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Assoc Prof Danny Cheung

Assoc Prof Cheung Danny


Senior Consultant

Singapore National Eye Centre

Specialty: Surgical Retina

Clinical Interest: Surgical Retina

Clinical Appointments

  • Senior Consultant Surgical Retina Department Singapore National Eye CentreSingapore National Eye Centre
  • Senior Consultant SNEC Eye Clinic @ CGH Changi General HospitalChangi General Hospital

Academic Appointments

  • Associate Professor SingHealth Duke-NUS Ophthalmology & Visual Sciences Academic Clinical Programme


Associate Professor Danny Cheung is a Senior Consultant ophthalmologist with the Cataract and Comprehensive Ophthalmology and Surgical Retina Departments at the Singapore National Eye Centre. He specialises in the management of cataract as well as both medical and surgical retinal conditions. He is also a Senior Faculty and Associate Professor with the SingHealth Duke-NUS Ophthalmology & Visual Sciences Academic Clinical Program.

Associate Professor Cheung completed his undergraduate medical degree from the University of Melbourne, Australia in 2004, and subsequently obtained his postgraduate degree for Doctor of Medicine (Ophthalmology) from the same university. He was trained as a general ophthalmologist at the Royal Victorian Eye and Ear Hospital in Melbourne, and received his Australian Specialist qualification in 2013. In addition, he completed four years of subspecialty fellowships in retinal diseases, including two years in Hong Kong and the other two at the Singapore National Eye Centre.

Associate Professor Cheung is also a clinician-scientist at the Singapore Eye Research Institute, with strong interests in retinal research and an excellent academic track record in the fields of ophthalmic epidemiology, retinal imaging, diabetic retinopathy and surgical retinal diseases. He has published over 130 scientific papers and several book chapters. These include articles in prestigious high-impact journals such as the Lancet, British Medical Journal, Diabetes Care, Brain, Annals of Neurology, and Progress in Retinal and Eye Research. His publications are well cited, with a personal H-index of 46. He is currently a leading investigator for a number of major eye studies in Singapore, including clinical trials on neuroprotective therapy for retinal detachment, and surgical management for epiretinal membrane (macular pucker). He is also involved in clinical and laboratory studies on novel therapeutic targets for other common sight-threatening retinal diseases, such as diabetic retinopathy, age-related macular degeneration and retinal vein occlusion. His research work has received national and international recognitions with several prestigious awards, such as the Australian Society for Medical Research High Commendation, Bayer’s Global Ophthalmology Award, Diabetes Research Innovation Award, and the National Medical Research Council Clinician-Scientist Award and the SingHealth Outstanding Research Award in Singapore.

Associate Professor Cheung highly values quality in patient care, education and research. As an experienced cataract surgeon, he performs regular and complex cataract surgeries, offering intraocular lens implants such as multi-focal and toric lenses to suit patient’s specific visual needs. As an experienced retinal surgeon, he also treats many patients with retinal diseases, including macular pucker (epiretinal membrane), macular hole, retinal detachment, diabetic retinopathy and age-related macular degeneration. He truly cherishes his time with all his patients and considers a real privilege to be able to provide them with patient-centred and evidence-based eye care in a compassionate manner. Lastly, Associate Professor Cheung also devotes considerable time and passion in conducting translational eye research that aims to bring new scientific discoveries to clinical application, with an ultimate goal to improve treatment and outcome of many sight-threatening eye diseases.


  • MD(Ophth) (2015)
  • FRANZCO (2013)
  • MBBS (2004)
  • BMedSc (2004)

Professional Appointments and Committee Memberships

  • Member, American Academy of Ophthalmology (AAO) (2017 - present)
  • Member, Royal Australia and New Zealand College of Ophthalmologist (2013 - present)


  • Clinician-Scientist Award, National Medical Research Council (2020)\

  • Travel Grant, The Association for Research in Vision and Ophthalmology (ARVO) (2018)

  • Outstanding Research Award, SingHealth (2017)

  • Transition Award, National Medical Research Council (2015)

  • Global Ophthalmology Award (Clinical Training), Bayer (2012)

  • Royal Australia and New Zealand College of Ophthalmology Scholarship (2012)

  • High Commendation, Australian Society for Medical Research (2011)

  • Progress in Retinal and Eye Research – Top Cited Article (2008 - 2010)

  • Travel Grant, Pfizer Cardiovascular (2010)

  • Translational Clinical Research in Major Eye Disease Fellowship Grant (2010)

  • Diabetes Research Innovation Award (2009)

  • Heart Foundation Travel Grant (2008)

  • Best Poster Award, American Academy of Ophthalmology (AAO) (2007)

  • Travel Award, Juvenile Diabetes Research Foundation (2007)

  • Most Creative Paper Award – Multi-Ethnic Study of Atherosclerosis (2007)

  • Travel Fellowship, The Association for Research of Vision and Ophthalmology (ARVO) (2007)

  • Hugh Noel Puckle Scholarship (2007)

  • Travel Award, Centre for Eye Research (2006)

Research Interests

  • Ophthalmic epidemiology
  • Retinal detachment
  • Diabetic retinopathy
  • Epiretinal membrane
  • Retinal image analysis


  1.  Cheung N, et al. Will the myopia epidemic lead to a retinal detachment epidemic in the future? JAMA Ophthalmology. 2021;139:93-94

