Skip Ribbon Commands
Skip to main content

Cornea & Refractive Research Group

Overview 

The Cornea and Refractive Research Group focuses on research relating to several aspects of corneal/refractive surgery. This includes understanding corneal wound healing following laser refractive surgery (i.e. using exicimer and femtosecond lasers, assessing the wound healing response following many refractive procedures, e.g. LASIK/SMILE/Presbyopia surgery).

The corneal research is mainly focused on developing techniques of selective cellular therapy such as corneal endothelial cell therapy and stromal cell therapy. The team works on developing and optimising culture protocols, and translating these therapies to preclinical animal models and clinical trials.


Projects

  1. Corneal endothelial cell therapy – investigating transportation of cells for clinical delivery, assessing the efficacy of cells for different delivery systems, QC of GMP modified cells, assessing the efficacy of different carrier systems for cell delivery, development of humanised s-PRDx6 for optimisation of cell delivery, development of culture systems for endothelial stem cells

  2. Stromal Cell therapy – optimisation of protocols for expansion of corneal keratocytes, assessing models of delivery of these cells, efficacy of the cells for stromal therapy

  3. Laser wound healing – wound healing responses following femtosecond laser corneal surgery for refractive and corneal transplantation, assessing wound healing following lenticule re-implantation, assessing lenticule integration

  4. Corneal gene therapy – assessing the effects of Cas 9 therapy patients with FECD, optimisation of vector delivery systems

  5. TGFBI dystrophies – understanding the pathological basis of TGFBI dystrophies, development of new drug based therapies for treatment

  6. Improvement outcomes in KPro design – surface coating to improve adhesion following KPro surgery, reducing infective rates following KPro Surgery

  7. Corneal transplantation – assessing clinical outcomes following corneal transplantation using cohort data from the SCTS


Publications

  1. Fuest M, Liu YC, Arundhati A, Li L, Tan D, Mehta JS. Long-term outcomes of hemi-automated lamellar keratoplasty. Clin Exp Ophthalmol. 2018 Jun 1. doi: 10.1111/ceo.13331. [Epub ahead of print]

  2. Han SB, Liu YC, Mohamed-Noriega K, Mehta JS. Application of Novel Drugs for Corneal Cell Regeneration. J Ophthalmol. 2018 May 2;2018:1215868. doi: 10.1155/2018/1215868. eCollection 2018. Review.

  3. Damgaard IB, Riau AK, Liu YC, Tey ML, Yam GH, Mehta JS. Reshaping and Customization of SMILE-Derived Biological Lenticules for Intrastromal Implantation. Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2555-2563. doi: 10.1167/iovs.17-23427.

  4. Ong HS, Chan AS, Yau CW, Mehta JS.Corneal Inlays for Presbyopia Explanted Due to Corneal Haze. J Refract Surg. 2018 May 1;34(5):357-360. doi: 10.3928/1081597X-20180308-01.

  5. Fuest M, Siregar SR, Farrag A, Htoon HM, Tan D, Mehta JS. Long-term follow-up of deep anterior lamellar keratoplasty after Descemet stripping automated endothelial keratoplasty.

  6. Graefes Arch Clin Exp Ophthalmol. 2018 May 8. doi: 10.1007/s00417-018-3997-6. [Epub ahead of print]

  7. Ang M, Baskaran M, Werkmeister RM, Chua J, Schmidl D, Aranha Dos Santos V, Garhöfer G, Mehta JS, Schmetterer L.Anterior segment optical coherence tomography. Prog Retin Eye Res. 2018 Apr 7. pii: S1350-9462(17)30085-X. doi: 10.1016/j.preteyeres.2018.04.002. [Epub ahead of print] Review.

  8. Liu YC, Wen J, Teo EPW, Williams GP, Lwin NC, Mehta JS.Higher-Order-Aberrations Following Hyperopia Treatment: Small Incision Lenticule Extraction, Laser-Assisted In Situ Keratomileusis and Lenticule Implantation. Transl Vis Sci Technol. 2018 Mar 29;7(2):15. doi: 10.1167/tvst.7.2.15. eCollection 2018 Apr.
    Williams GP, Wu B, Liu YC, Teo E, Nyein CL, Peh G, Tan DT, Mehta JS.Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model.
    PLoS One. 2018 Mar 28;13(3):e0194209. doi: 10.1371/journal.pone.0194209. eCollection 2018.

  9. Yam GH, Teo EP, Setiawan M, Lovatt MJ, Yusoff NZBM, Fuest M, Goh BT, Mehta JS. Postnatal periodontal ligament as a novel adult stem cell source for regenerative corneal cell therapy. J Cell Mol Med. 2018 Jun;22(6):3119-3132. doi: 10.1111/jcmm.13589. Epub 2018 Mar 13.

  10. Damgaard IB, Ang M, Farook M, Htoon HM, Mehta JS.Intraoperative Patient Experience and Postoperative Visual Quality After SMILE and LASIK in a Randomized, Paired-Eye, Controlled Study.

  11. J Refract Surg. 2018 Feb 1;34(2):92-99. doi: 10.3928/1081597X-20171218-01.

  12. Soh YQ, Mehta JS. Selective Endothelial Removal for Peters Anomaly. Cornea. 2018 Mar;37(3):382-385. doi: 10.1097/ICO.0000000000001472. Review.

  13. Liu YC, Ng XW, Teo EPW, Ang HP, Lwin NC, Chan NSW, Venkatraman SS, Wong TT, Mehta JS. A Biodegradable, Sustained-Released, Tacrolimus Microfilm Drug Delivery System for the Management of Allergic Conjunctivitis in a Mouse Model. Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):675-684. doi: 10.1167/iovs.17-23066.

  14. Soh YQ, Mehta JS. Regenerative Therapy for Fuchs Endothelial Corneal Dystrophy. Cornea. 2018 Apr;37(4):523-527. doi: 10.1097/ICO.0000000000001518.

  15. Liu YC, Teo EPW, Ang HP, Seah XY, Lwin NC, Yam GHF, Mehta JS. Biological corneal inlay for presbyopia derived from small incision lenticule extraction (SMILE). Sci Rep. 2018 Jan 30;8(1):1831. doi: 10.1038/s41598-018-20267-7.

  16. Soh YQ, Peh GS, Mehta JS. Evolving therapies for Fuchs' endothelial dystrophy. Regen Med. 2018 Jan;13(1):97-115. doi: 10.2217/rme-2017-0081. Epub 2018 Jan 23.

  17. Lovatt M, Yam GH, Peh GS, Colman A, Dunn NR, Mehta JS. Directed differentiation of periocular mesenchyme from human embryonic stem cells. Differentiation. 2018 Jan - Feb;99:62-69. doi: 10.1016/j.diff.2017.11.003. Epub 2017 Nov 16.

  18. Liu YC, Williams GP, George BL, Soh YQ, Seah XY, Peh GSL, Yam GHF, Mehta JS. Corneal lenticule storage before reimplantation. Mol Vis. 2017 Oct 27;23:753-764. eCollection 2017.


Members

Head

Assoc Prof Jodhbir Mehta


Team Members

  • Dr Gary Yam

  • Dr Gary Peh

  • Dr Matthew Lovatt

  • Dr Andri Riau

  • Dr Vidhya Venkataram

  • Ang Heng Peng

  • Seah Xin Yi

  • Khadijah Binte Adnan

  • Melina Setiawan

  • Gwendoline Goh

  • Ericia Teo


Contact us

Assoc Prof Jodhbir Mehta at jodhbir.s.mehta@singhealth.com.sg