Data Science and Data Management Platform
Data Science Platform
The Data Science Unit serves as a supporting platform to provide consultations across all the departments in SERI and SNEC. We assist in the planning and designing of studies, grant proposals, statistical analysis and manuscript reporting for any research theme. The team has worked on analyses on large-scale population-based studies in the Singapore Epidemiology of Eye Diseases (SEED) programme. They have also worked on clinical research projects and trials, genome-wide association studies, and other projects with various organisations, such as SNEC, DUKE-NUS Medical School, National University Health System, Tan Tock Seng Hospital, National University of Singapore, Genome Institute of Singapore and Institute of Molecular and Cell Biology.
We have an established reputation for being a leading centre for biostatistical methodologies relevant to eye research. Our work involves extensive inter-institutional and often international collaboration, undertaking research in applied projects and in statistical methodology.
Principal investigators, clinician scientists and research fellows from all research platforms and even outside of SERI are welcome to tap into the statistical expertise of the team. We provide the following services:
Study design and planning: Discussion with principal investigators, clinicians, scientists, and research fellows to understand their research aims and to assist in the planning and design of their research study. Consultations on sample size and power calculations for studies, as well as statistical analysis plans and statistical sections for grant application services are available from the statistical unit.
Statistical analysis and reporting: Post-study, primary and secondary analysis will be provided to investigate research aims. Statisticians will also collaborate in the writing of reports, abstracts and manuscripts, as well as assist in reviews. Further insights and sub-group analysis will also be investigated.
Statistical consulting: The statistical unit will also provide an avenue to discuss and resolve ad-hoc statistical questions or post-hoc analysis for researchers of all research themes.
Statistics workshop: Introductory biostatistics sessions (workshops) on specific topics will be made available upon request from researchers who would like to learn and perform their own analysis with statistical programs.
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Argon Laser Peripheral Iridoplasty for Primary Angle-Closure Glaucoma: A Randomized Controlled Trial. Narayanaswamy A, Baskaran M, Perera SA, Nongpiur ME, Htoon HM, Tun TA, Wong TT, Goh D, Su DH, Chew PT, Ho CL, Aung T., Ophthalmology. 2016 Mar;123(3):514-21.
Type 2 Diabetes Genetic Variants and Risk of Diabetic Retinopathy. Chong YH, Fan Q, Tham YC, Gan A, Tan SP, Tan G, Wang JJ, Mitchell P, Wong TY*, Cheng CY*., Ophthalmology. 2017 Mar;124(3):336-342.
Association of Systemic Medication Use With Intraocular Pressure in a Multiethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study. Ho H, Shi Y, Chua J, Tham YC, Lim SH, Aung T, Wong TY, Cheng CY., JAMA Ophthalmol. 2017 Mar 1;135(3):196-202.
Plasma Metabonomic Profiling of Diabetic Retinopathy. Chen L, Cheng CY, Choi H, Ikram MK, Sabanayagam C, Tan GS, Tian D, Zhang L, Venkatesan G, Tai ES, Wang JJ, Mitchell P, Cheung CM, Beuerman RW, Zhou L, Chan EC, Wong TY., Diabetes. 2016 Apr;65(4):1099-108.
Femtosecond laser-assisted conjunctival autograft preparation for pterygium surgery. Fuest M, Liu YC, Yam GH, Teo EP, Htoon HM, Coroneo MT, Mehta JS., Ocul Surf. 2017 Apr;15(2):211-217.
Interventions for the management of CMV-associated anterior segment inflammation. Anshu A, Tan D, Chee SP, Mehta JS, Htoon HM., Cochrane Database Syst Rev. 2017 Aug 24;8:CD011908.
Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration. Cheung CMG, Gan A, Fan Q, Chee ML, Apte RS, Khor CC, Ian Yeo, Mathur R, Cheng CY, Wong TY, Tai ES, J Lipid Res. 2017 Sep;58(9):1785-1796. doi: 10.1194/jlr.M073684. Epub 2017 Jul 11.
Long-term Visual Outcomes Comparing Descemet Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty. Fuest M, Ang M, Htoon HM, Tan D, Mehta JS., Am J Ophthalmol. 2017 Oct;182:62-71.