  2. Cheung N, et al. Prevalence and associations of retinal emboli with ethnicity, stroke, and renal disease in a multi-ethnic Asian population: the Singapore Epidemiology of Eye Disease Study. JAMA Ophthalmology. 2017;135:1023-28

  3. Cheung N, Tan SP, Lee SY, et al. Prevalence and risk factors for epiretinal membrane: the Singapore Epidemiology of Eye Disease Study. British Journal of Ophthalmology 2016; In Press

  4. Cheung N, et al. Anti-vascular endothelial growth factor for diabetic retinopathy: overview of clinical efficacy and evolving applications. Diabetes Care. 2014;37:900-5

  5. Cheung N, Lam DS, Wong TY. Anti-vascular endothelial-growth-factor therapy for eye diseases. British Medical Journal. 2012;344:e2970

  6. Cheung N, Wong TY. Predicting risk of diabetic retinopathy from retinal vessel analysis: personalized medicine in transition. JAMA Ophthalmology. 2012;130:783-4

  7. Cheung N, Wong TY. Changing trends of blindness: the initial harvest from translational public health and clinical research in ophthalmology. American Journal of Ophthalmology. 2012;153:193-5

  8. Cheung N, et al. Retinal fractals and acute lacunar stroke. Annals of Neurology 2010;68:107-11

  9. Cheung N, et al. Retinal microvascular abnormalities and subclinical magnetic resonance imaging brain infarct – a prospective study. Brain 2010;133:1987-93

  10. Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010;376:124-36

  11. Cheung N, Donaghue KC, Liew G, et al. Quantitative assessment of early diabetic retinopathy using fractal analysis. Diabetes Care 2009;32:106-10

  12. Cheung N, Lim L, Wang JJ, et al. Prevalence and risk factors for retinal arteriolar emboli in an Asian population. American Journal of Ophthalmology. 2008;146:620-4

  13. Cheung N, Wong TY. Fenofibrate and diabetic retinopathy. Lancet. 2008;371:721-2

  14. Cheung N, Wong TY. Diabetic retinopathy and systemic vascular complications. Progress in Retinal and Eye Research. 2008;27:161-76

  15. Cheung N, Klein R, Wang JJ, Cotch MF, Islam FM, Klein BEK, Cushman M, Wong TY. Prevalence and risk factors for retinal vein occlusion: the Multi-Ethnic Study of Atherosclerosis. Investigative Ophthalmology and Visual Science. 2008;49:4297-302

  16. Cheung N, Wang JJ, Brancati F, et al. Diabetic retinopathy and risk of heart failure: the Atherosclerosis Risk in Communities Study. Journal of the American College of Cardiology 2008;51:1573-8

  17. Cheung N, Rogers SL, Donaghue KC, et al. Retinal arteriolar dilation predicts retinopathy in type 1 diabetes. Diabetes Care 2008;31:1842-6

  18. Cheung N, Shankar A, Klein R, et al. Age-related macular degeneration and risk of cancer mortality. JAMA Ophthalmology 2007;125:1241-7

  19. Cheung N, Wong TY. Obesity and Eye Diseases. Survey of Ophthalmology 2007;52:180-95

  20. Cheung N, Rogers S, Couper DJ, et al. Is diabetic retinopathy an independent risk factor for ischemic stroke? Stroke 2007;38:398-401

Research Trials

Leading Investigator for the following studies:

  • Optimising surgical management and patient-related outcomes of epiretinal membrane: predictive analytics and randomised trial
  • Randomised controlled trial of lutein as a novel neuroprotective adjunctive therapy to improve visual outcome of rhegmatogenous retinal detachment (LUNAR Study)

  • Diabetic Retinopathy Tear (DART) Study

  • Using optical coherence tomography angiography to study the effect of vitrectomny and membrane peeling surgery on macular perfusion (OCTA-ERM Study)

  • Ocular biomarker study for retinal angiogenic diseases (OBSRAD Study)

  • Developing a novel retinopexy device for retinal detachment surgery


Co-investigator for the following studies:

  • A two-year randomized, double-masked, multicentre, two-arm study comparing the efficacy and safety of RTH258 6mg versus aflibercept in subjects with neovascular age-related macular degeneration

  • A randomized, open-label phase 2 trial of ponatinib in patients with resistant chronic phase chronic myeloid leukemia to characterize the efficacy and safety of a range of doses

  • Novel multimodal imaging in moderate diabetic retinopathy to predict vision-threatening stages of retinopathy

  • Assessing the impact of vitrectomy on the macular vascular structure and function in patients with diabetic retinopathy

  • A longitudinal study on the structural-functional correlations of perifoveal capillary network integrity in diabetes using optical coherence tomography angiography

  • Identifying ocular and systemic biomarkers for response to aflibercept in Asian patients with centre involving diabetic macular edema: a prospective interventional trial

  • Vitreo-retinal interface abnormalities as detected on optical coherence tomography: epidemiology and association with distance vision and health related quality of life

  • Effect of ranibizumab on pigment epithelial detachment in neovascular age-related macular degeneration

  • Novel vascular imaging in diabetic retinopathy: an optical coherence tomography angiogram study

  • Safety and efficacy of Abicipar Pegol in patients with neovascular age-related macular degeneration