The Cataract & Refractive Surgery Research Group mainly focuses on clinician-initiated and industry-initiated studies. The aims are to conduct research focused on techniques, devices, equipment and intraocular lens implants that will culminate in peer-reviewed publications.
Clinician-Initiated Studies
Clinician or surgeon-initiated studies generally innovate from existing techniques, products, and instruments. They can also evaluate newer commercially available products used in surgery (femtosecond laser, new vs conventional). Studies have also been done to assess cataract patient outcomes in SNEC.
Industry-Initiated Studies
New products in different phases of trials are evaluated for safety and effectiveness. Such products usually include intraocular lens implants and phacoemulsification equipment. Industry-initiated studies include basic science studies, first-in-man studies and post-marketing studies.
This often involves the assessment of the relative benefits and risks of new devices, while spearheading research in the cataract arena. This allows for critical analysis of the efficacy of new intraocular devices, instrumentation and surgical equipment. Such focus provides further opportunity to develop systems, practices and instruments that are suitably designed to achieve good results for our Asian patients.
Clinician-Initiated
Biometry measurement trends and comparisons, and formulae prediction accuracy in Singapore
Dropped nucleus following cataract surgery in SNEC
Multiomics approach to define immune response in cytomegalovirus uveitis
Using metagenomics next generation sequencing (NGS) for improving the diagnosis of infectious uveitis
Case series of eyes with subluxated Intraocular lens due to late spontaneous posterior capsule rupture
Singapore Viral Uveitis Study
Demographics and clinical characteristics of ocular inflammatory diseases in Singapore
International vitreoretinal B-cell lymphoma registry
Industry-Initiated
A prospective, randomised, controlled, first-in-man clinical study for Vivinex® Gemetric® Diffractive Trifocal Toric IOL: MT2 in cataract patients
A comparative clinical evaluation of new TECNIS® presbyopia-correcting intraocular lens against a trifocal intraocular lens
Jabs DA, Acharya NR, Chee SP, Goldstein D, McCluskey P, Murray PI, Oden N, Palestine AG, Rosenbaum JT, Thorne JE, Trusko BE. Classification criteria for juvenile idiopathic arthritis-associated chronic anterior uveitis. Am J Ophthalmol. 2021 Apr 9:S0002-9394(21)00180-X. doi: 10.1016/j.ajo.2021.03.055. Epub ahead of print. PMID: 33845021.
Jabs DA, Caspers L, Chee SP, Galor A, Goldstein D, McCluskey P, Murray PI, Oden N, Palestine AG, Rosenbaum JT, Thorne JE, Trusko BE; Standardization of Uveitis Nomenclature (SUN) Working Group. Classification criteria for cytomegalovirus anterior uveitis. Am J Ophthalmol. 2021 Apr 9:S0002-9394(21)00185-9. doi: 10.1016/j.ajo.2021.03.060. Epub ahead of print. PMID: 33845019.
Jabs DA, Acharya NR, Caspers L, Chee SP, Goldstein D, McCluskey P, Murray PI, Oden N, Palestine AG, Rosenbaum JT, Thorne JE, Trusko BE; Standardization of Uveitis Nomenclature (SUN) Working Group. Classification criteria for varicella zoster virus anterior uveitis. Am J Ophthalmol. 2021 Apr 9:S0002-9394(21)00162-8. doi: 10.1016/j.ajo.2021.03.037. Epub ahead of print. PMID: 33845010.
Jabs DA, Acharya NR, Caspers L, Chee SP, Goldstein D, McCluskey P, Murray PI, Oden N, Palestine AG, Rosenbaum JT, Thorne JE, Trusko BE. Classification criteria for herpes simplex virus anterior uveitis. Am J Ophthalmol. 2021 Apr 9:S0002-9394(21)00178-1. doi: 10.1016/j.ajo.2021.03.053. Epub ahead of print. PMID: 33845009.
Working Group TSOUNS, Jabs DA, Acharya NR, Chee SP, Goldstein D, McCluskey P, Murray PI, Oden N, Palestine AG, Rosenbaum JT, Thorne JE, Trusko BE. Classification criteria for Fuchs uveitis syndrome. Am J Ophthalmol. 2021 Apr 9:S0002-9394(21)00177-X. doi: 10.1016/j.ajo.2021.03.052. Epub ahead of print. PMID: 33845007.
Standardization of Uveitis Nomenclature (SUN) Working Group, Jabs DA, Acharya NR, Chee SP, Goldstein D, McCluskey P, Murray PI, Oden N, Palestine AG, Rosenbaum JT, Thorne JE, Trusko BE. Classification criteria for spondyloarthritis/HLA-B27-associated anterior uveitis. Am J Ophthalmol. 2021 Apr 9:S0002-9394(21)00174-4. doi: 10.1016/j.ajo.2021.03.049. Epub ahead of print. PMID: 33845004.
