

  15. Liu YC, Wilkins M, Kim T, Malyugin B, Mehta JS. Cataracts. Lancet 2017;390(10094):600-612.

  16. Liu YC, Rosman M, Mehta JS. Enhancement following small incision lenticule extraction (SMILE): incidence, risk factors, and outcomes. Ophthalmology 2017;124(6):813-21.

  17. Liu YC, Williams GP, George BL, Soh YQ, Seah XY, Peh GSL, Yam GJ, Mehta JS. Corneal lenticule storage prior to re-implantation. Mol Vis 2017;23:753-764.

  18. Liu YC, Ng NC, Ng XW, Peng Y, Venkatraman SS, Wong TT, Mehta JS. Evaluation of s sustained-release prednisolone acetate biodegradable subconjunctival implant in a non-human primate model. Trans Vis Sci Tech 2017;6(5):9.

  19. Fuest M, Liu YC, Yam GH, Teo PW, Htoon HM, Coroneo MT, Mehta JS. Femtosecond laser assisted    conjunctical autograft preparation for pterygium surgery. Ocul Surf 2016 Dec 2. pii: S1542-0124(16)30112-4.

  20. Liu YC, Ang HP, Teo PW, Lwin NC, Yam GH, Mehta JS. Wound healing profiles of hyperopic-small incision lenticule extraction (SMILE). Sci Rep 2016;6:29806.

Research Trials

  • Evaluation of corneal nerves with confocal microscopy imaging systems (2020-Present)

  • Artificial intelligence in corneal diseases and refractive surgery (2019-Present)

  • Phase IIa clinical trial on the use of biological inlay for presbyopia treatment (2019-Present)

  • Corneal nerve regeneration after refractive surgery (2018-Present)

  • Clinical outcomes of femtosecond laser-assisted pterygium surgery (2017-Present)

  • Comparison of clinical outcomes of Ziemer LDV Z8 femtosecond laser-assisted cataract surgery versus conventional phacoemulsification cataract surgery (2017-Present)

  • The applications of Terahertz scanning system on corneas (2017-Present)

  • Evaluation of safety and efficacy of tacrolimus-loaded liposomal drug delivery system in the treatment of allergic conjunctivitis (2016-Present)

  • Evaluation of the efficacy of novel treatment for presbyopia, scleral Er:YAG laser procedure (2016-Present)