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Drospirenone (Slinda)

Drug Class: Commonly Known As: Category:
Contraceptive Slinda

Drospirenone (Slinda) - What is it for

Slinda® (Drospirenone 4mg) tablets are progestogen-only pills, used for the prevention of pregnancy.

Drospirenone (Slinda) - Side Effects, Precautions, and Contraindications

What side effects can Drospirenone (Slinda) cause?

​Common side effects include:

  • Spotting or bleeding may occur between your menses during the first few months of taking Slinda®. With continued use, some patients may not have menses at all while taking Slinda®. This is normal. Inform your doctor:
    • If you do not have your menses AND you have not been taking your tablets correctly (i.e. missed doses) because there is a need to rule out pregnancy. 
    • If you are having heavy and continuous bleeding as it may lead to anaemia.
    • If you are having any other abnormal vaginal bleeding.
  • Stomach discomfort such as nausea and vomiting
    • Take it after food to minimise gastric side effects
  • Breast tenderness
  • Headache
    • You may take painkillers such as Paracetamol to manage headaches
  • Acne
  • Mood changes (mood swings or low mood)
    • Take the medication at the same time every day to avoid huge changes in the hormone levels in your body 
  • Weight gain
  • Decreased sexual drive
Inform your doctor if the side effects above become severe and bothersome.

Very rarely, this medication may cause:

  • Very bad, unusual headache
  • Sudden changes to your sight or speech
  • Very bad pain in your chest
  • Unusual pain or swelling of your legs
  • Dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking Drospirenone (Slinda) , what precautions must I follow?

Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication
  • You are pregnant, planning to become pregnant, or breastfeeding
  • You are taking any other medications, including supplements, traditional medications and herbal remedies.
  • You have a history of or current medical conditions such as liver problems, kidney problems, high potassium levels, stroke, clotting disorders, heart diseases, migraine headaches, epilepsy (fits), diabetes or cancer.

What food or medicine must I avoid when I take Drospirenone (Slinda) ?

  • Some medications might interact with this medication. Check with your healthcare professional if you want to take any other medicines, supplements or herbal products.
  • If you see another healthcare professional, inform him that you are taking this medication before he prescribes any other medications.

Drospirenone (Slinda) - Dosage and How to Use

How should Drospirenone (Slinda) be used?

  • Do not stop taking your medication without checking with your healthcare professional.
  • This medication should be taken after food.
  • Each pack contains 24 white (active) tablets and 4 green (inactive) tablets = 28 tablets.
  • You should take one tablet daily for 28 days in a row, preferably at the same time every day. You must take the tablets in the correct sequence i.e. start each pack with the white (active) tablets, followed by the green (inactive) tablets. 
  • The next pack is started after the last tablet of the previous pack. Withdrawal bleeding usually starts on day 2-3 after starting the green (inactive) tablets and may not have finished before the next pack is started.
  • A reliable supplementary non-hormonal contraceptive method such as condoms, are usually recommended for the first seven days of taking Slinda®, for e.g. if you start on Days 2 – 5 of your period, you should use a reliable supplementary non-hormonal contraceptive method for the first 7 days of tablet-taking. However, no additional contraceptive precautions are necessary if Slinda® is taken for the following scenarios below:
    • Day 1 of menstrual cycle (pregnancy should be ruled out before starting the medication).
    • Immediately after miscarriage or abortion
    • Day 21 – 28 after childbirth whether you are breastfeeding or not
    • When switching immediately from another progestogen-only pill (no break between switch in pills), implant, injection or intrauterine device 
    • When switching from a combined pill (COC), vaginal ring or transdermal patch without any tablet-, ring- or patch-free break.

What should I do if I miss a dose?

There is no action needed if you have missed the green (inactive) tablets; however, you must follow the steps below if you miss any of your 24 white (active) tablets to ensure that contraception effect is not reduced.

Within 24 hours:
Take the missed tablet as soon as remembered, then continue taking the next one at your usual time.

More than 24 hours:
If the missed tablet is during
  • Days 1 – 7 of the pack
    • Take the missed tablet as soon as you remember, even if it means taking 2 tablets at the same time.
    • Continue to take your tablets at your usual time. 
    • Use a barrier method such as a condom for the next 7 days.
  • Days 8 – 17 of the pack
    • Take the missed tablet as soon as you remember, even if it means taking 2 tablets at the same time. 
    • Continue to take your tablets at your usual time. 
    • If you have taken your tablets correctly in the 7 days before the first missed tablet, there is no need to use extra contraceptive precautions. However, if this is not the case, or you have missed more than 1 tablet, use a barrier method such as a condom for the next 7 days.
  • Days 18 - 24 of the pack:  Depending on whether you have taken your tablets correctly in the 7 days before the first missed tablet, you would have to follow the following options:  
​No missed tablets in the last 7 days

​Take the missed tablet as soon as you remember, even if it means taking 2 tablets at the same time.

Continue to take your tablets at your usual time until the white (active) tablets are finished. Throw away the 4 green (inactive) tablets and start the next pack right away. Your menses may not come until you finish taking all the white (active) tablets of the next pack, but there is no need to worry.  However, if your menses does not occur after the next pack is finished, you should take a pregnancy test to rule out pregnancy.

No additional  barrier method such as a condom is necessary.

OR

Stop the current pack and have a tablet-free period of up to 4 days (including the day you missed the tablet) - during which time a withdrawal bleed (menses) usually occurs and then continue with the next pack.

No additional  barrier method such as a condom is necessary.

​Missed tablets in the last 7 days

​Take the missed tablet as soon as you remember, even if it means taking 2 tablets at the same time.

Continue to take your tablets at your usual time until the white (active) tablets are finished. Throw away the 4 green (inactive) tablets and start the next pack right away. Your menses may not come until you finish taking all the white (active) tablets of the next pack, but there is no need to worry. However, if your menses does not occur after the next pack is finished, you should take a pregnancy test to make sure you are not pregnant.

AND

Use a barrier method such as a condom for the next 7 days

**If you miss your period (especially with missed tablets), check with your doctor to find out if you are pregnant before continuing to take the next cycle of contraceptives.

If you vomit or suffer from diarrhea within 3 to 4 hours of taking this medication, the tablet may not be absorbed. This is considered a missed dose. You should then follow the instructions above.

What should I do if I overdose?

Drospirenone (Slinda) - Handling

How should I handle Drospirenone (Slinda) safely?

Drospirenone (Slinda) - Storage

How should I store Drospirenone (Slinda) ?

;#Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#

How should I dispose of Drospirenone (Slinda) safely?

Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin. 

Drospirenone (Slinda) - Additional Information

  • Updated on 2/20/2023 12:00:00 AM
  • Article contributed by Pharmacy Department KK Women's and Children's Hospital
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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