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Dr Liu Yu Chi from Singapore National Eye Centre

Dr Liu Yu-Chi


Clinician Scientist

Singapore National Eye Centre

Specialty: Corneal & External Eye Disease

Sub-specialties: Corneal & External Eye Disease

Clinical Appointments

  • Clinician Scientist Corneal & External Eye Disease Department Singapore National Eye CentreSingapore National Eye Centre

Academic Appointments

  • Instructor SingHealth Duke-NUS Ophthalmology & Visual Sciences Academic Clinical Programme


Dr Liu Yu-Chi obtained her medical degree (MD) from Taipei Medical University, Taiwan in 2005.  She gained her specialist accreditation in Ophthalmology in 2009 and completed her fellowship training in Cornea and External Eye Diseases in Taiwan as well as her Master of Clinical Investigation (MCI) from National University of Singapore (NUS) in 2015.

Dr Liu was awarded Dean’s List for academic excellence in 2001-2004, the Best Intern Award in 2005, and Best Poster Award in 2007-2009 in Taiwan. Her clinical and research work were also recognized with national awards in Singapore, including the Ministry of Health (MOH) Healthcare Research Award (MOH, Singapore, 2013), the ExxonMobil-NUS Research Fellowship for Clinician Award (NUS, Singapore, 2013), and the Transition Award for clinician scientists (National Medical Research Council, Singapore, 2017); as well as international awards, such as the World Ophthalmology Congress (WOC) Travel Grant Award (2014), and the 1st Prize Presentation Award, European Society of Cataract and Refractive Surgeons Congress (ESCRS, 2015).

Dr Liu’s clinical and research interests are in the areas of corneal diseases, corneal transplantation and refractive surgery. She is the author of the international textbooks on Cornea and Refractive surgery, and the editor and reviewer of ophthalmology journals. She has more than 45 papers spanning from clinical studies to translational research in peer-reviewed, international journals, including one publication in the prestigious journal “Lancet”. Dr Liu also has more than 50 invited talks or presentations in international meetings.
Dr Liu has been awarded multiple research grants from the National Medical Research Council, SingHealth, NUS and Duke-NUS Medical School. She also actively mentors medical students, residents and fellows and currently holds the appointment as Instructor at the Duke-NUS Medical School.


  • MCI (2015)
  • MD (2005)

Professional Appointments and Committee Memberships

  • Guest Editor, Journal of Ophthalmology (2016 - present)
  • Scientific Review Committee, Asia-Pacific Academy of Ophthalmology Congress (2016 - present)
  • Member, American Society of Cataract and Refractive Surgeons, USA (2012 - present)
  • Member, Association for Research in Vision and Ophthalmology, USA (2009 - present)
  • Member, American Academy of Ophthalmology, USA (2010 - present)
  • Member, Association for Cataract and Refractive Surgery, Taiwan (2008 - present)
  • Member, Taiwan Ophthalmological Society (2008 - present)


  • Transition Award for Clinician Scientist, National Medical Research Council, Singapore (2017)
  • 1st Prize Paper Award, European Society of Cataract & Refractive Surgeons (ESCRS) Congress (2015)
  • Outstanding Fellow Award, Singapore Eye Research Institute (2015)
  • Travel Grant Award, World Ophthalmology Congress (WOC) (2014)
  • Research Fellowship for Clinicians Award, ExxonMobil - NUS (2013)
  • Healthcare Research Scholarship Award, Ministry of Health (2013)
  • Top 1 in National Board Ophthalmology Examination, Taiwan (2009)
  • Best Resident Oral Presentation, 48th Annual Meeting of Taiwan Ophthalmological Society (2008)
  • Best Intern Award, Taipei Veterans General Hospital, Taiwan (2005)
  • Academic Top Scholarship (class standing: number one), Taipei Medical University, Taiwan (2003)
  • Excellent Scholarship (class standing: top five), Shui-Wang Ho Medical Foundation, Taipei Medical University, Taiwan (2001 - 2004)

Publications and Research Trials

  1. Liu YC, Teo PW, Ang HP, Seah XY, Lwin NC, Yam GH, Mehta JS. Biological corneal inlay for presbyopia derived from small incision lenticule extraction. Sci Rep 2018;8:1831

  2. Liu YC, Ng XW, Teo EP, Ang HP, Nyein CL, Chan SW, Venkatraman SS, Wong TT, Mehta JS. A biodegradable, sustained-released, tacrolimus microfilm drug delivery system for the management of allergic conjunctivitis in a mouse model. Invest Ophthalmol Vis Sci 2018,59:675-84

  3. Liu YC, Mehta JS. Re: Re: Liu et al.: Enhancement after small-incision lenticule extraction: Incidence, risk factors, and outcomes. Ophthalmology 2017;124:e84-85 

  4. Liu YC, Williams GP, George BL, Soh YQ, Seah XY, Peh GSL, Yam GJ, Mehta JS. Corneal lenticule storage prior to re-implantation. Mol Vis 2017;23:753-764

