CLINICAL SERVICES - CORNEAL & EXTERNAL EYE DISEASE

RESEARCH

A Selection of Our Publications

Corneal Transplantation and Corneal Infections

1. Anshu A, Parthasarathy A, Mehta JS, Htoon HM, Tan DT. Outcomes of therapeutic deep lamellar keratoplasty and penetrating keratoplasty for advanced infectious keratitis: a comparative study.  Ophthalmology. 2009 Apr;116(4):615-23. Epub 2009 Feb 25.
    
2. Tan DT, Anshu A, Mehta JS. Paradigm shifts in corneal transplantation. Ann Acad Med Singapore. 2009 Apr;38(4):332-8.
    
3. Anshu A, Chee SP, Mehta JS, Tan DT. Cytomegalovirus endotheliitis in Descemet's stripping endothelial keratoplasty. Ophthalmology. 2009 Apr;116(4):624-30. Epub 2009 Feb 4.
    
4. Ang M, Mehta JS, Arundhati A, Tan DT. Anterior lamellar keratoplasty over penetrating keratoplasty for optical, therapeutic, and tectonic indications: a case series. Am J Ophthalmol. 2009 Apr;147(4):697-702.e2. Epub 2008 Dec 5.
    
5. Tan DT, Janardhanan P, Zhou H, Chan YH, Htoon HM, Ang LP, Lim LS. Penetrating keratoplasty in Asian eyes: the Singapore Corneal Transplant Study. Ophthalmology. 2008 Jun;115(6):975-982.e1. Epub 2007 Dec 3.
    
6. Parthasarathy A, Tan DT. Deep lamellar keratoplasty for acanthamoeba keratitis. Cornea. 2007 Sep;26(8):1021-3.
    
7. Susiyanti M, Mehta JS, Tan DT. Bilateral deep anterior lamellar keratoplasty for the management of bilateral post-LASIK mycobacterial keratitis. J Cataract Refract Surg. 2007 Sep;33(9):1641-3.
    
8. Ti SE, Scott JA, Janardhanan P, Tan DT. Therapeutic keratoplasty for advanced suppurative keratitis. Am J Ophthalmol. 2007 May;143(5):755-762. Epub 2007 Feb 28.
    
9. Tong L, Tan DT, Abańo JM, Lim L. Deep anterior lamellar keratoplasty in a patient with descemetocele following gonococcal keratitis. Am J Ophthalmol. 2004 Sep;138(3):506-7.
    
10. Chan CM, Wong TY, Yeong SM, Lim TH, Tan DT. Penetrating keratoplasty in the Singapore National Eye Centre and donor cornea acquisition in the Singapore Eye Bank. Ann Acad Med Singapore. 1997 Jul;26(4):395-400.
     
11. Wong TY, Chan C, Lim L, Lim TH, Tan DT. Changing indications for penetrating keratoplasty: a newly developed country's experience. Aust N Z J Ophthalmol. 1997 May;25(2):145-50.
     
12. Tseng PS, Tan DT, Yong VS. Singapore General Hospital's experience in corneal grafting. Ann Acad Med Singapore. 1991 Jul;20(4):429-32. 

Pterygium

1. Zhou L, Beuerman RW, Ang LP, Chan CM, Li SF, Chew FT, Tan DT. Elevation of human alpha-defensins and S100 calcium-binding proteins A8 and A9 in tear fluid of patients with pterygium. Invest Ophthalmol Vis Sci. 2009 May;50(5):2077-86. Epub 2009 Jan 24.
    
2. Tong L, Chew J, Yang H, Ang LP, Tan DT, Beuerman RW. Distinct gene subsets in pterygia formation and recurrence: dissecting complex biological phenomenon using genome wide expression data. BMC Med Genomics. 2009 Mar 10;2:14.
    
3. Ang LP, Chua JL, Tan DT. Current concepts and techniques in pterygium treatment. Curr Opin Ophthalmol. 2007 Jul;18(4):308-13. Review.
    
4. Wong YW, Chew J, Yang H, Tan DT, Beuerman R. Expression of insulin-like growth factor binding protein-3 in pterygium tissue. Brit J Ophthalmol. 2006 Jun;90(6):769-72. Epub 2006 Feb 17.
    
5. Ang LP, Tan DT, Cajucom-Uy H, Beuerman RW. Autologous cultivated conjunctival transplantation for pterygium surgery. Am J Ophthalmol. 2005 Apr;139(4):611-9.
    
6. Sakoonwatanyoo P, Tan DT, Smith DR. Expression of p63 in pterygium and normal conjunctiva. Cornea. 2004 Jan;23(1):67-70.
    
7. Gazzard G, Saw SM, Farook M, Koh D, Widjaja D, Chia SE, Hong CY, Tan DT. Pterygium in Indonesia: prevalence, severity and risk factors. Brit J Ophthalmol. 2002 Dec;86(12):1341-6.
    