Chan NS, Chee SP. Keratic Precipitates: The Underutilized Diagnostic Clue. Ocul Immunol Inflamm. 2021 Apr 7:1-10. doi: 10.1080/09273948.2020.1836236. Epub ahead of print. PMID: 33826455.
Yawata N, Shirane M, Woon K, Lim X, Tanaka H, Kawano YI, Yawata M, Chee SP, Siak J, Sonoda KH. Molecular Signatures of Natural Killer Cells in CMV-Associated Anterior Uveitis, A New Type of CMV-Induced Disease in Immunocompetent Individuals. Int J Mol Sci. 2021 Mar 31;22(7):3623. doi: 10.3390/ijms22073623. PMID: 33807229; PMCID: PMC8037729.
Chee SP, Yang Y, Wong MH. Randomised Controlled Trial comparing Femtosecond Laser-Assisted and Conventional Phacoemulsification on Dense Cataracts. Am J Ophthalmol. 2021 Mar 1:S0002-9394(20)30682-6. doi: 10.1016/j.ajo.2020.12.024. Epub ahead of print. PMID: 33662301.
Yonova-Doing E, Zhao W, Igo RP Jr, Wang C, Sundaresan P, Lee KE, Jun GR, Alves AC, Chai X, Chan ASY, Lee MC, Fong A, Tan AG, Khor CC, Chew EY, Hysi PG, Fan Q, Chua J, Chung J, Liao J, Colijn JM, Burdon KP, Fritsche LG, Swift MK, Hilmy MH, Chee ML, Tedja M, Bonnemaijer PWM, Gupta P, Tan QS, Li Z, Vithana EN, Ravindran RD, Chee SP, Shi Y, Liu W, Su X, Sim X, Shen Y, Wang YX, Li H, Tham YC, Teo YY, Aung T, Small KS, Mitchell P, Jonas JB, Wong TY, Fletcher AE, Klaver CCW, Klein BEK, Wang JJ, Iyengar SK, Hammond CJ, Cheng CY. Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract. Commun Biol. 2020 Dec 11;3(1):755. doi: 10.1038/s42003-020-01421-2. PMID: 33311586; PMCID: PMC7733496.
Ei Ei Lin Oo, Chee SP, Wong KKY, Hla Myint Htoon. Vogt-Koyanagi-Harada Disease Managed With Immunomodulatory Therapy Within 3 Months of Disease Onset. Am J Ophthalmol. 2020 Dec;220:37-44. doi: 10.1016/j.ajo.2020.07.036. Epub 2020 Jul 30. PMID: 32738228.
Agrawal R, Testi I, Bodaghi B, Barisani-Asenbauer T, McCluskey P, Agarwal A, Kempen JH, Gupta A, Smith JR, de Smet MD, Yuen YS, Mahajan S, Kon OM, Nguyen QD, Pavesio C, Gupta V; Collaborative Ocular Tuberculosis Study Consensus Group. Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis-Report 2: Guidelines for Initiating Antitubercular Therapy in Anterior Uveitis, Intermediate Uveitis, Panuveitis, and Retinal Vasculitis. Ophthalmology. 2021 Feb;128(2):277-287. doi: 10.1016/j.ophtha.2020.06.052. Epub 2020 Jun 27. PMID: 32603726.
Agrawal R, Testi I, Mahajan S, Yuen YS, Agarwal A, Kon OM, Barisani-Asenbauer T, Kempen JH, Gupta A, Jabs DA, Smith JR, Nguyen QD, Pavesio C, Gupta V; Collaborative Ocular Tuberculosis Study Consensus Group. Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis-Report 1: Guidelines for Initiating Antitubercular Therapy in Tubercular Choroiditis. Ophthalmology. 2021 Feb;128(2):266-276. doi: 10.1016/j.ophtha.2020.01.008. Epub 2020 Jan 11. PMID: 32115264.
Daya S, Chee SP, Ti SE, Packard R, Mordaunt DH. Comparison of anterior capsulotomy techniques: continuous curvilinear capsulorhexis, femtosecond laser-assisted capsulotomy and selective laser capsulotomy. Br J Ophthalmol. 2020 Mar;104(3):437-442. doi: 10.1136/bjophthalmol-2018-313421. Epub 2019 Apr 4. PMID: 30948356.
Daya SM, Chee SP, Ti SE, Packard R, Mordaunt DH. Parameters affecting anterior capsulotomy tear strength and distension. J Cataract Refract Surg. 2019 Mar;45(3):355-360. doi: 10.1016/j.jcrs.2018.09.027. Epub 2018 Nov 30. PMID: 30509745.
