You are invited to attend this seminar hosted by the Institute of Molecular and Cell Biology:
Date: Friday, 23 June 2023
Time: 11.00AM – 12.00PM
Venue: IMCB Seminar Room 03-46, Level 3 Proteos, Biopolis, Singapore 138673 (Physical)
Speaker: Prof Carla V. Rothlin, Yale School of Medicine
Host: Prof Vinay Tergaonkar, IMCB
Decoding the Effector Response to Cell Death
Abstract
Cell death manifests through a panoply of molecular pathways. We postulated that the tissue effector response to cellular corpses is similarly diverse. Apoptotic cell death in the lung, in the context of helminth infection and an IL-4-rich environment, is sensed by macrophages to direct resolution of inflammation and a tissue repair gene expression program. Apoptotic cell death, however, is commonplace in the gut and integral to homeostatic tissue renewal in this organ. Another specific molecularly-executed cell death modality – necroptosis – has been reported in the gut in settings of non-resolving inflammation and tissue damage, such as in inflammatory bowel disease. I will present and discuss our recent findings on the effector response to necroptotic corpses. Taken together, our findings indicate to an invariant code that informs effector tissue responses based on type, context and sensor of cell death.
Biography
Carla Rothlin studied Biochemistry and Pharmacy at the University of Buenos Aires, where she also performed her graduate studies under the direction of Ana Belen Elgoyhen. Carla Rothlin’s Ph.D. work centered on nicotinic receptors expressed in the inner ear. Following her Ph.D., Carla Rothlin was awarded a Pew Latin American Fellowship and moved to San Diego, California where she joined Greg Lemke's lab at the Salk Institute for Biological Studies. During her postdoctoral studies Carla Rothlin defined the role of the TAM Receptor Tyrosine Kinases in the regulation of the magnitude of the innate immune response. In 2009, Carla Rothlin was appointed as an Assistant Professor in Immunobiology at Yale School of Medicine.
Carla Rothlin co-directs a laboratory together with Sourav Ghosh, Ph.D., Associate Professor of Neurology and Pharmacology. Their research focuses on mechanisms that underlie the regulation of inflammation and the homeostatic control of immune function. Carla Rothlin is also the co-leader of the Cancer Immunology Program at the Yale Cancer Center. She is highly committed to Yale’s education mission and was appointed Director of Graduate Studies in Immunobiology in 2018. She is also one of the co-founders and lead organizers of Global Immunotalks, a weekly seminar series delivered by thought leaders in all areas of fundamental immunology. The series aims at helping to close the gap between those in the scientific community who have regular access to these kinds of talks and those who do not. Carla Rothlin’s contributions have been recognized by numerous foundations, such as the PEW Foundation and Howard Hughes Medical Institute.
ALL ARE WELCOME (No registration required)