8. Chan CM, Liu YP, Tan DT. Ocular surface changes in pterygium. Cornea. 2002 Jan;21(1):38-42.
    
9. Chan CM, Chew PT, Alsagoff Z, Wong JS, Tan DT. Vascular patterns in pterygium and conjunctival autografting: a pilot study using indocyanine green anterior segment angiography. Brit J Ophthalmol. 2001 Mar;85(3):350-3.
    
10. Wong TY, Foster PJ, Johnson GJ, Seah SK, Tan DT. The prevalence and risk factors for pterygium in an adult Chinese population in Singapore: the Tanjong Pagar survey. Am J Ophthalmol. 2001 Feb;131(2):176-83.
     
11. Alsagoff Z, Tan DT, Chee SP. Necrotising scleritis after bare sclera excision of pterygium. Brit J Ophthalmol. 2000 Sep;84(9):1050-2.
     
12. Tan DT, Liu YP, Sun L. Flow cytometry measurements of DNA content in primary and recurrent pterygia. Invest Ophthalmol Vis Sci. 2000 Jun;41(7):1684-6.
     
13. Lee SB, Li DQ, Tan DT, Meller DC, Tseng SC. Suppression of TGF-beta signaling in both normal conjunctival fibroblasts and pterygial body fibroblasts by amniotic membrane. Curr Eye Res. 2000 Apr;20(4):325-34.
     
14. Saw SM, Banerjee K, Tan D. Risk factors for the development of pterygium in Singapore: a hospital-based case-control study. Acta Ophthalmol Scand. 2000 Apr;78(2):216-20.
     
15. Ti SE, Chee SP, Dear KB, Tan DT. Analysis of variation in success rates in conjunctival autografting for primary and recurrent pterygium. Brit J Ophthalmol. 2000 Apr;84(4):385-9.
     
16. Tan DT, Tang WY, Liu YP, Goh HS, Smith DR. Apoptosis and apoptosis related gene expression in normal conjunctiva and pterygium. Brit J Ophthalmol. 2000 Feb;84(2):212-6.
     
17. Saw SM, Tan D. Pterygium: prevalence, demography and risk factors. Ophthalmic Epidemiol. 1999 Sep;6(3):219-28. Review.
     
18. Jap A, Chan C, Lim L, Tan DT. Conjunctival rotation autograft for pterygium. An alternative to conjunctival autografting. Ophthalmology. 1999 Jan;106(1):67-71.
     
19. Fong KS, Balakrishnan V, Chee SP, Tan DT. Refractive change following pterygium surgery. CLAO J. 1998 Apr;24(2):115-7.
     
20. Khoo J, Saw SM, Banerjee K, Chia SE, Tan D. Outdoor work and the risk of pterygia: a case-control study. Int Ophthalmol. 1998;22(5):293-8.
     
21. Tan DT, Chee SP, Dear KB, Lim AS. Effect of pterygium morphology on pterygium recurrence in a controlled trial comparing conjunctival autografting with bare sclera excision. Arch Ophthalmol. 1997 Oct;115(10):1235-40. Erratum in: Arch Ophthalmol 1998 Apr;116(4):552.
     
22. Yip CC, Lim L, Tan DT. The surgical management of an advanced pterygium involving the entire cornea. Cornea. 1997 May;16(3):365-8.
     
23. Tan DT, Lim AS, Goh HS, Smith DR. Abnormal expression of the p53 tumor suppressor gene in the conjunctiva of patients with pterygium. Am J Ophthalmol. 1997 Mar;123(3):404-5.

Dry Eye

1. Tong L, Saw SM, Lamoureux EL, Wang JJ, Rosman M, Tan DT, Wong TY. A questionnaire-based assessment of symptoms associated with tear film dysfunction and lid margin disease in an Asian population. Ophthalmic Epidemiol. 2009 Jan-Feb;16(1):31-7. Erratum in: Ophthalmic Epidemiol. 2009 Mar-Apr;16(2):142. Tongg, Louis [corrected to Tong, Louis].
    
2. Tong L, Wong TY. Aspirin and dry eye? Ophthalmology. 2009 Jan;116(1):167-167.
    
3. Chen S, Tong L. Letter to editor: Comparison of two artificial tear formulations using aberrometry
   accepted 2009 Clinical and Experimental Optometry.
    
4. Toshida H, Nguyen DH, Beuerman RW, Murakami A. Neurologic evaluation of acute lacrimomimetic effect of cyclosporine in an experimental rabbit dry eye model. Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2736-41. Epub 2009 Feb 14.
    
5. Chen Z, Tong L, Li Z, Yoon KC, Qi H, Farley W, Li DQ, Pflugfelder SC. Hyperosmolarity-induced cornification of human corneal epithelial cells is regulated by JNK MAPK. Invest Ophthalmol Vis Sci. 2008 Feb;49(2):539-49. 
    
6. Toshida H, Nguyen DH, Beuerman RW, Murakami A. Neurologic evaluation of acute lacrimomimetic effect of cyclosporine in an experimental rabbit dry eye model. Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2736-41. Epub 2009 Feb 14.
    
