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Glaucoma Research Group


Overview

Primary Angle Closure Glaucoma
Goal: To improve understanding and management of primary angle closure glaucoma (PACG)

Our current research includes the evaluation and phenotypic characterisation of primary angle closure glaucoma patients, improved screening modalities for angle closure and better management of the disease. An ongoing clinical trial aims to compare laser iridotomy (LI) with no treatment in subjects with asymptomatic narrow angles, the anatomical trait that predisposes to PACG. This will assess the effectiveness of prophylactic treatment in preventing blindness due to PACG.


Glaucoma Imaging and Clinical Research
Goal: To develop enhanced imaging modality and treatments for glaucoma

This group encompasses research that involves the evaluation of various imaging devices (e.g. Ultrasound Biomicroscopy (UBM), optical coherence tomography, Retcam etc), studies on medical, laser and surgical management of glaucoma and epidemiological studies. We also evaluate new techniques in glaucoma, such as pupillometry, motion detection perimetry, 24-hour IOP monitoring and Oxymap.


Glaucoma Genetics

Goal: To identify gene(s) underlying glaucoma

Our current research involves the identification of novel loci for PACG and POAG, both monogenic and polygenic, by traditional family-based linkage, candidate gene and genome wide association analyses. Recently, we identified three novel genetic loci in PACG. We will be following up with patients to evaluate these and other loci in profiling genetic and anatomical risks for progression. Furthermore, we are characterising the genetic loci in PACG in cell lines as we hope to identify molecular targets of importance in pathogenesis and the management of PACG.


Biomechanics and Glaucoma
Goal: To develop biomarkers using biomechanical properties of tissues in the anterior segment and Optic nerve head, related to glaucoma

Research related to biomechanics of optic nerve head and anterior segment tissues is the main focus of a team of scientists from NUS and SERI. Several studies in primates and humans are being conducted to evaluate these properties and efforts are being made to find their association to the diagnosis of types of glaucoma and prognosis related to progression and management.


Publications

  1. Trikha S, Saffari E, Nongpiur M, Baskaran M, Ho H, Li Z, Tan PY, Allen J, Khor CC, Perera SA, Cheng CY, Aung T, Vithana E. A Genetic Variant in TGFBR3-CDC7 Is Associated with Visual Field Progression in Primary Open-Angle Glaucoma Patients from Singapore. Ophthalmology. 2015 Sep 14.

  2. Thakku SG, Tham YC, Baskaran M, Mari JM, Strouthidis NG, Aung T, Cheng CY, Girard MJ. A Global Shape Index to Characterize Anterior Lamina Cribrosa Morphology and Its Determinants in Healthy Indian Eyes. Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3604-14.

  3. Baskaran M, Foo RC, Cheng CY, Narayanaswamy AK, Zheng YF, Wu R, Saw SM, Foster PJ, Wong TY, Aung T. The Prevalence and Types of Glaucoma in an Urban Chinese Population: The Singapore Chinese Eye Study. JAMA Ophthalmol. 2015 May 14.

  4. Li Z, Allingham RR, Nakano M, Jia L, Chen Y, Ikeda Y, Mani B, Chen LJ, Kee C, Garway-Heath DF, Sripriya S, Fuse N, Abu-Amero KK, Huang C, Namburi P, Burdon K, Perera SA, Gharahkhani P, Lin Y, Ueno M, Ozaki M, Mizoguchi T, Krishnadas SR, Osman EA, Lee MC, Chan AS, Tajudin LS, Do T, Goncalves A, Reynier P, Zhang H,Bourne R, Goh D, Broadway D, Husain R, Negi AK, Su DH, Ho CL, Blanco AA, LeungCK, Wong TT, Yakub A, Liu Y, Nongpiur ME, Han JC, Hon DN, Shantha B, Zhao B, SangJ, Zhang N, Sato R, Yoshii K, Panda-Jonas S, Ashley Koch AE, Herndon LW, Moroi SE, Challa P, Foo JN, Bei JX, Zeng YX, Simmons CP, Bich Chau TN, Sharmila PF, Chew M, Lim B, Tam PO, Chua E, Ng XY, Yong VH, Chong YF, Meah WY, Vijayan S, Seongsoo S, Xu W, Teo YY, Cooke Bailey JN, Kang JH, Haines JL, Cheng CY, Saw SM, Tai ES; ICAARE-Glaucoma Consortium; NEIGHBORHOOD Consortium, Richards JE, Ritch R, Gaasterland DE, Pasquale LR, Liu J, Jonas JB, Milea D, George R, Al-Obeidan SA, Mori K, Macgregor S, Hewitt AW, Girkin CA, Zhang M, Sundaresan P, Vijaya L, Mackey DA, Wong TY, Craig JE, Sun X, Kinoshita S, Wiggs JL, Khor CC, Yang Z, Pang CP, Wang N, Hauser MA, Tashiro K, Aung T, Vithana EN. A common variant near TGFBR3 is associated with primary open angle glaucoma. Hum Mol Genet. 2015 Apr 10.