Chan NS, Chee SP. Demystifying viral anterior uveitis: a review. Clin Exp Ophthalmol. 2018 Oct 21. doi: 10.1111/ceo.13417. [Epub ahead of print] Review. PubMed PMID: 30345620.
Chee SP, Chan NS, Yang Y, Ti SE. Femtosecond laser-assisted cataract surgery for the white cataract. Br J Ophthalmol. 2018 Jun 15. pii: bjophthalmol-2018-312289. doi: 10.1136/bjophthalmol-2018-312289. [Epub ahead of print] PubMed PMID: 29907631.
Chee SP, Chan NS. Suture snare technique for scleral fixation of intraocular lenses and capsular tension devices. Br J Ophthalmol. 2018 Jun 11. pii: bjophthalmol-2018-311868. doi: 10.1136/bjophthalmol-2018-311868. [Epub ahead of print] PubMed PMID: 29891735.
Dick AD, Rosenbaum JT, Al-Dhibi HA, Belfort R Jr, Brézin AP, Chee SP, Davis JL, Ramanan AV, Sonoda KH, Carreño E, Nascimento H, Salah S, Salek S, Siak J, Steeples L; Fundamentals of Care for Uveitis International Consensus Group. Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis: Fundamentals Of Care for UveitiS (FOCUS) Initiative. Ophthalmology. 2018 May;125(5):757-773. doi: 10.1016/j.ophtha.2017.11.017. Epub 2018 Jan 6. PMID: 29310963.
Chee SP, Chan NS. Capsule milking: Modification of capsulorhexis technique for intumescent cataract. J Cataract Refract Surg. 2017 May;43(5):585-589. doi: 10.1016/j.jcrs.2017.04.023.
Wakefield D, McCluskey P, Wildner G, Thurau S, Carr G, Chee SP, Forrester J, Dick A, Hudson B, Lightman S, Smith J, Tugal-Tutkun I; pre-treatment assessment Review panel. Inflammatory eye disease: Pre-treatment assessment of patients prior to commencing immunosuppressive and biologic therapy: Recommendations from an expert committee. Autoimmun Rev. 2017 Mar;16(3):213-222. doi: 10.1016/j.autrev.2017.01.003. Epub 2017 Jan 27. PMID: 28137477.
Carr JM, Ashander LM, Calvert JK, Ma Y, Aloia A, Bracho GG, Chee SP, Appukuttan B, Smith JR. Molecular Responses of Human Retinal Cells to Infection with Dengue Virus. Mediators Inflamm. 2017;2017:3164375. doi: 10.1155/2017/3164375. Epub 2017 Nov 12. Erratum in: Mediators Inflamm. 2018 Dec 23;2018:9891049. PMID: 29515292; PMCID: PMC5829438.
Chee SP, Wong MH, Jap A. Management of Severely Subluxated Cataracts using Femtosecond Laser Assisted Cataract Surgery. Am J Ophthalmol. 2016 Sep 23. pii: S0002-9394(16)30476-7. doi: 10.1016/j.ajo.2016.09.021. [Epub ahead of print] PubMed PMID: 27670621.
Jap A, Chee SP. The role of enhanced depth imaging optical coherence tomography in chronic Vogt-Koyanagi-Harada disease. Br J Ophthalmol. 2017 Feb;101(2):186-189. doi: 10.1136/bjophthalmol-2015-308091. Epub 2016 Apr 5. PMID: 27048179.
Chee SP, Yang Y, Ti SE. Clinical outcomes in the first two years of femtosecond laser-assisted cataract surgery. Am J Ophthalmol. 2015 Apr;159(4):714-9. doi: 10.1016/j.ajo.2015.01.016. Epub 2015 Jan 26. PMID: 25634531.
Quek DT, Jap A, Chee SP. Risk factors for poor visual outcome following cataract surgery in Vogt-Koyanagi-Harada disease. Br J Ophthalmol. 2011 Nov;95(11):1542-6. doi: 10.1136/bjo.2010.184796. Epub 2011 Feb 24. PMID: 21349937.
Chee SP, Jap A. Management of traumatic severely subluxated cataracts. Am J Ophthalmol. 2011 May;151(5):866-871.e1. doi: 10.1016/j.ajo.2010.10.035. Epub 2011 Feb 18. PMID: 21310378.
Ti SE, Yang YN, Lang SS, Chee SP. A 5-year audit of cataract surgery outcomes after posterior capsule rupture and risk factors affecting visual acuity. Am J Ophthalmol. 2014 Jan;157(1):180-185.e1. doi: 10.1016/j.ajo.2013.08.022. Epub 2013 Oct 30. PMID: 24182746.