  5. Liu YC, Ng NC, Ng XW, Peng Y, Venkatraman SS, Wong TT, Mehta JS. Evaluation of s sustained-release prednisolone acetate biodegradable subconjunctival implant in a non-human primate model. Trans Vis Sci Tech 2017;6(5):9

  6. Liu YC, Wilkins M, Kim T, Malyugin B, Mehta JS. Cataracts. Lancet 2017;390(10094):600-612

  7. Liu YC, Rosman M, Mehta JS. Enhancement following small incision lenticule extraction (SMILE): incidence, risk factors, and outcomes. Ophthalmology 2017;124(6):813-21

  8. Liu YC, Ang HP, Teo PW, Lwin NC, Yam GH, Mehta JS. Wound healing profiles of hyperopic-small incision lenticule extraction (SMILE). Sci Rep 2016;6:29806

  9. Liu YC, Mehta JS. Surgical instruments for small incision lenticule extraction (SMILE). Expert Rev Ophthalmol 2016;11(3):171-2

  10. Liu YC, Teo PW, Lwin NC, Yam GH, Mehta JS. Early corneal wound healing and inflammatory response after small incision lenticule extraction (SMILE): comparison of the effects of effects of different refractive correction and surgical experiences. J Refract Surg 2016; 32:346-53

  11. Liu YC, Konstantopolous A, Riau AK, Bhayani R, Lwin NC, Teo PW, Yam GH, Mehta JS. Repeatability and reproducibility of corneal biometric measurements using the Visante Omni and a rabbit experimental model of post-surgical corneal ectasia. Trans Vis Sci Tech 2015; 4:16

  12. Liu YC, Teo PW, Adnan KB, Yam GH, Peh GH, Tan DT, Mehta JS. Endothelial approach ultrathin corneal grafts prepared by femtosecond laser for Descemet stripping endothelial keratoplasty. Invest Ophthalmol Vis Sci 2014;55:8393-401

  13. Liu YC, Pujara T, Mehta JS. New instruments for small incision lenticule extraction (SMILE). PLOS ONE 2014;9:e113774

  14. Liu YC, Lwin NC, Chan SW, Mehta JS. Use of anterior segment optical coherence tomography to predict corneal graft rejection in small animal models. Invest Ophthalmol Vis Sci 2014;55:6736-41

  15. Liu YC, Alvarez Paraz CM, Cajucom-Uy HY, Agahari D, Sethuraman S, Tan DT, Mehta JS. Risk factors for donor endothelial loss in eye bank-prepared posterior lamellar corneal tissue for descemet stripping automated endothelial keratoplasty. Cornea 2014;33:677-82

  16. Liu YC, Peng Y, Lwin NC, Venkatraman SS, Wong TT, Mehta JS. A Biodegradable, sustained-released, prednisolone acetate microfilm drug delivery system effectively prolongs corneal allograft survival in the rat keratoplasty model. PLoS One 2013;8:e70419

  17. Liu YC, Tsai CC, Lee FL, Lee SM, Kao SC. Mortality from uveal melanoma treated by enucleation— A 16-year survey in Taiwan. Acta Ophthalmol 2013;91:e583-4

  18. Liu YC, Peng Y, Lwin NC, Wong TT, Venkatraman SS, Mehta JS. Optimization of subconjunctival biodegradable microfilms for sustained drug delivery to the anterior segment in a small animal model. Invest Ophthalmol Vis Sci 2013;54:2607-15

  19. Liu YC, Wong TT, Mehta JS. Intraocular lens as a drug delivery reservoir. Curr Opin Ophthalmol 2013;24:53-9 

  20. Liu YC, Chou P, Wojciechowski R, Lin PY, Liu CJ, Chen SJ, Liu JH, Hsu WM, Cheng CY. Power vector analysis of refractive, corneal and internal astigmatism in an elderly Chinese population: the Shihpai Eye Study. Invest Ophthalmol Vis Sci 2011;52:9651-7 

Research Trials

  • Evaluation of the safety and efficacy of biological corneal inlay derived from small incision lenticule extraction (SMILE) for presbyopia: a pilot study, Singapore Eye Research Institute
  • The applications of Terahertz scanning system on corneas, National Medical Research Council, Singapore
  • Comparisons of free radicals produced by conventional phacoemulsification versus nanosecond laser-assisted cataract surgery, Academic Clinical Program, Duke-NUS
  • The use of portable Terahertz system in characterizing corneal components and in analysing hydration profiles in different corneal conditions, SingHealth, Singapore
  • Evaluation of a novel treatment for presbyopia, scleral Er: YAG laser procedure, on its feasibility, optimization and wound healing profiles, SingHealth, Singapore
  • Comparison of clinical outcomes of femtosecond laser versus microkeratome-assisted Descemet stripping automated endothelial keratoplasty (DSAEK), National Medical Research Council, Singapore
  • A Novel Prednisolone Acetate-loaded Microfilm Drug Delivery System Prolongs Corneal Allograft Survival in Corneal Transplantation Surgery, National University of Singapore, Singapore