Grants FY14-15

NMRC

• “Development of xanthone-derived antibiotics as therapeutics for multidrug-resistant gram-positive pathogen infections”.
  Dr Liu Shou Ping; S$1,250,000.00

• “Rational design of synthetic mimics of antimicrobial peptides: From in silico to in vivo”.
  Dr Li Jianguo; S$199,500.00

• “Singapore age-related macular degeneration genetic architecture (SAGA) study: From population genomics to personalized medicine”.
  A/Prof Cheng Ching-Yu; S$668,071.17

• “The Singapore colour pupillometry evaluation (SCOPE): A novel detection test for glaucoma”.
  Prof Dan Milea; S$1,035,050.00

• “Next generation optical coherence tomography (OCT) for the cornea and anterior segments of the eye”.
  Dr Marcus Ang; S$195,829.00

• “Singapore angle closure glaucoma program: Characterization, prevention and management”.
  Prof Aung Tin; S$5,500,000.00

• “Neuroglobin in a primate experimental model of glaucoma: A novel neuroprotectant in glaucoma”.
  Dr Anita Chan; S$375,000.00

• “Assessing placental perfusion and fetal growth by examining maternal retina during pregnancy”.
  Dr Queenie Li Lingjun; S$375,000.00

• “Randomized controlled trial of lutein as a novel neuroprotective adjunctive therapy to improve visual outcome of rhegmatogenous retinal detachment (LUNAR Trial)”.
  Dr Ning Cheung; S$375,000.00

BMRC

• “SIPRAD - SERI-IMCB programme in retinal angiogenic diseases”.
  Prof Wong Tien Yin; S$9,900,000.00

A*Star/ Duke-NUS/ MOH/ Others

• “Roles of regulatory variants for LOXL1 in pseudoexfoliation glaucoma”.
  Prof Aung Tin; S$100,000.00

• “A novel diabetic macular edema screening model using spectral-domain optical coherence tomography in primary care setting in Singapore”.
  Dr Gavin Tan; S$300,000.00

• “Retinal microvascular abnormalities as predictors of decline in kidney function in the Singapore Indian eye study cohort”.
  Dr Charumathi Sabanayagam; S$197,398.00

• “Prevention of and intervention for eye diseases in the elderly [PROVIDE]”.
  Prof Ecosse Lamoureux; S$200,000.00

• “Improving diabetes and health outcomes: Enhancing health literacy in patients with diabetes and diabetic retinopathy”.
  Prof Ecosse Lamoureux; S$199,750.00

• “Translational PoC study of RO6897779 in NHP with ocular hypertension”.
  Dr Amutha Barathi Veluchamy; S$147,665.34

• “ATX in glaucoma – ATX inhibitor study in Dutch belted rabbits”.
  Dr Amutha Barathi Veluchamy; S$75,602.63

• “Efficacy of bispecific crossmab antibodies in model of laser induced CNV in NHP”.
  Dr Amutha Barathi Veluchamy; S$130,005.38

• “Validation of a novel micro-fluid cytokine analysis platform for aqueous and vitreous humour in normal and eyes with diabetic retinopathy”.
  Prof Wong Tien Yin; S$176,483.37

• “Randomised clinical trial of acupuncture and herbal treatment in dry eye: Cutting edge technologies meet traditional Chinese medicine”.
  A/Prof Louis Tong; S$265,634.00

• “Retina, imaging and epidemiology”.
  Prof Wong Tien Yin; S$1,500,000.00

SingHealth

• “Rational design of novel branched antimicrobial peptides”.
  Dr Li Jianguo; S$50,000.00

• “Optimization of anti-tuberculosis molecules by lipid tail modification of cationic amphiphilic a-mangostin derivatives and the membrane-targeting study”.
  Dr Liu Shou Ping; S$150,000.00

• “Antimicrobial peptide immobilization for preventing peri/post-operative artificial cornea implants associated infection”.
  Dr Gary Yam; S$149,862.00

• “Tear biomarkers for patients with thyroid orbitopathy”.
  Dr Zhou Lei; S$149,720.00

Commercial

• “Randomized, double-masked, vehicle controlled clinical evaluation to assess the safety and efficacy of nepafenac ophthalmic suspension, 0.3% for improvement in clinical outcomes among diabetic subjects following cataract surgery”.
  Adj A/Prof Edmund Wong; S$137,305.68

• “A randomised, double-masked, sham-controlled phase 3b/4 study of the efficacy, safety, and tolerability of intravitreal aflibercept monotherapy compared to aflibercept with adjunctive photodynamic therapy as indicated in subjects with polypoidal choroidal vasculopathy (PLANET)”.
  A/Prof Gemmy Cheung; S$116,736.92

• “Chronobiological effects of blocking blue light – the BLUES study (blocking light usefully for efficient sleep)”.
  Prof Dan Milea; S$164,056.63

• “Laser-induced choroidal neovascularization (CNV) in cynomolgus monkeys-age-related macular degeneration (AMD) model”.
  Dr Amutha Veluchamy Barathi; S$431,990.35

• “Choriodal neovascularization in Asians: Is there a difference in genetic background between age-related macular degeneration and polypoidal chorodial vasculopathy?”
  Prof Wong Tien Yin; S$286,352.95