Chee SP, Jap A. The outcomes of indocyanine green angiography monitored immunotherapy in Vogt-Koyanagi-Harada disease. Br J Ophthalmol. 2013 Feb;97(2):130-3. doi: 10.1136/bjophthalmol-2012-302538. Epub 2012 Dec 4. PMID: 23212203.
Cheung CM, Chee SP. Posterior scleritis in children: clinical features and treatment. Ophthalmology. 2012 Jan;119(1):59-65. doi: 10.1016/j.ophtha.2011.09.030. Epub 2011 Dec 3. PMID: 22137553.
Ang M, Hedayatfar A, Wong W, Chee SP. Duration of anti-tubercular therapy in uveitis associated with latent tuberculosis: a case-control study. Br J Ophthalmol. 2012 Mar;96(3):332-6. doi: 10.1136/bjophthalmol-2011-300209. Epub 2011 Jun 30. PMID: 21719564.
Ang M, Jap A, Chee SP. Prognostic factors and outcomes in endogenous Klebsiella pneumoniae endophthalmitis. Am J Ophthalmol. 2011 Feb;151(2):338-44.e2. doi: 10.1016/j.ajo.2010.08.036. Epub 2010 Dec 18. PMID: 21168820.
Ang M, Htoon HM, Chee SP. Diagnosis of tuberculous uveitis: clinical application of an interferon-gamma release assay. Ophthalmology. 2009 Jul;116(7):1391-6. doi: 10.1016/j.ophtha.2009.02.005. PMID: 19576501.
Chee SP, Jap A. Presumed fuchs heterochromic iridocyclitis and Posner-Schlossman syndrome: comparison of cytomegalovirus-positive and negative eyes. Am J Ophthalmol. 2008 Dec;146(6):883-9.e1. doi: 10.1016/j.ajo.2008.09.001. PMID: 19027423.
Chee SP, Jap A, Cheung CM. The prognostic value of angiography in Vogt-Koyanagi-Harada disease. Am J Ophthalmol. 2010 Dec;150(6):888-93. doi: 10.1016/j.ajo.2010.06.029. Epub 2010 Oct 8. PMID: 20933219.
Chee SP, Bacsal K, Jap A, Se-Thoe SY, Cheng CL, Tan BH. Clinical features of cytomegalovirus anterior uveitis in immunocompetent patients. Am J Ophthalmol. 2008 May;145(5):834-40. doi: 10.1016/j.ajo.2007.12.015. Epub 2008 Feb 6. PMID: 18255045.
Bacsal K, Wen DS, Chee SP. Concomitant choroidal inflammation during anterior segment recurrence in Vogt-Koyanagi-Harada disease. Am J Ophthalmol. 2008 Mar;145(3):480-486. doi: 10.1016/j.ajo.2007.10.012. Epub 2008 Jan 11. PMID: 18191100.
Su DH, Bacsal K, Chee SP, Flores JV, Lim WK, Cheng BC, Jap AH; Dengue Maculopathy Study Group. Prevalence of dengue maculopathy in patients hospitalized for dengue fever. Ophthalmology. 2007 Sep;114(9):1743-7. doi: 10.1016/j.ophtha.2007.03.054. Epub 2007 Jun 11. PMID: 17561258.
Bacsal KE, Chee SP, Cheng CL, Flores JV. Dengue-associated maculopathy. Arch Ophthalmol. 2007 Apr;125(4):501-10. doi: 10.1001/archopht.125.4.501. PMID: 17420370.
Chee SP, Bacsal K, Jap A, Se-Thoe SY, Cheng CL, Tan BH. Corneal endotheliitis associated with evidence of cytomegalovirus infection. Ophthalmology. 2007 Apr;114(4):798-803. doi: 10.1016/j.ophtha.2006.07.057. Epub 2007 Jan 3. PMID: 17207531.
Chia A, Luu CD, Mathur R, Cheng B, Chee SP. Electrophysiological findings in patients with dengue-related maculopathy. Arch Ophthalmol. 2006 Oct;124(10):1421-6. doi: 10.1001/archopht.124.10.1421. PMID: 17030709.
Lim WK, Mathur R, Koh A, Yeoh R, Chee SP. Ocular manifestations of dengue fever. Ophthalmology. 2004 Nov;111(11):2057-64. doi: 10.1016/j.ophtha.2004.03.038. PMID: 15522372.
Co-Heads
Prof Jod Mehta
Assoc Prof Shamira Perera
Team Members
Dr Ti Seng Ei
Clin Assoc Prof Ronald Yeoh
Dr Jay Siak Jyh Kuen
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