Grants FY21-22

NMRC

• “Retinal Microvascular Changes in Pre-diabetes: Predicting the Progression to Diabetes and Evaluating the Response to Exercise. The Pre-DICTED EYE Study”
  Assoc Prof Gavin Tan; S$1,046,472.00

• “Revisiting the Structure/Function Relationship in Glaucoma for Improved Patient Care”
  Prof Leopold Schmetterer; S$1,249,913.00
  • “Developing Hyperspectral OCT as a Clinical Test to Detect Neural Dysfunction in Degenerative Diseases of the Optic Nerve and Retina”
  Prof Leopold Schmetterer; S$5,656,864.95

• “Personalizing Diabetic Retinopathy Screening Intervals via Risk Stratification using an Artificial Intelligence-enabled Multi-modal Machine Learning Approach”
  Assoc Prof Daniel Ting; S$674,995.00

• “Comparison of Focal Inner and Outer Retina Structure and Function to Accurately Diagnose Glaucoma in High Myopia Eyes”
  Dr Rachel Chong; S$312,000.00

• “SAMURAI (Singapore Advanced Multi-subspeciality Unified Research and Innovation Centre in Ophthalmology)”
  Prof Aung Ting, S$20,000,000.00

• “Healthy living through personalized monitoring of eyelid care”
  Prof Louis Tong; S$58,000.00

• “Novel AI-driven ageing biomarker based on retinal photos for mortality risk stratification”
  Prof Cheng Ching-Yu; S$58,000.00

• “Modulatory effects of mesenchymal stem cells-derived extracellular vesicles on conjunctival innate immune responses to viral infections”
  Dr Ong Hon Shing; S$200,000.00

• “Studying neurorecovery of retinal ganglion cells in ageing after glaucomatous injury”
  Dr Katharina Bell; S$199,870.00

• “An Intensive, Practical, and Personalized Care Planning to Improve Glycemic Control, Clinical, Ocular, And Patient Centred Outcomes in Poorly Controlled Patients with Diabetic Retinopathy”
  Prof Ecosse Lamoureux; S$43,323.00

• “Optimising the assessment of quality of life in glaucoma using item bank and computer adaptive testing systems”
  Prof Ecosse Lamoureux; S$75,000.00

• “Translational program in ocular surface and dry eye”
  Prof Louis Tong; S$62,957.53

• “Investigating the Genetic and Phenotypic Architecture of Advanced Primary Angle Closure Glaucoma for Stratified Disease management”
  Dr Monisha Nongpiur; S$75,000.00

• “An Innovative and Patient-Centric Research Program Targeting the Ageing Singaporeans: The PopulatION HEalth and Eye Disease PRofile in Elderly Singaporeans (PIONEER) Study”
  Prof Ecosse Lamoureux; S$100,000.00

• “Harnessing LOXL1 as a therapeutic candidate for exfoliation syndrome and exfoliation glaucoma”
  Prof Aung Tin; S$100,000.00

• “The Singapore Epidemiology of Eye Diseases (SEED) Study 3 – Prospective multi-ethnic cohort study of 12-year incidence, risk factors, and impact of major age-related eye diseases”
  Prof Cheng Ching-Yu; S$99,716.00

• “Investigating the role of the primary angle closure glaucoma (PACG) susceptibility gene, PLEKHA7 in PLEKHA7-/- mutant rats”
  Dr Anita Chan; S$75,000.00

• “Scleral Biomechanical Properties in Pathologic Myopia and Myopic Glaucoma”
  Dr Donny Hoang; S$75,000.00

• “Targeted Cell-Based Therapeutic Program for Corneal Blindness”
  Prof Jodhbir Mehta; S$100,000.00

• “Optimising Surgical Management and Patient-related Outcomes of Epiretinal Membrane: Predictive Analytics and Randomised Trial”
  Dr Cheung Ning; S$75,000.00

• “Improved Detection of Glaucomatous Structural Damage Using Wide-Field Optical Coherence Tomography”
  Dr Jacqueline Chua; S$50,000.00

• “Singapore Angle Closure Glaucoma Program: From Genetics to Precision Medicine and Therapy”
  Prof Aung Tin; S$180,966.00

• “Using Novel imaging biomarkers to predict Vascular Endothelial Growth Factor inhibitor retreatment load for neovascular Age related Macular Degeneration”
  Dr Kelvin Teo; S$50,000.00

• “Community-based Screening for Pathological Visual Impairment among Elderly Residents using Artificial-Intelligence Integrated Retinal Imaging”
  Dr Tham Yih Chung; S$50,000.00

• “Development and Validation of a Myopia-Specific Item Bank Administered using Computerized Adaptive Testing: The MyoCAT Study”
  Dr Ryan Man; S$50,000.00

• “TAAP: Translational Asian Age-related Macular Degeneration Program”
  Prof Gemmy Cheung; S$300,000.00

• “A study to identify markers of early retinal cell fate commitment in pluripotent stem cells in vitro”
  Dr Shweta Singhal; S$50,000.00

• “Bayesian Machine Learning Approach to Identify Markers of Progression in Primary Angle Closure Glaucoma”
  Dr Monisha Nongpiur; S$75,000.00

• “Rational Design and Effectiveness of Cell-selective Anti-Microbial Peptides (ROADMAP) for Fungal Keratitis”
  Assoc Prof Lakshminarayanan Rajamani; S$765,302.00