  5. Narayanaswamy A, Leung CK, Istiantoro DV, Perera SA, Ho CL, Nongpiur ME, Baskaran M, Htoon HM, Wong TT, Goh D, Su DH, Belkin M, Aung T. Efficacy of selective laser trabeculoplasty in primary angle-closure glaucoma: a randomized clinical trial. JAMA Ophthalmol. 2015 Feb;133(2):206-12.

  6. Nongpiur ME, Haaland BA, Friedman DS, Perera SA, He M, Foo LL, Baskaran M, Sakata LM, Wong TY, Aung T. Classification Algorithms Based on Anterior Segment Optical Coherence Tomography Measurements for Detection of Angle Closure. Ophthalmology 2013; 120(1):48-54.

  7. Narayanaswamy AK, Zheng C, Perera SA, Htoon HM, Friedman DS, Tun TA, He M, Baskaran M, Aung T. Variations in Iris Volume with Physiological Mydriasis in Subtypes of Primary Angle Closure Glaucoma. Invest Ophthalmol Vis Sci 2013; 54: 708-13

  8. Zheng C, Guzman CP, Cheung CY, He Y, Friedman DS, Ong SH, Narayanaswamy AK, Chew PT, Perera SA, Aung T. Analysis of Anterior Segment Dynamics using Anterior Segment Optical Coherence Tomography Before and After Laser Peripheral Iridotomy. Arch Ophthalmol/JAMA Ophthalmol 2013; 131: 44-9.

  9. Vithana EN, Khor CC, Qiao C, Nongpiur ME, George R, Chen LJ, Do T, Abu-Amero K, Huang CK, Low S, Tajudin LS, Perera SA, Cheng CY, Xu L, Jia H, Ho CL, Sim KS, Wu R, Tham CC, Chew PT, Su DH, Oen FT, Sarangapani S, Soumittra N, Osman EA, Wong HT, Tang G, Fan S, Meng H, Huong DT, Wang H, Feng B, Baskaran M, Shantha B, Ramprasad VL, Kumaramanickavel G, Iyengar SK, How AC, Lee KY, Sivakumaran TA, Yong VHK, Ting SML, Li Y, Wang YX, Tay WT, Sim X, Lavanya R, Cornes BK, Zheng YF, Wong TT, Loon SC, Yong VK, Waseem N, Yaakub A, Chia KS, Allingham RR, Hauser MA, Lam DSC, Hibberd ML, Bhattacharya SS, Zhang M, Teo YY, Tan DT, Jonas JB, Tai ES, Saw SM, Hon DN, Al-Obeidan SA, Liu JJ, Bich Chau TN, Simmons CP, Bei JX, Zeng YX, Foster PJ, Vijaya L, Wong TY, Pang CP, Wang N, Aung T. Genome-wide association analyses identify three new susceptibility loci for Primary Angle Closure Glaucoma. Nat Genet 2012 Oct;44(10):1142-6. doi: 10.1038/ng.2390. Epub 2012 Aug 26.

  10. How AC, Baskaran M, Kumar RS, He MG, Foster PJ, Lavanya R, Wong HT, Chew PTK, Friedman DS, Aung T. Changes in anterior segment morphology after laser peripheral iridotomy: An anterior segment optical coherence tomography study. Ophthalmology 2012; 119: 1383-7.


Members

Research Team

Name

Designation

Prof Aung Tin

Senior Consultant, SNEC

Assoc Prof Shamira Perera

Senior Consultant, SNEC

Adj Assoc Prof Rahat Husain

Senior Consultant, SNEC

Adj Assoc Prof Ho Ching Lin

Senior Consultant, SNEC

Dr Boey Pui Yi

Consultant, SNEC

Dr Desmond Quek

Consultant, SNEC

Dr Alicia How

Consultant, SNEC

Dr Jocelyn Chua

Consultant, SNEC

Dr Daniel Su

Consultant, SNEC

Dr Michael Girard

Research Scientist

Prof Cheng Ching-Yu

Head, Ocular Epidemiology Research Group

Dr Baskaran Mani

Senior Clinical Research Fellow

Dr Monisha Esther Nongpiur

Senior Clinical Research Fellow

Dr Sushma Verma

Clinical Research Fellow, SERI

Tin Aung Tun Maung

Senior Research Associate


Research Optometrists/ Coordinators/ Assistants

Name

Designation

Serena Ting

Manager

Stella Ng

Senior Clinical Research Coordinator

Teo Soh Chin

Senior Clinical Research Coordinator

Ooi Ya Ying

Senior Clinical Research Coordinator

Anna Sim

Senior Clinical Research Coordinator

Fong Yee Wei

Senior Clinical Research Coordinator

Cheryl Tan

Senior Clinical Research Coordinator

​Serene Ku

Clinical Research Coordinator

​Sharon Soo

​Clinical Research Coordinator

​Janie Tay

​Senior Associate


Genetics Team

Name

Designation

Assoc Prof Eranga Vithana

Senior Principal Research Scientist

Dr Khor Chiea Chuen (GIS)

Research Scientist

Dr Lee Mei Chin

Senior Research Fellow

Dr Wu Meihui

Research Fellow

Victor Yong

Senior Research Officer

​Ng Xiao Yu

​Senior Research Officer

Chong Yaan Fun

Research Officer

Allan Li

Research Associate

           

Contact us

Prof Aung Tin at aung.tin@singhealth.com.sg