Development and Validation of a Deep Learning System for Diabetic Retinopathy and Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes. Ting DSW, Cheung CY, Lim G, Tan GSW, Quang ND, Gan A, Hamzah H, Garcia-Franco R, San Yeo IY, Lee SY, Wong EYM, Sabanayagam C, Baskaran M, Ibrahim F, Tan NC, Finkelstein EA, Lamoureux EL, Wong IY, Bressler NM, Sivaprasad S, Varma R, Jonas JB, He MG, Cheng CY, Cheung GCM, Aung T, Hsu W, Lee ML, Wong TY., JAMA. 2017 Dec 12;318(22):2211-2223. doi: 10.1001/jama.2017.18152.
Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. Sobrin L, Chong YH, Fan Q, Gan A, Stanwyck LK, Kaidonis G, Craig JE, Kim J, Liao WL, Huang YC, Lee WJ, Hung YJ, Guo X, Hai Y, Ipp E, Pollack S, Hancock H, Price A, Penman A, Mitchell P, Liew G, Smith AV, Gudnason V, Tan G, Klein BEK, Kuo J, Li X, Christiansen MW, Psaty BM, Sandow K; Asian Genetic Epidemiology Network Consortium, Jensen RA, Klein R, Cotch MF, Wang JJ, Jia Y, Chen CJ, Chen YI, Rotter JI, Tsai FJ, Hanis CL, Burdon KP, Wong TY, Cheng CY., Diabetes. 2017 Dec;66(12):3130-3141. doi: 10.2337/db17-0398. Epub 2017 Sep 26.
Association Between Perceived Barriers to Diabetes Self-management and Diabetic Retinopathy in Asian Patients With Type 2 Diabetes. Man REK, Fenwick EK, Gan ATL, Sabanayagam C, Gupta P, Aravindhan A, Wong TY, Tan GSW, Lamoureux EL., JAMA Ophthalmol. 2017 Dec 1;135(12):1387-1393.
Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia. Han Y, Dorajoo R, Chang X, Wang L, Khor CC, Sim X, Cheng CY, Shi Y, Tham YC, Zhao W, Chee ML, Sabanayagam C, Chee ML, Tan N, Wong TY, Tai ES, Liu J, Goh DYT, Yuan JM, Koh WP, van Dam RM, Low AF, Chan MY, Friedlander Y, Heng CK., Sci Rep. 2017 Dec 20;7(1):17921. doi: 10.1038/s41598-017-18214-z.
Association Between the Severity of Diabetic Retinopathy and Falls in an Asian Population With Diabetes: The Singapore Epidemiology of Eye Diseases Study Gupta P, Aravindhan A, Gan ATL, Man REK, Fenwick EK, Mitchell P, Tan N, Sabanayagam C, Wong TY, Cheng CY, Lamoureux EL, JAMA Ophthalmol. 2017 Dec 1;135(12):1410-1416. doi: 10.1001/jamaophthalmol.2017.4983.
The Effect of Testing Reliability on Visual Field Sensitivity in Normal Eyes: The Singapore Chinese Eye Study. Tan NYQ, Tham YC, Koh V, Nguyen DQ, Cheung CY, Aung T, Wong TY, Cheng CY., Ophthalmology. 2018 Jan;125(1):15-21.
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases Iglesias AI, Mishra A, Vitart V, Bykhovskaya Y, Hšhn R, Springelkamp H, Cuellar-Partida G, Gharahkhani P, Bailey JNC, Willoughby CE, Li X, Yazar S, Nag A, Khawaja AP, Pola?ek O, Siscovick D, Mitchell P, Tham YC, Haines JL, Kearns LS, Hayward C, Shi Y, van Leeuwen EM, Taylor KD; Blue Mountains Eye StudyÑGWAS group, Bonnemaijer P, Rotter JI, Martin NG, Zeller T, Mills RA, Staffieri SE, Jonas JB, Schmidtmann I, Boutin T, Kang JH, Lucas SEM, Wong TY, Beutel ME, Wilson JF; NEIGHBORHOOD Consortium; Wellcome Trust Case Control Consortium 2 (WTCCC2), Uitterlinden AG, Vithana EN, Foster PJ, Hysi PG, Hewitt AW, Khor CC, Pasquale LR, Montgomery GW, Klaver CCW, Aung T, Pfeiffer N, Mackey DA, Hammond C, Cheng CY, Craig JE, Rabinowitz YS, Wiggs JL, Burdon KP, van Duijn CM, MacGregor S, Nat Commun. 2018 May 14;9(1):1864. doi: 10.1038/s41467-018-03646-6.
