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Vortioxetine

Drug Class: Commonly Known As: Category:
Multimodal Serotogenic Antidepressant Brintellix Adult

Vortioxetine - What is it for

Vortioxetine belongs to a class of medications known as Multimodal Serotonergic antidepressant. It is used to treat symptoms of depression (low mood) such as:

  • Feeling sad
  • Feeling hopeless or useless
  • Feeling bad about yourself
  • Thoughts of ending your life
  • Poor sleep, energy or appetite.

This medication may be used for other conditions. Check with your healthcare professional if you are unsure why you are given this medication.

Vortioxetine - Side Effects, Precautions, and Contraindications

What side effects can Vortioxetine cause?

Side effects which generally affect up to 10% of patients include:

  • Nausea, vomiting or loss of appetite
    • Take the medication with or after food.
    • Take small but frequent meals and avoid fatty or spicy food
  • Diarrhoea
    • Drink plenty of water to replace the loss of fluids
  • Constipation (difficulty passing motion)
    • Drink more water (if you do not have any fluid restriction), eat more high- fibre foods, and exercise regularly
    • Consult your doctor or pharmacist if you need medication to relieve your condition.
  • Dizziness
    • Get up slowly from a sitting or lying down position
  • Dry mouth
    • Chew sugar-free gum, suck on sugar-free hard candies or ice chips, sip water regularly
  • Dreams that are different from usual, decreased sexual drive or ability
    • Speak to your doctor if any of these affect your daily life

Most of the side effects listed here will improve with time. Speak with your doctor if they continue, get worse or are affecting your daily life.

Very rarely (affect less than 1% of patients) this medication may cause:

  • Unexplained fever, confusion, fast heartbeat, severe weakness, uncontrolled movements or twitching of muscles (signs and symptoms of Serotonin syndrome)
  • Feelings of intense agitation or anxiety, restlessness or inability to sit still
  • Talking, feeling, and acting with excitement that you cannot control
  • Fits (seizures) 
  • Blurred vision
  • Black sticky stools, unexplained bruising or bleeding

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking Vortioxetine, what precautions must I follow?

Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication
  • You are pregnant, planning to become pregnant, or breastfeeding. If you are pregnant and/or breastfeeding, your doctor would have discussed the potential benefits and side-effects with you and should you have further questions or concerns, do consult your doctor.
  • You have or have ever had:
    • Other drug allergies
    • Medical conditions such as fits (seizures), low sodium in the blood (hyponatremia), liver disease, eye or bleeding problems
    • Other mental health conditions such as bipolar disorder, or abnormally high or excited mood (mania)
    • Been taking other medications for low mood in the past 2 weeks.

IMPORTANT:

If you notice any changes in your mental condition especially in the first few weeks of treatment and during dose changes, you need to check with your doctor immediately. Do watch for any of the following changes in mental condition:

  • New or increasing thoughts of harming yourself
  • Worsening anxiety, restlessness, violent behaviour, or
  • Other changes in mood or behaviour.

Be sure that your family or caregiver are also aware of the above symptoms so they can call your doctor if you are unable to seek treatment on your own.

What food or medicine must I avoid when I take Vortioxetine?

Avoid drinking alcohol while taking this medication as it may make you feel very drowsy. This medication may interact with other medications. If you intend to take any over the counter medication, supplements, herbal remedy or traditional Chinese medicine, consult your doctor or healthcare professional first to confirm that it is safe to take with Vortioxetine.

Vortioxetine - Dosage and How to Use

How should Vortioxetine be used?

  • Follow the instructions on your medication label and take this medication as prescribed by your doctor.
  • This medication may be taken with or without food.
  • This medication needs to be taken regularly for a few weeks before you feel its full benefits. You should not stop taking this medication even if you do not feel better at the beginning. Continue to take this medication even after you feel better to prevent your symptoms from returning.
  • Do check with your doctor on how long you will have to be on this medication.
  • Do not stop taking your medication without checking with your healthcare professional. You may experience unpleasant effects such as dizziness, headache, difficulty sleeping, irritability, and nausea if you suddenly stop taking the medication on your own.

What should I do if I miss a dose?

If you forget to take a dose, take it as soon as you remember. However, if it is more than half of the time to the next dose, skip the missed dose and take the next dose at your usual timing. Do not take two doses to make up for the missed dose.

What should I do if I overdose?

Vortioxetine - Handling

How should I handle Vortioxetine safely?

Vortioxetine - Storage

How should I store Vortioxetine?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#

How should I dispose of Vortioxetine safely?

Pack this medication into a trash bag and seal it tightly before throwing into the rubbish chute or bin.

Vortioxetine - Additional Information

  • Tags: Vortioxetine
  • Updated on Tuesday, June 30, 2020
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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