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Cataract & Uveitis Research Group


The Cataract & Uveitis Research Group mainly focuses on clinician-initiated and industry-initiated studies. The aims are to conduct research focused on techniques, devices, equipment and intraocular lens implants that will culminate in peer-reviewed publications. 

Clinician-Initiated Studies

Clinician or surgeon initiated studies generally innovate from existing techniques, products, and instruments. They can also evaluate newer commercially available products used in surgery (femtosecond laser, new vs conventional). Studies have also been done to assess cataract patient outcomes in SNEC.

Industry-Initiated Studies

New products in different phases of trials are evaluated for safety and effectiveness. Such products usually include intraocular lens implants and phacoemulsification equipment. Industry-initiated studies include basic science studies, first in man studies and post-marketing studies.

This often involves the assessment of the relative benefits and risks of new devices, while spearheading research in the cataract arena. This allows for critical analysis of the efficacy of new intraocular devices, instrumentation and surgical equipment. Such focus provides further opportunity to develop systems, practices and instruments that are suitably designed to achieve good results for our Asian patients. 

Ongoing Projects


  1. Comparison of femtosecond laser assisted cataract surgery and conventional phacoemulsification surgery on dense cataracts

  2. Femtosecond laser in the management of subluxated cataracts

  3. Dropped nucleus following cataract surgery in SNEC


  1. A randomised clinical study to evaluate CALLISTO Eye 3.5 application by comparison of standard axis centration vs. CALLISTO Eye 3.5 guided centration in subject eyes indicated for standard toric cataract surgery

  2. A Prospective, Randomised, Controlled, First-In-Man Clinical Study for Vivinex® Gemetric® Diffractive Trifocal Toric IOL: MT2 in Cataract Patients


  1. Capsule milking: Modification of capsulorhexis technique for intumescent cataract. Chee SP, Chan NS. J Cataract Refract Surg. 2017 May;43(5):585-589. doi: 10.1016/j.jcrs.2017.04.023.

  2. Analysis of competency in phacoemulsification trainees using the cumulative sum analysis. Chan NS, Jap A, Yang Y, Tan SP, Chee SP. J Cataract Refract Surg. 2017 Mar;43(3):358-363. doi: 10.1016/j.jcrs.2016.12.026.

  3. Chee SP, Wong MH, Jap A. Management of Severely Subluxated Cataracts using Femtosecond Laser Assisted Cataract Surgery. Am J Ophthalmol. 2016 Sep 23. pii: S0002-9394(16)30476-7. doi: 10.1016/j.ajo.2016.09.021. [Epub ahead of print] PubMed PMID: 27670621.

  4. Optimizing Visual Outcomes of Cataract Surgery. Chee SP, Jap A. Asia Pac J Ophthalmol (Phila). 2015 Sep-Oct;4(5):243-4. doi:10.1097/APO.0000000000000144.

  5. Modified side-based scleral flap for intrascleral intraocular lens fixation. Chan NS, Jap A, Chee SP. J Cataract Refract Surg. 2015 Jul;41(7):1533-5. doi: 10.1016/j.jcrs.2015.04.028.

  6. Clinical Outcomes in the first 2 years of Femtosecond Laser-assisted Cataract Surgery. Chee SP, Yang Y, Ti SE. Am J Ophthalmol. 2015 Jan 26. pii: S0002-9394(15)00045-8. doi: 10.1016/j.ajo.2015.01.016. [Epub ahead of print]

  7. Endogenous Serratia marcescens endophthalmitis: an atypical presentation. Tan N1, Galvante PR2, Chee SP3. Eye (Lond). 2014 Jan;28(1):108-9. doi: 10.1038/eye.2013.237. Epub 2013 Nov 1.

  8. A 5-Year Audit of Cataract Surgery Outcomes After Posterior Capsule Rupture and Risk Factors Affecting Visual Acuity. Ti SE, Yang YN, Lang SS, Chee SP. Am J Ophthalmol. 2014 Jan;157(1):180-185.e1. doi: 10.1016/j.ajo.2013.08.022. Epub 2013 Oct 30.

  9. Improving presurgical pupil dilation for cataract surgery patients. Peng LH, Fong A,   Phaik CS, Hong TP, Hoon NS, Xuan CL, Yick K, Ng A. Jt Comm J Qual Patient Saf. 2012 Sep;38(9):419-25, 385.

  10. Cataract surgery in uveitis. Agrawal R, Murthy S, Ganesh SK, Phaik CS, Sangwan V, Biswas J. Int J Inflam. 2012;2012:548453. doi: 10.1155/2012/548453. Epub 2012 Feb 8.

  11. Risk factors for poor visual outcome following cataract surgery in Vogt-Koyanagi-Harada disease. Quek DT, Jap A, Chee SP. Br J Ophthalmol 2011 Nov;95(11):1542-6. Epub 2011 Feb 24

  12. Management of Traumatic Severely Subluxated Cataracts. Chee SP, Jap A. Am J Ophthalmol. 2011 May;151(5):866-871.e1. Epub 2011 Feb 18.

