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Retina Research Group


Overview

The SERI Retina group comprises of clinicians, clinician-scientists and scientists with a broad focus and expertise in basic, translational and clinical research in characterizing molecular mechanisms and pathways, epidemiology, imaging and management of retinal disorders. Particularly, the group emphasises Asian Age-related Macular Degeneration (AMD), including polypoidal choroidal vasculopathy (PCV), diabetic retinopathy (DR) and other retinal disorders, such as central serous chorioretinopathy (CSR).


Strengths

  • Clinical expertise in management of Asian retinal diseases

  • Clinical cohorts of  >2,000 patients with AMD and DR

  • Epidemiological and genetic database on >10,000 patients

  • State-of-the-art animal facility with animal models for retinal diseases

  • World-class Retinal Imaging & Ocular Grading Centre

  • SIPRAD – An industry standard platform in retinal angiogenic diseases


Projects

Selected Projects

1. Does Genetic Variation in the CFH region of age-related macular degeneration patients allow bacteria to trigger the disease?

Prof Wong Tien Yin

2. Singapore Diabetic Retinopathy Epidemiology, Biomarkers and Imaging (DREAM) Program

Prof Wong Tien Yin

3. Phenotyping Asian Macular Diseases – a prospective functional and angiographic study of the clinical course of three common acquired retinal conditions in an Asian population

Assoc  Prof Gemmy Cheung

4. Detailed choroidal sub-layer analysis of age-related macular degeneration.

Assoc Prof Yasuo Yanagi

5. Pathophysiology of diabetic retinopathy and novel drugs for diabetic retinopathy using DR mouse model

Dr Velachamy A Barathi

6. Screening of novel drugs in laser-induced CNV model in rodents and non-human primates

Dr Velachamy A Barathi & Assoc Prof Gemmy Cheung

7. Genome- Wide Association Studies on Diabetic Retinopathy in Asians

Dr Gavin Tan

8. Ocular Biomarker Study for Retinal Angiogenic Diseases (OBSRAD study)

PI: Assoc Prof Gemmy Cheung; Co-I: Dr Danny Cheung

 9. Investigation of LGR5 as a bonafide retinal stem cell marker

PI: Dr Shweta Singhal

10. Investigation into the use of Dental Pulp Stem Cells (DPSC) as a source of retinal stem cells

PI: Dr Shweta Singhal; Co-I: Dr Gary Yam & Dr Goh Bee Tin (NDC)


Publications

    1. Cheung CMG, Laude A, et al. Improved specificity of polypoidal choroidal vasculopathy diagnosis using a modified EVEREST criteria. Retina 2014 (in press)

    2. Wong CW, Cheung CM, Mathur R, et al. Three year results of polypoidal choroidal vasculopathy treated with photodynamic therapy: retrospective study and systematic review. Retina 2014 (in press)

    3. Lim LS, Ling LH, …Cheung CMG, Wong TY. Dynamic responses in retinal vessel caliber with flicker light stimulation in eyes with diabetic retinopathy. Invest Ophthalmol Vis Sci 2014;55:5207.

    4. Joachim N, Mitchell P, … Cheung GC, et al. Ethnic Variation in Early Age-related macular degeneration lesions between white Australians and Singaporean Asians. Invest Ophthalmol Vis Sci 2014;55:442

    5. Cheung CMG, Lai TYY, Cheng SJ, et al. Understanding indocyanine green angiography in polypoidal choroidal vasculopathy: The group experience with digital fundus photography and confocal scanning laser ophthalmoscopy. Retina2104. Epub ahead of print.

    6. Cheung CMG, Li X, Cheng CY, et al. Prevalence, racial variations and risk factors of age-related macular degeneration in Singaporean Chinese, Indians and Malays. Ophthalmology 2014;121:1598.

    7. Wong WL, Su X, Li X, Cheung CMG et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: A systematic review and meta-analysis. Lancet Glob Health 2014;2.

    8. Cheung CMG, Li X, Mathur R, et al. A prospective study of treatment patterns and 1-year outcome of Asian Age-related macular degeneration and polypoidal choroidal vasculopathy. Plos One 2014 Jun 30;9(6):e101057.

    9. Cheung CM, Wong TY. Treatment of age-related macular degeneration. Lancet2013;S0140-6736(13)61580.

    10. Chang L, Pan CW, Ohno-Matsui K, Lin X, Cheung GC, et al. Myopia-Related Fundus Changes in Singapore Adults With High Myopia. Am J Ophthalmol.2013;155:991-999.

    11. Pan CW, Ikram K, Cheung CY, Choi HW, Cheung CM, Jonas JB, Saw SM, Wong TY. Refractive errors and age-related macular degeneration: a systematic review and meta-analysis. Ophthalmology 2013;120:2058-65.

    12. Cheung N, Tay WT, Cheung CM, Wang JJ, Mitchell P, Wong TY. Is Aspirin intake associated with early age-related macular degeneration? The Singapore Indian Eye Study. Br J Ophthalmol 2013;97(6): 785-8.

    13. Cheung CMG, Loh BK, Li X, Mathur R, et al. Choroidal thickness and risk characteristics of eyes with myopic choroidal neovascularisation. Acta Ophthalmol 2013; 91(7): e580–e581.