7. Toshida H, Nguyen DH, Beuerman RW, Murakami A. Evaluation of novel dry eye model: preganglionic parasympathetic denervation in rabbit. Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4468-75.
    
8. Zhou L, Beuerman RW, Foo Y, Liu S, Ang LP, Tan DT. Characterisation of human tear proteins using high-resolution mass spectrometry. Ann Acad Med Singapore. 2006 Jun;35(6):400-7. 
    
9. Tong L, Corrales RM, Chen Z, Villarreal AL, De Paiva CS, Beuerman R, Li DQ, Pflugfelder SC. Expression and regulation of cornified envelope proteins in human corneal epithelium. Invest Ophthalmol Vis Sci. 2006 May;47(5):1938-46.
    
10. Nguyen DH, Vadlamudi V, Toshida H, Beuerman RW. Loss of parasympathetic innervation leads to sustained expression of pro-inflammatory genes in the rat lacrimal gland. Auton Neurosci. 2006 Jan 30;124(1-2):81-9. Epub 2006 Feb 2.   
     
11. Beuerman RW, Stern ME. Neurogenic inflammation: a first line of defense for the ocular surface.  Ocul Surf. 2005 Oct;3(4 Suppl):S203-6.
     
12. Pflugfelder SC, de Paiva CS, Tong L, Luo L, Stern ME, Li DQ. Stress-activated protein kinase signaling pathways in dry eye and ocular surface disease. Ocul Surf. 2005 Oct;3(4 Suppl):S154-7.
     
13. Nguyen DH, Toshida H, Schurr J, Beuerman RW. Microarray analysis of the rat lacrimal gland following the loss of parasympathetic control of secretion. Physiol Genomics. 2004 Jun 17;18(1):108-18.
     
14. Stern ME, Gao J, Siemasko KF, Beuerman RW, Pflugfelder SC. The role of the lacrimal functional unit in the pathophysiology of dry eye. Exp Eye Res. 2004 Mar;78(3):409-16. Review. 
     
15. Zhou L, Beuerman RW, Barathi A, Tan D. Analysis of rabbit tear proteins by high-pressure liquid  chromatography/electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom. 2003;17(5):401-12.
     
16. Lee AJ, Lee J, Saw SM, Gazzard G, Koh D, Widjaja D, Tan DT. Prevalence and risk factors associated with dry eye symptoms: a population based study in Indonesia. Brit J Ophthalmol. 2002 Dec;86(12):1347-51. Review.
     
17. Toshida H, Beuerman RW. Effects of preganglionic parasympathetic denervation on the rabbit lacrimation. Adv Exp Med Biol. 2002;506(Pt A):225-9.
     
18. Nguyen DH, Beuerman RW, Toshida H. The effects of sensory and parasympathetic denervation on the kinases and initiation factors controlling protein synthesis in the lacrimal gland. Adv Exp Med Biol. 2002;506(Pt A):65-70.
     
19. Maitchouk DY, Beuerman RW, Ohta T, Stern M, Varnell RJ. Tear production after unilateral removal of the main lacrimal gland in squirrel monkeys. Arch Ophthalmol. 2000 Feb;118(2):246-52.  
     
20. Salvatore MF, Pedroza L, Beuerman RW. Denervation of rabbit lacrimal gland increases levels of transferrin and unidentified tear proteins of 44 and 36 kDa. Curr Eye Res. 1999 Jun;18(6):455-66.
     
21. Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC. A unified theory of the role of the ocular surface in dry eye. Adv Exp Med Biol. 1998;438:643-51. Review.
     
22. Maitchouk DY, Beuerman RW, Varnell RJ, Pedroza-Schmidt L. Effects of lacrimal gland removal on squirrel monkey cornea. Adv Exp Med Biol. 1998;438:619-24.
     
23. Nguyen DH, Beuerman RW, Meneray MA, Maitchouk D. Sensory denervation leads to deregulated protein synthesis in the lacrimal gland. Adv Exp Med Biol. 1998;438:55-62. No abstract available.
     
24. Varnell RJ, Freeman JY, Maitchouk D, Beuerman RW, Gebhardt BM. Detection of substance P in human tears by laser desorption mass spectrometry and immunoassay. Curr Eye Res. 1997 Sep;16(9):960-3. 
     
25. Nguyen DH, Beuerman RW, Thompson HW, DiLoreto DA. Growth factor and neurotrophic factor mRNA in human lacrimal gland. Cornea. 1997 Mar;16(2):192-9.
     
26. Varnell RJ, Maitchouk DY, Beuerman RW, Salvatore MF, Carlton JE, Haag AM. J Capillary. Analysis of rabbit tear fluid using capillary electrophoresis with UV or laser-induced fluorescence detection. Electrophor. 1997 Jan-Feb;4(1):1-6.
     
27. Beuerman RW, Laird JA, Kaufman SC, Kaufman HE. Quantification of real-time confocal images of the human cornea. J Neurosci Methods. 1994 Oct;54(2):197-203.

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Read more on related Eye Conditions and Treatments:

Corneal Infections
Dry Eye
Eye Infections
Pterygium