Falls and Recurrent Falls among Adults in A Multi-ethnic Asian Population: The Singapore Epidemiology of Eye Diseases Study Dai W, Tham YC, Chee ML, Tan NYQ, Wong KH, Majithia S, Sabanayagam C, Lamoureux E, Wong TY, Cheng CY., Sci Rep. 2018 May 15;8(1):7575. doi: 10.1038/s41598-018-25894-8.
Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error Tedja MS, Wojciechowski R, Hysi PG, Eriksson N, Furlotte NA, Verhoeven VJM, Iglesias AI, Meester-Smoor MA, Tompson SW, Fan Q, Khawaja AP, Cheng CY, Hšhn R, Yamashiro K, Wenocur A, Grazal C, Haller T, Metspalu A, Wedenoja J, Jonas JB, Wang YX, Xie J, Mitcell P, Foster PJ, ein BEK, Klein R, Paterson AD, Hosseini SM, Shah RL, Williams C, Teo YY, Tham YC, Gupta P, Zhao W, Shi Y, Saw WY, Tai ES, Sim XL, Huffman JE, Pola?ek O, Hayward C, Bencic G, Rudan I, Wilson JF; CREAM Consortium; 23andMe Research Team; UK Biobank Eye and Vision Consortium, Joshi PK, Tsujikawa A, Matsuda F, Whisenhunt KN, Zeller T, van der Spek PJ, Haak R, Meijers-Heijboer H, van Leeuwen EM, Iyengar SK, Lass JH, Hofman A, Rivadeneira F, Uitterlinden AG, Vingerling JR, LehtimŠki T, Raitakari OT, Biino G, Concas MP, Schwantes-An TH, Igo RP Jr, Cuellar-Partida G, Martin NG, Craig JE, Gharahkhani P, Williams KM, Nag A, Rahi JS, Cumberland PM, Delcourt C, Bellenguez C, Ried JS, Bergen AA, Meitinger T, Gieger C, Wong TY, Hewitt AW, Mackey DA, Simpson CL, Pfeiffer N, PŠrssinen O, Baird PN, Vitart V, Amin N, van Duijn CM, Bailey-Wilson JE, Young TL, Saw SM, Stambolian D, MacGregor S, Guggenheim JA, Tung JY, Hammond CJ, Klaver CCW., Nat Genet. 2018 Jun;50(6):834-848. doi: 10.1038/s41588-018-0127-7. Epub 2018 May 28.
Prof Cheng Ching-Yu
Dr Htoon Hla Myint (Senior Research Fellow)
Alfred Gan Tau Liang (Senior Biostatistician)
Chee Miao Li (Biostatistician)
Nguyen Duc Quang (Biostatistician)
Link to SEED website:
The Data Management Unit (DMU) serves to support all research and clinical studies across SERI and SNEC that require complete data management, starting from Case Report Form designing to preparing cleaned de-identified datasets following the GCDMP, HBRA and PDPA guidelines.
DMU is fully trained for:
Best DM practices, Data Management policies and procedures
Programming and computerised system validations to ensure high quality and well organized databases with thorough documentation
At present, DMU is working on numerous SERI and SNEC projects from database design to data entry, quality checks and maintenance. DMU consists of an assistant director, senior executive, executive and DM associates working on large population based epidemiological cross-sectional studies, cohort studies, clinical trials, genome-wide association studies, laboratory data and other projects with various organizations, such as NUHS, NUS and overseas partners. Besides clinical research projects, DMU is involved in developing a robust electronic data capture system (EDC) required for various departments in SERI and SNEC, using object-oriented programming languages.
Prof Ecosse Lamoureux
Sophia Man She Yunn
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