  13. Management of the Hard Posterior Polar Cataract. Chee SP. J Cataract Refract Surg. 2007 Sep; 33(9): 1509-14

  14. Brown discoloration of acrylic hydrophobic intraocular lens. Wong MHY, Su DH, Chee SP. Can J Ophthalmol. 2016 Aug;51(4):277-281. doi: 10.1016/j.jcjo.2016.02.007. Epub 2016 Jun 30. PubMed PMID: 27521667.

  15. Pseudo anterior capsule barrier for the management of posterior capsule rupture. Chee SP. J Cataract Refract Surg. 2012 Aug;38(8):1309-15. doi:10.1016/j.jcrs.2012.06.011. PubMed PMID: 22814036.

  16. Descemet membrane detachment after phacoemulsification surgery: risk factors and success of air bubble tamponade. Ti SE, Chee SP, Tan DT, Yang YN, Shuang SL. Cornea. 2013 Apr;32(4):454-9. doi: 10.1097/ICO.0b013e318254c045. PubMed PMID:22562063.

  17. Half-bow sliding knot: modified suture technique for scleral fixation using the corneoscleral pocket. Chee SP. J Cataract Refract Surg. 2011 Sep;37(9):1576-80. doi: 10.1016 /j.jcrs.2011.07.018. PubMed PMID: 21855757.

  18. Variation of cross-chop technique. Chee SP. J Cataract Refract Surg. 2010 Mar;36(3):530; author reply 530-1. doi: 10.1016/j.jcrs.2009.10.040. PubMed PMID: 20202568.

  19. Anterior segment optical coherence tomography evaluation of the integrity of clear corneal incisions: a comparison between 2.2-mm and 2.65-mm main incisions. Chee SP, Ti SE, Lim L, Chan AS, Jap A. Am J Ophthalmol. 2010 May;149(5):768-76.e1. doi: 10.1016 /j.ajo. 2009.12.008.  Epub 2010 Feb 26. PubMed PMID: 20189160.

  20. Anterior-assisted levitation for the posteriorly dislocated intraocular lens. Chee SP. J Cataract Refract Surg. 2009 Jun;35(6):980-6. doi:10.1016/j.jcrs.2009.01.030. PubMed PMID: 19465280.

  21. Management of the hard posterior polar cataract. Chee SP. J Cataract Refract

  22. Surg. 2007 Sep;33(9):1509-14. PubMed PMID: 17720063.

  23. Trisection technique: a 2-snip approach to intraocular lens explantation. Por YM, Chee SP. J Cataract Refract Surg. 2007 Jul;33(7):1151-4. PubMed PMID:17586369.

  24. Clear corneal incision leakage after phacoemulsification--detection using povidone iodine 5%. Chee SP. Int Ophthalmol. 2005 Aug-Oct;26(4-5):175-9. Epub 2007 Jan 26. PubMed PMID: 17253109.

  25. Modified technique for management of LIDRS. Bacsal K, Chee SP. J Cataract Refract Surg. 2007 Jan;33(1):4-5. PubMed PMID: 17189775.

  26. Posterior-assisted levitation: outcomes in the retrieval of nuclear fragments and subluxated intraocular lenses. Por YM, Chee SP. J Cataract Refract Surg. 2006 Dec;32(12):2060-3. PubMed PMID: 17137984.

  27. Modified technique for anterior chamber decompression for high intraocular pressure following phacoemulsification. Bacsal KE, Chee SP. J Cataract Refract Surg. 2006 Dec;32(12):1983; author reply 1983-4. PubMed PMID: 17137956.

  28. Implantation of foldable intraocular lens with anterior optic capture in isolated posterior capsule rupture. Por YM, Chee SP. J Cataract Refract Surg. 2006 May;32(5):707-8. PubMed PMID: 16765774.

  29. Endophthalmitis after microincision cataract surgery. Chee SP, Bacsal K. J Cataract Refract Surg. 2005 Sep;31(9):1834-5. PubMed PMID: 16246795.

  30. Surodex after phacoemulsification. Lee SY, Chee SP. J Cataract Refract Surg. 2005 Aug;31(8):1479-80. PubMed PMID: 16129266.

  31. Management of lens-iris diaphragm retropulsion syndrome. Chee SP, Bacsal K. J Cataract Refract Surg. 2005 Jul;31(7):1272-3; author reply 1273. PubMed PMID:16105583

  32. Spontaneous disinsertion of a multipiece foldable acrylic intraocular lens haptic 3 and 12 months after implantation. Por YM, Chee SP. J Cataract Refract Surg. 2004 May;30(5):1139-42. PubMed PMID: 15130659.

  33. The epidemiology of acute endophthalmitis after cataract surgery in an Asian population. Wong TY, Chee SP. Ophthalmology. 2004 Apr;111(4):699-705. PubMed PMID: 15051201.



Prof Chee Soon Phaik

Team Members

  • Dr Ti Seng Ei

  • Clin Assoc Prof Ronald Yeoh