    14. Lim LS, Cheung CM, Wong TY. Asian Age-related Macular degeneration: current concepts and gaps in knowledge. Asia-pacific J Ophthalmol 2013; 2(1): 32-41.

    15. Pan CW, Cheung CY, Aung T, Cheung CM, et al. Differential associations of myopia with major age-related eye diseases: The Singapore Indian Eye Study. Ophthalmology 2013; 120(2):284-91.

    16. Cheung CMG, Li X, Cheng CY, et al. Prevalence and risk factors for age-related macular degeneration in Indians: A comparative study in Singapore and India. Am J Ophthalmol 2013;155(4):764-73.

    17. Cheung CM, Yeo I, Li X, Mathur R, et al. Argon Laser with and without Anti-Vascular Endothelial Growth Factor Therapy for Extrafoveal Polypoidal Choroidal Vasculopathy. Am J Ophthalmol 2013;155(2):295-304.

    18. Neelam K, Cheung CM, Ohno-Matsui K, Lai TY, Wong TY. Choroidal neovascularization in pathological myopia. Pro Retin Eye Res. 2012 Sep;31(5):495-525.

    19. Cheung CM, Vania M, Ang M, Li J, Chee SP. Comparison of Aqueous Cytokine and Chemokine levels in diabetic patients with and without retinopathy. Mol Vis.2012; 18:830-7.

    20. Cheung CM, Bhargava M, Laude A, Koh ACH, Li X, Wong D, Niang T, Lim TH, Gopal L, Wong TY. Asian Age-related Macular Degeneration Phenotyping Study: Rationale, Design and Protocol of a Prospective Cohort study. Clin Exp Ophthalmol. 2012;40(7):727-35.

    21. Koh V, Cheung CY, Wong WL, Cheung GCM, Want JJ, Mitchell P, Younan C, Saw SM, Wong TY. Prevalence and Risk factors of epiretinal membrane in Asian Indians. Invest Ophthalmol Vis Sci 2012; 53:1018-22.

    22. Cheung CM, Wong TY. Anti-VEGF Debate: Limitation in Asia. New Eng J Med2011;365:2237.

    23. Cheung CM, Tai ES, Kawasaki R, Tay WT, Lee JL, Hamzah H, Wong TY. Prevalence of and risk factors for age-related macular degeneration in a multiethnic Asian cohort. Arch Ophthalmol 2012;130(4):480-6.

    24. Lim LS, Cheung CM, Mitchell P, Wong TY. Emerging evidence concerning systemic safety of anti-VEGF agents-should ophthalmologists be concerned? Am J Ophthalmol 2011;152:329-31.

    25. Cheung CM, Cheung CY, Yang EL, Mitchell P, Wang JJ, Wong TY. Retinal Arteriolar Wall Signs and Early Age-Related Macular Degeneration: The Singapore Malay Eye Study. Am J Ophthalmol 2011; 152: 108-113.

    26. Cackett P, Yeo I, Cheung CM, Vithana EN, Wong D, Tay WT, Tai ES, Aung T, Wong TY. Relationship of Smoking and Cardiovascular Risk Factors with Polypoidal Choroidal Vasculopathy and Age-Related Macular Degeneration in Chinese Persons. Ophthalmology 2011; 118:846-52.

    27. Lamoureux EL, Mitchell P, Rees G, Cheung G, Yeo I, Lee SY, Liu E, Wong TY. Impact of early and late age-related macular degeneration on vision-specific function. Br J Ophthalmol 2011; 95: 666-70.


        Members

        Head:
        Assoc Prof Gemmy Cheung, Head & Senior Consultant


        SNEC/SERI Clinical Team:

        1. Prof Wong Tien Yin, Senior Principal Clinician Scientist

        2. Assoc Prof Gemmy Cheung, Head & Senior Consultant

        3. Dr Doric Wong, Head & Senior Consultant

        4. Assoc Prof Ian Yeo, Senior Consultant

        5. Dr Edmund Wong, Deputy Medical Director & Senior Consultant

        6. Adj Assoc Prof Lee Shu Yen, Senior Consultant

        7. Dr Ranjana Sanjay Mathur, Senior Consultant

        8. Dr Chan Choi Mun, Senior Consultant

        9. Dr Gavin Tan, Consultant

        10. Assoc Prof Yasuo Yanagi, Clinician Scientist

        11. Dr Danny Cheung, Clinical Vitreoretinal Fellow

        12. Dr Anna Tan, Consultant

        13. Dr Shweta Singhal, Clinician Scientist


        SERI Research Team:

        1. Dr V A Barathi, Head, Translational Pre-Clinical Model Platform

        2. Prof Cheng Ching-Yu, Principal Clinician Scientist and Head of Ocular Epidemiology Research Group and Data Science Unit

        3. Prof Ecosse Lamoureux, Director, Population Health and Principal Research Scientist

        4. Assoc Prof Charumathi Sabanayagam, Clinician Scientist, Deputy Head, Ocular Epidemiology Research Group

        5. Dr Carol Cheung, Adjunct Research Scientist


        Contact us
        :

        Assoc Prof Gemmy Cheung at gemmy.cheung.c.m@singhealth.com.sg