Theme 1 (Population Health) will determine how common AMD/PCV is and the factors leading to increased risk of AMD/PCV in Asians to help plan future preventative interventions.
Theme 2 (Pathophysiology) will examine the underlying pathophysiological changes at the cellular/molecular/genetic level in AMD through cell-based and animal experiments.
Theme 3 (Novel Imaging Biomarkers) will exploit a multitude of novel imaging technologies in collaboration with industry partners to find ways in which imaging can help guide treatment to achieve better outcomes.
Theme 4 (Therapy) will test and develop new therapeutic strategies through multi-centre clinical trials.
Theme 5 (Quality Of Life) will determine how AMD/PCV affects the quality of life among Asian patients, the cost of healthcare and also investigate the effect of new behavioral therapy to improve coping strategies among patients.
Our 5-year Vision
To develop paradigm shifts in our conceptualisation and understanding of Asian AMD, including PCV, that will lead to novel classification and evidence-based cost effective diagnostics, prevention and treatment strategies.
Clinical and Healthcare Significance
Mediacorp radio, CNA 938 Live, 3 Feb 2021Title: Live interview with Dr Kelvin Teo (Consultant, Medical Retina Department, SNEC). The interview discussed key findings from a research on local AMD patients
Mediacorp Channel 5 – Body and Soul – Episode 5, Dec 2020Title:
Dr Kelvin Teo discussed Age-related Macular Degeneration and the use of the Alleye app for self-monitoring of retinal diseases
The Straits Times, 18 April 2018Title:
MOH awards $60M to 3 research projects
SingVision, 15 Oct 2018, Issue 2 (2018)Title:
SERI and SNEC awarded $24M grant for AMD study
The Straits Times, 1 Aug 2020Title:
Timely eye injections help preserve vision. Interviews with Prof Gemmy Cheung and Dr Kelvin Teo
BioSpectrum Asian Edition, 28 February 2020Title:
Gemini Therapeutics and SERI to explore new targets for AMD
Channel News Asia, 7 Jan 2020Title:
STANCE NTU collaboration
Touch Medical Media Services, Euretina Congress 2019, 13 Sept 2019Title:
Clinical Characteristics in AMD
938NOW, 23 May 2019Title:
Professor Gemmy Cheung invited for a radio interview with Daniel Martin
The Straits Times, 1 Dec 2018Title:
Sights set on more effective way to treat eye diseases
Rim, T. H., Kawasaki, R., Tham, Y. C., Kang, S. W., Ruamviboonsuk, P., Bikbov, M. M., Miyake, M., Hao, J., Fletcher, A., Sasaki, M., Nangia, V., Sabanayagam, C., Yu, M., Fujiwara, K., Thapa, R., Wong, I. Y., Kayama, T., Chen, S. J., Kuang, T. M., Yamashita, H., … Asian Eye Epidemiology Consortium (2020). Prevalence and Pattern of Geographic Atrophy in Asia: The Asian Eye Epidemiology Consortium. Ophthalmology, 127(10), 1371–1381.
Ho, S. Y., Kwan, Y. P., Qiu, B., Tan, A., Murray, H. L., Barathi, V. A., Tan, N. S., Cheung, C., Wong, T. Y., Wahli, W., & Wang, X. (2020). Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ/δ-Deficient Mice. International journal of molecular sciences, 21(12), 4403.
Yao, X., Ke, M., Ho, Y., Lin, E., Wong, D., Tan, B., Schmetterer, L., & Chua, J. (2020). Comparison of retinal vessel diameter measurements from swept-source OCT angiography and adaptive optics ophthalmoscope. The British journal of ophthalmology, bjophthalmol-2020-316111.
Gemmy Cheung, C. M., Lai, T., Teo, K., Ruamviboonsuk, P., Chen, S. J., Kim, J. E., Gomi, F., Koh, A. H., Kokame, G., Jordan-Yu, J. M., Corvi, F., Invernizzi, A., Ogura, Y., Tan, C., Mitchell, P., Gupta, V., Chhablani, J., Chakravarthy, U., Sadda, S. R., Wong, T. Y., … Lee, W. K. (2020). Polypoidal Choroidal Vasculopathy: Consensus Nomenclature and Non-ICGA Diagnostic Criteria from the Asia-Pacific Ocular Imaging Society (APOIS) PCV Workgroup. Ophthalmology, S0161-6420(20)30784-3.
Patients and Participants
TAAP Clinical Trials (recruiting)
Analysis of the Pachychoroid Phenotype in an Asian Population
Long-term Outcomes, Recurrence Rates, and Treatment Needs in Polypoidal Choroidal Vasculopathy (PCV)
Comparing Intravitreal Aflibercept Monotherapy vs Aflibercept Combined With Reduced Fluence PDT in PCV Treatment
If you are interested in participating in the clinical trials, please contact us
Research and Industry Collaborators
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