• “INTEgRating bRain, Eye And Cardiac Research (INTER-REACH) : How the Scarecrow found a Brain, the Lion Vision to locate Courage and the Tin Man a Heart”
  Prof Leopold Schmetterer; S$1,269,000.00

• “Refinement and Prospective Validation of a Deep Learning Algorithm for Detecting Chronic Kidney Disease Using Retinal Images (RetiKid)”
  A/Prof Charumathi Sabanayagam; S$499,775.50

• “Risk Stratification of Neuropathic Ocular Surface Dysfunction Using Neural Imaging Metrics, Molecular Biomarkers, and Artificial Intelligence”
  Dr Liu Yu Chi; S$675,000.00

• “Widefield and Multi-modal Corneal Imaging to Investigate Corneal Endothelial Cell Loss following Descemet Membrane Endothelial Keratoplasty (DMEK)”
  A/Prof Marcus Ang; S$675,000.00

• “The Singapore Iymphoma Translational Study (SYMPHONY)”
  Dr Anita Chan; S$87,000.00

A*Star/ Duke-NUS/ MOH/ Others

• “Anti-Infective Nanocoating for Medical Devices”
  Assoc Prof Lakshminarayanan Rajamani; S$125,000.00

• “Digital and Precision Community Screening Platform for Ageing Diseases: Vision, Metabolism and Heart”
  Prof Cheng Ching Yu; S$2,199,260.00

• “MARIO: Multimodal AI-Driven Decision Making for Ophthalmology”
  Prof Wong Tien Yin; S$3,245,100.00

• “The Biomechanical Phenotype of Normal Tension Glaucoma”
  Assoc Prof Michael Girard; USD200,000

• “Artificial Intelligence in Medicine Transformation Program (AIMx)”
  Assoc Prof Daniel Ting; S$957,540.00

• “IMCB-NUS-SERI-XCell Joint lab: RECET (Regenerative Cell Therapies)”
  Prof Gemmy Cheung; S$300,000.00

• “Proteolytic Stability and Bioavailability of Branched Antifungal Peptide”
  Assoc Prof Lakshminarayanan Rajamani; S$50,000.00

• “Artificial Intelligence (AI) and Digital Health”
  Assoc Prof Daniel Ting; S$160,000.00

• “Minimally-invasive Treatment for Chronic Angle Closure Glaucoma”
  Assoc Prof Shamira Perera; S$175,200.00

• “Ocular Biomaterials for Vitreoretinal Therapeutic Applications (OrBiTAl)”
  Prof Gemmy Cheung & Prof Tina Wong; S$980,000.00
  

SingHealth

• “Structural Changes of the Optic Nerve Head in Different Body Positions in Subjects with Obstructive Sleep Apnea and Normaltension Glaucoma: A Pilot Study using Optical Coherence Tomography”
  Dr Tin Aung Tun; S$50,000.00

• “3D AI Technologies to Discriminate between Benign Optic Nerve Head Drusen and Potentially Life-threatening Papilledema due to Neurological Disorders”
  Assoc Prof Michael Girard; S$80,000.00

• “Retinal Vascular Imaging in the Healthy Early Life Moments in Singapore (HELMS) Model of Care”
  Dr Ng Wei Yan; S$150,000.00

• “Multi-centre implementation of artificial intelligence (AI)-based eye screening in Singapore”
  Dr Dinesh Gunasekeran; S$65,000.00

Commercial

• “A Phase IIIB, Global, Multicenter, Randomized, Visual Assessor-masked Study of the Efficacy, Safety, and Pharmacokinetics of a 36-week Refill Regimen for the Port Delivery System with Ranibizumab in Patients with Neovascular Age-related Macular Degeneration (Velodrome)”
  Clin Assoc Prof Lee Shu Yen; S$272,020.24

• “A Multicenter, Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Faricimab in Patients with Diabetic Macular Edema (RHONE-X)”
  Assoc Prof Gavin Tan; S$27,528.26

• “Single Site, Feasibility Study to Evaluate the Safety of the ENDOART® for Treatment of Subjects Suffering from Corneal Edema”
  Prof Jodhbir Mehta; S$149,938.71

• “A Multicenter, Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Faricimab in Patients with Neovascular Age-related Macular Degeneration (Avonelle-X)”
  Prof Gemmy Cheung; S$28,517.26

• “Retro-prospective Evaluation of the Clinical Safety and Effectiveness of Hydrophilic Acrylic Intraocular Lens”
  Dr Mohamad Rosman; S$141,641.93

• “Testing Small Molecule Compound in Laser-induced CNV in Non-Human Primate Model”
  Dr Amutha Barathi; S$272,993.49

• “Direct Selective Laser Trabeculoplasty for Primary Open Angle Glaucoma and Ocular Hypertension in Ethnic Chinese Population The Zhuiguang 追光 Trial”
  Assoc Prof Shamira Perera; S$165,595.79

• “Evaluation of Visual Outcomes in Patients with Complex Corneas Implanted with IC-8 IOL”
  Prof Jodhbir Mehta; S$69,993.32

• “To Establish In-vivo Baseline Efficacy of AAV2-RPE65 Gene Therapy by Subretinal Injection in a Murine Model of RD12 Mice”
  Prof Jodhbir Mehta; S$122,028.26

• “Evaluation of Anti-inflammatory Small Molecule Inhibitor in AKIMBA PDR Model”
  Dr Amutha Barathi; S$80,003.37

• “Clinical Investigation of the Cheetah System for the Correction of Myopic Refractive Errors with and Without Astigmatism”
  Prof Jodhbir Mehta; S$613,490.21